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UMC Repository: Recent submissions

  • Cost-effectiveness analysis of lifestyle intervention in obese infertile women 
    Van Oers, Anne M.; Mutsaerts, Meike A Q; Burggraaff, Jan M.; Kuchenbecker, Walter K H; Perquin, Denise A M; Koks, Carolien A M; van Golde, R.; Kaaijk, Eugenie M; Schierbeek, Jaap M.; Klijn, Nicole F.; Van Kasteren, Yvonne M.; Land, Jolande A; Mol, B. W J; Hoek, A.; Groen, H.; Oosterhuis, G. J.E.; Broekmans, F. J.; Vogel, Niels E A; Lambalk, Cornelis B.; Verberg, Marieke F G; Mercelina, Patricia E A M; van der Veen, F; Nap, Annemiek W.; Gondrie, Ed T C M; Mulder, Robert J A B; Bruin, Jacob P; behalf of the LIFEstyle study group (Oxford University Press, 2017-07-01)
    STUDY QUESTION What is the cost-effectiveness of lifestyle intervention preceding infertility treatment in obese infertile women? SUMMARY ANSWER Lifestyle intervention preceding infertility treatment as compared to prompt ...
  • Pre-diagnostic copper and zinc biomarkers and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort 
    Stepien, Magdalena; Jenab, Mazda; Freisling, Heinz; Becker, Niels-Peter; Czuban, Magdalena; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Boutron-Ruault, Marie Christine; Mancini, Francesca Romana; Savoye, Isabelle; Katzke, Verena; Kühn, Tilman; Boeing, Heiner; Iqbal, Khalid; Trichopoulou, Antonia; Bamia, Christina; Orfanos, Philippos; Palli, Domenico; Sieri, Sabina; Tumino, Rosario; Naccarati, Alessio; Panico, Salvatore; Bueno-de-Mesquita, H. B.; Peeters, Petra H.; Weiderpass, Elisabete; Merino, Susana; Jakszyn, Paula; Sanchez, Maria-Jose; Dorronsoro, Miren; Huerta, José María; Barricarte, Aurelio; Boden, Stina; van Guelpen, Behany; Wareham, Nick; Khaw, Kay Tee; Bradbury, Kathryn E.; Cross, Amanda J.; Schomburg, Lutz; Hughes, David J. (Oxford University Press, 2017-07-01)
    Adequate intake of copper and zinc, two essential micronutrients, are important for antioxidant functions. Their imbalance may have implications for development of diseases like colorectal cancer (CRC), where oxidative ...
  • The patient perspective on remote monitoring of patients with an implantable cardioverter defibrillator: Narrative review and future directions 
    Timmermans, Ivy; Meine, Mathias; Zitron, Edgar; Widdershoven, Jos; Kimman, Geert P.; Prevot, Sébastien; Rauwolf, Thomas; Anselme, Frédéric; Szendey, Istvan; Romero Roldán, Javier; Mabo, Philippe; Schaer, Beat; Denollet, Johan; Versteeg, Henneke (Wiley-Blackwell, 2017-07-01)
    Background: Studies have shown that remote patient monitoring (RPM) of implantable cardioverter defibrillators (ICDs) is at least comparable to in-clinic follow-up with regard to clinical outcomes and might be cost-effective, ...
  • Yield of angiographic examinations in isolated intraventricular hemorrhage: A case series and systematic review of the literature 
    Hilkens, Nina A.; van Asch, Charlotte J.J.; Rinkel, Gabriel J.E.; Klijn, Catharina J.M. (SAGE Publications Inc., 2016-12-01)
    Background: It is unknown which patients with non-traumatic isolated intraventricular hemorrhage should undergo angiographic imaging to detect an underlying macrovascular cause and which modality has the highest yield. We ...
  • Epigenome-wide association of PTSD from heterogeneous cohorts with a common multi-site analysis pipeline 
    Ratanatharathorn, Andrew; Boks, Marco P.; Maihofer, Adam X.; Aiello, Allison E.; Amstadter, Ananda B.; Ashley-Koch, Allison E.; Baker, Dewleen G.; Beckham, Jean C.; Bromet, Evelyn; Dennis, Michelle; Garrett, Melanie E.; Geuze, Elbert; Guffanti, Guia; Hauser, Michael A.; Kilaru, Varun; Kimbrel, Nathan A.; Koenen, Karestan C.; Kuan, Pei Fen; Logue, Mark W.; Luft, Benjamin J.; Miller, Mark W.; Mitchell, Colter; Nugent, Nicole R.; Ressler, Kerry J; Rutten, Bart P. F.; Stein, Murray B.; Vermetten, Eric; Vinkers, Christiaan H.; Youssef, Nagy A.; Uddin, Monica; Nievergelt, Caroline M.; Smith, Alicia K; VA Mid-Atlantic MIRECC Workgroup; PGC PTSD Epigenetics Workgroup (Wiley-Liss Inc., 2017-09)
    Compelling evidence suggests that epigenetic mechanisms such as DNA methylation play a role in stress regulation and in the etiologic basis of stress related disorders such as Post traumatic Stress Disorder (PTSD). Here ...
