Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • Causal effect of plasminogen activator inhibitor type 1 on coronary heart disease 
    Song, Ci; Burgess, Stephen; Eicher, John D.; O'Donnell, Christopher J.; Johnson, Andrew D.; Huang, Jie; Sabater-Lleal, Maria; Asselbergs, Folkert W.; Tregouet, David-Alexandre; Shin, So Youn; Ding, Jingzhong; Baumert, Jens; Oudot-Mellakh, Tiphaine; Folkersen, Lasse; Smith, Nicholas L.; Williams, Scott M; Ikram, Mohammad Arfan; Kleber, Marcus E.; Becker, Diane M.; Truong, Vinh; Mychaleckyj, Josyf C.; Tang, Weihong; Yang, Qiong; Sennblad, Bengt; Moore, Jason H; Williams, Frances M.K.; Dehghan, Abbas; Silbernagel, Günther; Schrijvers, Elisabeth M.C.; Smith, Shelly; Karakas, Mahir; Tofler, Geoffrey H.; Silveira, Angela; Navis, Gerjan J.; Lohman, Kurt; Chen, Ming Huei; Peters, Annette; Goel, Anuj; Hopewell, Jemma C.; Chambers, John C.; Saleheen, Danish; Lundmark, Per; Psaty, Bruce M.; Strawbridge, Rona J.; Boehm, Bernhard O.; Onland-Moret, N. Charlotte; Uiterwaal, Cuno S.P.M.; Grobbee, Diederick E.; Bots, Michiel L.; van der Schouw, Yvonne T.; CHARGE Consortium Hemostatic Factor Working Group; ICBP Consortium; CHARGE Consortium Subclinical Working Group (Wiley-Blackwell, 2017-06-01)
    Background--Plasminogen activator inhibitor type 1 (PAI-1) plays an essential role in the fibrinolysis system and thrombosis. Population studies have reported that blood PAI-1 levels are associated with increased risk of ...
  • Association between age at menarche and cardiovascular disease: A systematic review on risk and potential mechanisms 
    Luijken, Janneke; van der Schouw, Yvonne T.; Mensink, Daniëlle; Onland-Moret, N. Charlotte (Elsevier Ireland Ltd, 2017-10-01)
    Age at menarche (AAM) has been reported to be associated with the risk of cardiovascular disease (CVD), but the shape of and the mechanisms behind this association remain unclear. We reviewed the data on the association ...
  • Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity 
    Hendricks, Audrey E.; Bochukova, Elena G.; Marenne, Gaëlle; Keogh, Julia M.; Atanassova, Neli; Bounds, Rebecca; Wheeler, Eleanor; Mistry, Vanisha; Henning, Elana; Körner, Antje; Muddyman, Dawn; McCarthy, Shane; Hinney, Anke; Hebebrand, Johannes; Scott, Robert A.; Langenberg, Claudia; Wareham, Nick J.; Surendran, Praveen; Howson, Joanna M M; Butterworth, Adam S.; Danesh, John; Nordestgaard, Børge G.; Nielsen, Sune F.; Afzal, Shoaib; Papadia, Sofia; Ashford, Sofie; Garg, Sumedha; Millhauser, Glenn L.; Palomino, Rafael I.; Kwasniewska, Alexandra; Tachmazidou, Ioanna; O'Rahilly, Stephen; Zeggini, Eleftheria; Barroso, Inês; Farooqi, I. Sadaf; Benzeval, Michaela; Burton, Jonathan; Buck, Nicholas; Jäckle, Annette; Kumari, Meena; Laurie, Heather; Lynn, Peter; Pudney, Stephen; Rabe, Birgitta; Wolke, Dieter; Overvad, Kim; Tjønneland, Anne; Clavel-Chapelon, Francoise; Kaaks, Rudolf; Boeing, Heiner; Trichopoulou, Antonia; Ferrari, Pietro; Palli, Domenico; Krogha, Vittorio; Panico, Salvatore; Tuminoa, Rosario; Matullo, Giuseppe; Boer, Jolanda Ma; Van Der Schouw, Yvonne; Weiderpass, Elisabete; Quiros, J. Ramon; Sánchez, María José; Navarro, Carmen; Moreno-Iribas, Conchi; Arriola, Larraitz; Melander, Olle; Wennberg, Patrik; Key, Timothy J.; Riboli, Elio; Al-Turki, Saeed; Anderson, Carl A; Anney, Richard; Antony, Dinu; Soler Artigas, María; Ayub, Muhammad; Bala, Senduran; Barrett, Jeffrey