  • Severe fat accumulation in multiple organs in pediatric autopsies: An uncommon but significant finding 
    Bleeker, Jeannette C.; Visser, Gepke; Wijburg, Frits A.; Ferdinandusse, Sacha; Rwaterham, Hans; Nikkels, Peter G.J. (SAGE Publications Inc., 2017-07-21)
    Background: The observation of fat accumulation in different organs at pediatric autopsy may help determine the cause of death. However, a comprehensive study on fat accumulation and related etiologies is still lacking. ...
  • The initial time-course of headache in patients with spontaneous subarachnoid hemorrhage 
    Čomić, Hata; Rinkel, Gabriel J.E.; Vergouwen, Mervyn D.I. (Elsevier, 2017-08-15)
    Background If acute severe headache disappears early after its onset, the question arises whether subarachnoid hemorrhage (SAH) should still be ruled out. We studied the initial time-course and minimal duration of headache ...
  • PHASES and the natural history of unruptured aneurysms: Science or pseudoscience? 
    Rinkel, G. J.E.; Algra, A.; Greving, J. P.; Vergouwen, M.D.I.; Etminan, N. (BMJ Publishing Group, 2017-06-01)
  • Increased rates of complications in singleton pregnancies of women previously diagnosed with polycystic ovary syndrome predominantly in the hyperandrogenic phenotype 
    de Wilde, Marlieke A.; Lamain-de Ruiter, Marije; Veltman-Verhulst, Susanne M.; Kwee, Anneke; Laven, Joop S.; Lambalk, Cornelis B.; Eijkemans, Marinus J.C.; Franx, Arie; Fauser, Bart C.J.M.; Koster, Maria P.H. (Elsevier, 2017-08-01)
    Objective To study the presence of several maternal and neonatal complications in a cohort of women with hyperandrogenic as well as normoandrogenic polycystic ovary syndrome (PCOS) and women with PCOS who received different ...
  • Baculoviral delivery of CRISPR/Cas9 facilitates efficient genome editing in human cells 
    Hindriksen, Sanne; Bramer, Arne J; Truong, My Anh; Vromans, Martijn J M; Post, Jasmin B; Verlaan-Klink, Ingrid; Snippert, Hugo J; Lens, Susanne M A; Hadders, Michael A (Public Library of Science, 2017)
    The CRISPR/Cas9 system is a highly effective tool for genome editing. Key to robust genome editing is the efficient delivery of the CRISPR/Cas9 machinery. Viral delivery systems are efficient vehicles for the transduction ...
  • A high-quality human reference panel reveals the complexity and distribution of genomic structural variants 
    Hehir-Kwa, Jayne Y.; Marschall, Tobias; Kloosterman, Wigard P.; Francioli, Laurent C.; Baaijens, Jasmijn A.; Dijkstra, Louis J.; Abdellaoui, Abdel; Koval, Vyacheslav; Thung, Djie Tjwan; Wardenaar, René; Renkens, Ivo; Coe, Bradley P.; Deelen, Patrick; De Ligt, Joep; Lameijer, Eric Wubbo; Van Dijk, Freerk; Hormozdiari, Fereydoun; Uitterlinden, André G.; Van Duijn, Cornelia M.; Eichler, Evan E.; De Bakker, Paul I.W.; Swertz, Morris A.; Wijmenga, Cisca; Van Ommen, Gert Jan B; Slagboom, P. Eline; Boomsma, Dorret I.; Schönhuth, Alexander; Ye, Kai; Guryev, Victor; Bovenberg, Jasper A.; De Craen, Anton J M; Beekman, Marian; Hofman, Albert; Willemsen, Gonneke; Wolffenbuttel, Bruce; Platteel, Mathieu; Du, Yuanping; Chen, Ruoyan; Cao, Hongzhi; Cao, Rui; Sun, Yushen; Cao, Jeremy Sujie; Neerincx, Pieter B T; Dijkstra, Martijn; Byelas, George; Kanterakis, Alexandros; Bot, Jan; Vermaat, Martijn; Laros, Jeroen F.; den Dunnen, Johan T.; De Knijff, Peter; Karssen, Lennart C.; Van Leeuwen, Elisa M.; Amin, Najaf; Rivadeneira, Fernando; Estrada, Karol; Hottenga, Jouke-Jan; Kattenberg, V. Mathijs; Van Enckevort, David; Mei, Hailiang; Santcroos, Mark; Van Schaik, Barbera D C; Handsaker, Robert E.; McCarroll, Steven A.; Ko, Arthur; Sudmant, Peter; Nijman, Isaac J. (Nature Publishing Group, 2016-10-06)
    Structural variation (SV) represents a major source of differences between individual human genomes and has been linked to disease phenotypes. However, the majority of studies provide neither a global view of the full ...
  • A computationally simple central monitoring procedure, effectively applied to empirical trial data with known fraud 
    van den Bor, Rutger M; Vaessen, Petrus W J; Oosterman, Bas J; Zuithoff, Nicolaas P A; Grobbee, Diederick E; Roes, Kit C B (Elsevier, 2017-07)
    OBJECTIVES: Central monitoring of multicenter clinical trials becomes an ever more feasible quality assurance tool, in particular for the detection of data fabrication. More widespread application, across both industry ...