C; Beales, Phil; Bentham, Jamie; Bhattacharyaa, Shoumo; Birney, Ewan; Blackwooda, Douglas; Bobrow, Martin; Bolton, Patrick F.; Boustred, Chris; Breen, Gerome; Calissanoa, Mattia; Carss, Keren; Charlton, Ruth; Chatterjee, Krishna; Chen, Lu; Ciampia, Antonio; Cirak, Sebahattin; Clapham, Peter; Clement, Gail; Coates, Guy; Coccaa, Massimiliano; Collier, David A; Cosgrove, Catherine; Coxa, Tony; Craddock, Nick; Crooks, Lucy; Curran, Sarah; Curtis, David; Daly, Allan; Danecek, Petr; Day, Ian N M; Day-Williams, Aaron G; Dominiczak, Anna; Down, Thomas; Du, Yuanping; Dunham, Ian; Durbin, Richard; Edkins, Sarah; Ekong, Rosemary; Ellis, Peter; Evansa, David M.; FitzPatrick, David R.; Flicek, Paul; Floyd, James S.; Foley, A. Reghan; Franklin, Christopher S.; Futema, Marta; Gallagher, Louise; Gaunt, Tom R.; Geihs, Matthias; Geschwind, Daniel H.; Greenwood, Celia M.T.; Griffin, Heather; Grozeva, Detelina; Guo, Xiaosen; Guo, Xueqin; Gurling, Hugh; Hart, Deborah J.; Holmans, Peter A; Howie, Bryan; Huang, Jie; Huang, Liren; Hubbard, Tim; Humphries, Steve E.; Hurles, Matthew E.; Hysi, Pirro G.; Iotchkova, Valentina; Jackson, David K.; Jamshidi, Yalda; Joyce, Chris; Karczewski, Konrad J.; Kaye, Jane; Keane, Thomas; Kemp, John P.; Kennedy, Karen; Kent, Alastair; Khawaja, Farrah; Van Kogelenberg, Margriet; Kolb-Kokocinski, Anja; Lachance, Genevieve; Langford, Cordelia; Lawson, Daniel; Lee, Irene; Lek, Monkol; Li, Rui; Li, Yingrui; Liang, Jieqin; Lin, Hong; Liu, Ryan; Lönnqvist, Jouko; Lopes, Luis R.; Lopes, Margarida; MacArthur, Daniel G.; Mangino, Massimo; Marchini, Jonathan; Maslen, John; Mathieson, Iain; McGuffin, Peter; McIntosh, Andrew M.; McKechanie, Andrew G.; McQuillin, Andrew; Memari, Yasin; Metrustry, Sarah; Migone, Nicola; Min, Josine L.; Mitchison, Hannah M; Moayyeri, Alireza; Morris, Andrew D.; Morris, James; Muntoni, Francesco; Northstone, Kate; O'Donovan, Michael C.; Onoufriadis, Alexandros; Oualkacha, Karim; Owen, Michael J; Palotie, Aarno; Panoutsopoulou, Kalliope; Parker, Victoria; Parr, Jeremy R.; Paternoster, Lavinia; Paunio, Tiina; Payne, Felicity; Payne, Stewart J.; Perry, John R. B.; Pietilainen, Olli; Plagnol, Vincent; Pollitt, Rebecca C.; Porteous, David J.; Povey, Sue; Quail, Michael A.; Quaye, Lydia; Raymond, F. Lucy; Rehnström, Karola; Richards, J Brent; Ridout, Cheryl K.; Ring, Susan M.; Ritchie, Graham R.S.; Roberts, Nicola; Robinson, Rachel L.; Savage, David B.; Scambler, Peter; Schiffels, Stephan; Schmidts, Miriam; Schoenmakers, Nadia; Scott, Richard H.; Semple, Robert K.; Serra, Eva; Sharp, Sally I.; Shaw, Adam; Shihab, Hashem A.; Shin, So Youn; Skuse, David; Small, Kerrin S; Smee, Carol; Smith, Blair H.; Davey Smith, George; Soranzo, Nicole; Southam, Lorraine; Spasic-Boskovic, Olivera; Spector, Timothy D; St Clair, David; St Pourcain, Beate; Stalker, Jim; Stevens, Elizabeth; Sun, Jianping; Surdulescu, Gabriela L; Suvisaari, Jaana; Syrris, Petros; Taylor, Rohan; Tian, Jing; Timpson, Nicholas J.; Tobin, Martin D; Valdes, Ana M.; Vandersteen, Anthony M.; Vijayarangakannan, Parthiban; Visscher, Peter M.; Wain, Louise V.; Walter, Klaudia; Walters, James T.R.; Wang, Guangbiao; Wang, Jun; Wang, Nai-Yu; Ward, Kirsten; Whyte, Tamieka; Williams, Hywel J.; Williamson, Kathleen A.; Wilson, Crispian; Wilson, Scott G.; Wong, Kim; Xu, Changjiang; Yang, Jian; Zhang, Feng; Zhang, Pingbo; Zheng, Hou Feng (Nature Publishing Group, 2017-12-01)
    Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants ...
  • Fluidity of the dietary fatty acid profile and risk of coronary heart disease and ischemic stroke: Results from the EPIC-Netherlands cohort study 
    Sluijs, I; Praagman, J; Boer, J M A; Verschuren, W M M; van der Schouw, Y T (Elsevier, 2017-09)
    BACKGROUND AND AIMS: The fluidity of dietary fatty acids consumed has been suggested to inversely affect coronary heart disease (CHD) risk. Lipophilic index (LI) represents overall fluidity of the dietary fatty acid profile. ...
  • Does a better adherence to dietary guidelines reduce mortality risk and environmental impact in the Dutch sub-cohort of the European Prospective Investigation into Cancer and Nutrition? 
    Biesbroek, Sander; Verschuren, W M Monique; Boer, Jolanda M. A.; van de Kamp, Mirjam E; van der Schouw, Yvonne T; Geelen, Anouk; Looman, Moniek; Temme, Elisabeth H M (Cambridge University Press, 2017-07)
    Guidelines for a healthy diet aim to decrease the risk of chronic diseases. It is unclear as to what extent a healthy diet is also an environmentally friendly diet. In the Dutch sub-cohort of the European Prospective ...
  • Discovery and replication of SNP-SNP interactions for quantitative lipid traits in over 60,000 individuals 
    Holzinger, Emily R.; Verma, Shefali S.; Moore, Carrie B.; Hall, Molly; De, Rishika; Gilbert-Diamond, Diane; Lanktree, Matthew B.; Pankratz, Nathan; Amuzu, Antoinette; Burt, Amber; Dale, Caroline; Dudek, Scott; Furlong, Clement E.; Gaunt, Tom R.; Kim, Daniel Seung; Riess, Helene; Sivapalaratnam, Suthesh; Tragante, Vinicius; Van Iperen, Erik P.A.; Brautbar, Ariel; Carrell, David S.; Crosslin, David R.; Jarvik, Gail P.; Kuivaniemi, Helena; Kullo, Iftikhar J.; Larson, Eric B.; Rasmussen-Torvik, Laura J.; Tromp, Gerard; Baumert, Jens; Cruickshanks, Karen J.; Farrall, Martin; Hingorani, Aroon D.; Hovingh, G. K.; Kleber, Marcus E.; Klein, Barbara E.; Klein, Ronald; Koenig, Wolfgang; Lange, Leslie A.; MOrz, Winfried; North, Kari E.; Charlotte Onland-Moret, N.; Reiner, Alex P.; Talmud, Philippa J.; Van Der Schouw, Yvonne T.; Wilson, James G.; Kivimaki, Mika; Kumari, Meena; Moore, Jason H.; Drenos, Fotios; Asselbergs, Folkert W.; Keating, Brendan J.; Ritchie, Marylyn D. (BioMed Central, 2017-07-24)
    Background: The genetic etiology of human lipid quantitative traits is not fully elucidated, and interactions between variants may play a role. We performed a gene-centric interaction study for four different lipid traits: ...
  • Is brain-responsive neurostimulation in eloquent cortex without symptoms? 
    van Blooijs, Dorien; Huiskamp, Geertjan J M; Leijten, Frans S S (Wiley-Blackwell, 2017-08)
  • Immunogenicity of the 13-Valent Pneumococcal Conjugate Vaccine in Older Adults With and Without Comorbidities in the Community-Acquired Pneumonia Immunization Trial in Adults (CAPiTA) 
    van Deursen, Anna M. M.; van Houten, Marlies A; Webber, Chris; Patton, Michael; Scott, Daniel A.; Patterson, Scott; Sidhu, Mohinder; Drews, Wayne; Gruber, William C.; Emini, Emilio A.; Grobbee, Diederick E.; Bonten, Marc J. M.; Sanders, Elisabeth A. M. (Oxford University Press, 2017-09-01)
    Background. In the randomized controlled Community-Acquired Pneumonia Immunization Trial in Adults (CAPiTA), the efficacy of the 13-valent pneumococcal conjugate vaccine (PCV13) against first episodes of vaccine-type ...