  • Predicting clinical benefit from everolimus in patients with advanced solid tumors, the CPCT-03 study 
    Weeber, Fleur; Cirkel, Geert A.; Hoogstraat, Marlous; Bins, Sander; Gadellaa-van Hooijdonk, Christa G.M.; Ooft, Salo; van Werkhoven, Erik; Willems, Stefan M.; van Stralen, Marijn; Veldhuis, Wouter B.; Besselink, Nicolle J M; Horlings, Hugo M; Steeghs, Neeltje; de Jonge, Maja J.; Langenberg, Marlies H.G.; Wessels, Lodewyk F A; Cuppen, Edwin P.J.G.; Schellens, J.H.; Sleijfer, Stefan; Lolkema, Martijn P.; Voest, Emile E. (Impact Journals, 2017-08-15)
    Background: In this study, our aim was to identify molecular aberrations predictive for response to everolimus, an mTOR inhibitor, regardless of tumor type. Methods: To generate hypotheses about potential markers for ...
  • Eigentumors for prediction of treatment failure in patients with early-stage breast cancer using dynamic contrast-enhanced MRI: a feasibility study 
    Chan, HM; van der Velden, Bas H M; Loo, Claudette E.; Gilhuijs, Kenneth G A (IOP Publishing Ltd., 2017)
    We present a radiomics model to discriminate between patients at low risk and those at high risk of treatment failure at long-term follow-up based on eigentumors: principal components computed from volumes encompassing ...
  • Moving toward endotypes in atopic dermatitis: Identification of patient clusters based on serum biomarker analysis 
    Thijs, Judith L.; Strickland, Ian; Bruijnzeel-Koomen, Carla A.F.M.; Nierkens, Stefan; Giovannone, Barbara; Csomor, Eszter; Sellman, Bret R.; Mustelin, Tomas; Sleeman, Matthew A.; de Bruin-Weller, Marjolein S.; Herath, Athula; Drylewicz, Julia; May, Richard D.; Hijnen, Dirk Jan (Mosby Inc., 2017-09)
    Background: Atopic dermatitis (AD) is a complex, chronic, inflammatory skin disease with a diverse clinical presentation. However, it is unclear whether this diversity exists at a biological level. Objective: We sought to ...
  • Goblet cells contribute to ocular surface immune tolerance—implications for dry eye disease 
    Barbosa, Flavia L.; Xiao, Yangyan; Bian, Fang; Coursey, Terry G.; Ko, Byung Yi; Clevers, Hans; de Paiva, Cintia S.; Pflugfelder, Stephen C. (Multidisciplinary Digital Publishing Institute (MDPI), 2017-05-05)
    Conjunctival goblet cell (GC) loss in dry eye is associated with ocular surface inflammation. This study investigated if conjunctival GCs contribute to ocular surface immune tolerance. Antigens applied to the ocular surface, ...
  • Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease 
    Claessens, Nathalie H. P.; Kelly, Christopher J; Counsell, Serena J.; Benders, Manon J. N. L. (Wiley-Blackwell, 2017-09)
    This review integrates data on brain dysmaturation and acquired brain injury using fetal and neonatal magnetic resonance imaging (MRI), including the contribution of cardiovascular physiology to differences in brain ...
  • Relation between Kidney Length and Cardiovascular and Renal Risk in High-Risk Patients 
    van der Sande, Nicolette G C; Visseren, Frank L J; van der Graaf, Yolanda; Nathoe, Hendrik M; Jan de Borst, Gert; Leiner, Tim; Blankestijn, Peter J; SMART Study Group (Lippincott Williams & Wilkins, 2017-06)
    Background and objectives Kidney length is often measured during routine abdominal ultrasonography and may be of use to identify patients at high vascular and renal risk. We aimed to explore patient characteristics related ...
  • Immune reconstitution inflammatory syndrome associated with toxoplasmic encephalitis in hiv-infected patients: a multicenter cohort study 
    van Bilsen, Ward P H; van den Berg, Charlotte H S B; Rijnders, Bart J A; Brinkman, Kees; Mulder, Jan W.; Gelinck, Luc B S; Hoepelman, Andy I M; Wit, Ferdinand W N M; van de Beek, Diederik; Prins, Jan M. (Lippincott Williams & Wilkins, 2017-06)
    OBJECTIVES:: To investigate the incidence and risk factors of immune reconstitution inflammatory syndrome (IRIS) associated with toxoplasmic encephalitis (TE) in patients starting cART. DESIGN:: A historical multicenter ...
  • Predictors of Knowledge and Image Interpretation Skill Development in Radiology Residents 
    Ravesloot, Cécile J; van der Schaaf, Marieke F; Kruitwagen, Cas L J J; van der Gijp, Anouk; Rutgers, Dirk R; Haaring, Cees; Ten Cate, Olle; van Schaik, Jan P J (Radiological Society of North America Inc., 2017)
    Purpose To investigate knowledge and image interpretation skill development in residency by studying scores on knowledge and image questions on radiology tests, mediated by the training environment. Materials and Methods ...