  • Cytokeratin 19 expression in early oral squamous cell carcinoma and their metastasis: Inadequate biomarker for one-step nucleic acid amplification implementation in sentinel lymph node biopsy procedure 
    Noorlag, Rob; van Es, Robert J J; de Bree, Remco; Willems, Stefan M (John Wiley & Sons Inc., 2017-09)
    BACKGROUND: Intraoperative analysis of lymph nodes during a sentinel lymph node biopsy (SLNB) procedure could result in one-step surgery for early oral squamous cell carcinoma (OSCC) with an occult nodal metastasis. One-step ...
  • Low skeletal muscle mass is a predictive factor for chemotherapy dose-limiting toxicity in patients with locally advanced head and neck cancer 
    Wendrich, Anne W; Swartz, Justin E; Bril, Sandra I; Wegner, Inge; de Graeff, Alexander; Smid, Ernst J; de Bree, Remco; Pothen, Ajit J (Elsevier Limited, 2017-08)
    Objectives Low skeletal muscle mass (SMM) or sarcopenia is emerging as an adverse prognostic factor for chemotherapy dose-limiting toxicity (CLDT) and survival in cancer patients. Our aim was to determine the impact of low ...
  • Stereotactic radiosurgery versus whole-brain radiotherapy after intracranial metastasis resection: A systematic review and meta-analysis 
    Lamba, Nayan; Muskens, Ivo S; DiRisio, Aislyn C; Meijer, Louise; Briceno, Vanessa; Edrees, Heba; Aslam, Bilal; Minhas, Sadia; Verhoeff, Joost J.C.; Kleynen, Catharina E.; Smith, Timothy R; Mekary, Rania A; Broekman, Marike L. (BioMed Central, 2017-06-24)
    Background: In patients with one to three brain metastases who undergo resection, options for post-operative treatments include whole-brain radiotherapy (WBRT) or stereotactic radiosurgery (SRS) of the resection cavity. ...
  • What determines treatment satisfaction of patients with type 2 diabetes on insulin therapy?: An observational study in eight European countries 
    Boels, Anne Meike; Vos, Rimke C; Hermans, Tom G T; Zuithoff, Nicolaas P A; Müller, Nicolle; Khunti, Kamlesh; Rutten, Guy E H M; GUIDANCE study group (BMJ Publishing Group, 2017-07-01)
    OBJECTIVE: Patients with type 2 diabetes (T2DM) on insulin therapy are less satisfied with their diabetes treatment than those on oral hypoglycaemic therapies or lifestyle advice only. Determinants of satisfaction in ...
  • Validity and reliability of a Malay version of the brief illness perception questionnaire for patients with type 2 diabetes mellitus 
    Chew, Boon-How; Vos, Rimke C; Heijmans, Monique; Shariff Ghazali, Sazlina; Fernandez, Aaron; Rutten, Guy E H M (BioMed Central, 2017-08-03)
    Background: Illness perceptions involve the personal beliefs that patients have about their illness and may influence health behaviours considerably. Since an instrument to measure these perceptions for Malay population ...
  • Targeted next-generation sequencing of commonly mutated genes in esophageal adenocarcinoma patients with long-term survival 
    Visser, E; Franken, Ingrid A; Brosens, L A A; de Leng, W W J; Strengman, E; Offerhaus, J A; Ruurda, J P; van Hillegersberg, R (Wiley-Blackwell, 2017-09-01)
    Survival of patients with esophageal adenocarcinoma remains poor and individual differences in prognosis remain unexplained. This study investigated whether gene mutations can explain why patients with high-risk (pT3-4, ...
  • The effect of volumetric breast density on the risk of screen-detected and interval breast cancers: A cohort study 
    Wanders, Johanna O.P.; Holland, Katharina; Karssemeijer, Nico; Peeters, Petra H.M.; Veldhuis, Wouter B.; Mann, Ritse M.; van Gils, Carla H. (BioMed Central Ltd., 2017-06-05)
    Background: In the light of the breast density legislation in the USA, it is important to know a woman's breast cancer risk, but particularly her risk of a tumor that is not detected through mammographic screening (interval ...
  • Mammographic density and ageing: A collaborative pooled analysis of cross-sectional data from 22 countries worldwide 
    Burton, Anya; Maskarinec, Gertraud; Perez-Gomez, Beatriz; Vachon, Celine; Miao, Hui; Lajous, Martín; López-Ridaura, Ruy; Rice, Megan; Pereira, Ana; Garmendia, Maria Luisa; Tamimi, Rulla M; Bertrand, Kimberly A; Kwong, Ava; Ursin, Giske; Lee, Eunjung; Qureshi, Samera A; Ma, Huiyan; Vinnicombe, Sarah; Moss, Sue; Allen, Steve; Ndumia, Rose; Vinayak, Sudhir; Teo, Soo Hwang; Mariapun, Shivaani; Fadzli, Farhana; Peplonska, Beata; Bukowska, Agnieszka; Nagata, Chisato; Stone, Jennifer; Hopper, John L.; Giles, Graham G.; Ozmen, Vahit; Aribal, Mustafa Erkin; Schüz, Joachim; Van Gils, Carla H; Wanders, Johanna Olga Pauline; Sirous, Reza; Sirous, Mehri; Hipwell, John H; Kim, Jisun; Lee, Jong Won; Dickens, Caroline; Hartman, Mikael; Chia, Kee Seng; Scott, Christopher; Chiarelli, Anna M; Linton, Linda; Pollan, Marina; Flugelman, Anath Arzee; Salem, Dorria; Kamal, Rasha; Boyd, Norman F; Dos-Santos-Silva, Isabel; McCormack, Valerie (Public Library of Science, 2017-06)
    BACKGROUND: Mammographic density (MD) is one of the strongest breast cancer risk factors. Its age-related characteristics have been studied in women in western countries, but whether these associations apply to women ...
  • Physical ExeRcise Following Esophageal Cancer Treatment (PERFECT) study: design of a randomized controlled trial 
    van Vulpen, Jonna K; Siersema, Peter D; van Hillegersberg, Richard; Nieuwenhuijzen, Grard A P; Kouwenhoven, Ewout A; Groenendijk, Richard P R; van der Peet, Donald L; Hazebroek, Eric J; Rosman, Camiel; Schippers, Carlo C G; Steenhagen, Elles; Peeters, Petra H M; May, Anne M (BioMed Central, 2017-08-18)
    Background: Following esophagectomy, esophageal cancer patients experience a clinically relevant deterioration of health-related quality of life, both on the short- and long-term. With the currently growing number of ...
  • The prognostic value of lymph node yield in the earliest stage of colorectal cancer: a multicenter cohort study 
    Backes, Yara; Elias, Sjoerd G; Bhoelan, Bibie S; Groen, John N; van Bergeijk, Jeroen D; Seerden, Tom C J; Pullens, Hendrikus J M; Spanier, Bernhard W M; Geesing, Joost M J; Kessels, Koen; Kerkhof, Marjon; Siersema, Peter D; De Vos Tot Nederveen Cappel, Wouter H.; van Lelyveld, Niels; Wolfhagen, Frank H J; Ter Borg, Frank; Offerhaus, G Johan A; Lacle, Miangela M; Moons, Leon M G; Dutch T1 CRC Working Group (BioMed Central Ltd., 2017-07-14)
    BACKGROUND: In patients with stage II colorectal cancer (CRC) the number of surgically retrieved lymph nodes (LNs) is associated with prognosis, resulting in a minimum of 10-12 retrieved LNs being recommended for this ...
  • Targeted outreach hepatitis B vaccination program in high-risk adults: The fundamental challenge of the last mile 
    Mangen, M. J.J.; Stibbe, H; Urbanus, A.; Siedenburg, E C; Waldhober, Q; de Wit, G. A.; Steenbergen, Eric J; the National Working Group of hepatitis B behavioural risk-groups vaccination program (Elsevier, 2017-05-31)
    Background The aim of this study was to evaluate the cost-effectiveness of the on-going decentralised targeted hepatitis B vaccination program for behavioural high-risk groups operated by regional public health services ...
  • Improving cancer therapy through unraveling drug resistance 
    Brunen, Diede (Utrecht University, 2017-10-12)
    The discovery that the growth and/or survival of cancer cells is dependent on certain oncogenic drivers — also described as ‘oncogene addiction’ — provided a rationale for the development of targeted agents that specifically ...