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  • Cardiopulmonary Exercise Testing in Pediatrics 
    Takken, Tim; Bongers, Bart C; van Brussel, Marco; Haapala, Eero A; Hulzebos, Erik Hj (American Thoracic Society, 2017-07-01)
    Aerobic fitness is an important determinant of overall health. Higher aerobic fitness has been associated with many health benefits. Because myocardial ischemia is rare in children, indications for exercise testing differ ...
  • Obstacles and opportunities in the functional analysis of extracellular vesicle RNA - An ISEV position paper 
    Mateescu, Bogdan; Kowal, Emma J K; van Balkom, Bas W M; Bartel, Sabine; Bhattacharyya, Suvendra N.; Buzás, Edit I.; Buck, Amy H.; de Candia, Paola; Chow, Franklin W N; Das, Saumya; Driedonks, Tom A P; Fernández-Messina, Lola; Haderk, Franziska; Hill, Andrew F.; Jones, Jennifer C.; Van Keuren-Jensen, Kendall R.; Lai, Charles P.; Lässer, Cecilia; di Liegro, Italia; Lunavat, Taral R.; Lorenowicz, Magdalena J.; Maas, Sybren L N; Mäger, Imre; Mittelbrunn, Maria; Momma, Stefan; Mukherjee, Kamalika; Nawaz, Muhammed; Pegtel, D. Michiel; Pfaffl, Michael W.; Schiffelers, Raymond M.; Tahara, Hidetoshi; Théry, Clotilde; Tosar, Juan Pablo; Wauben, Marca H M; Witwer, Kenneth W.; Nolte-'t Hoen, Esther N M (John Wiley & Sons Inc., 2017)
    The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has been demonstrated in a multitude of different in vitro cell systems and in a variety of body fluids. RNA-containing EV are in the ...
  • Reply 
    Tran-Duy, An; Spaetgens, Bart; Hoes, Arno W.; de Wit, Niek J.; Stehouwer, Coen D A (W.B. Saunders, 2017-05)
    Refers to Robert H. Palmer Use of Proton Pump Inhibitors and Risks of Fundic Gland Polyps and Gastric Cancer: Systematic Review and Meta-analysis Clinical Gastroenterology and Hepatology, Volume 15, Issue 5, May 2017, Pages 790
  • Head-to-head comparison of health-state values derived by a probabilistic choice model and scores on a visual analogue scale 
    Krabbe, Paul F M; Stolk, Elly A.; Devlin, Nancy J.; Xie, Feng; Quik, Elise H.; Pickard, A. Simon (Springer-Verlag, 2017-11)
    Background: Health states were quantified based on discrete choice (DC) modeling and visual analogue scale (VAS) values using the five-level version of the EQ-5D (EQ-5D-5L). The aim of this study was to determine the extent ...
  • Hip muscle strength is decreased in middle-aged recreational male athletes with midportion Achilles tendinopathy: A cross-sectional study 
    Habets, B; Smits, H W; Backx, F J G; van Cingel, R E H; Huisstede, B M A (Elsevier, 2017-05)
    Objective Investigating differences in hip muscle strength between athletes with Achilles tendinopathy (AT) and asymptomatic controls. Design Cross-sectional case-control study. Setting Sports medical center. Participants ...
  • Genetic transmission of reading ability 
    Swagerman, Suzanne C.; Van Bergen, Elsje; Dolan, Conor; de Geus, Eco J. C.; Koenis, Marinka M.G.; Hulshoff Pol, Hilleke E.; Boomsma, Dorret I. (Academic Press Inc., 2017-09-01)
    Reading is the processing of written language. Family resemblance for reading (dis)ability might be due to transmission of a genetic liability or due to family environment, including cultural transmission from parents to ...
  • Validity and Reliability of Skill-Related Fitness Tests for Wheelchair-Using Youth With Spina Bifida 
    Bloemen, Manon A.; Takken, Tim; Backx, Frank J.; Vos, Marleen; Kruitwagen, Cas L.; de Groot, Janke F. (W.B. Saunders, 2017-06)
    OBJECTIVE: To determine content validity of the Muscle Power Sprint Test (MPST) and construct validity and reliability of the MPST, 10x5 Meter Sprint Test (10x5MST), slalom test and one stroke push test (1SPT) in ...
  • Effects of a pre-operative home-based inspiratory muscle training programme on perceived health-related quality of life in patients undergoing coronary artery bypass graft surgery 
    Valkenet, K.; Trappenburg, J. C A; Hulzebos, E. H.; van Meeteren, N. L U; Backx, F. J G (Elsevier, 2017-09)
    Objectives: Pre-operative inspiratory muscle training has been shown to decrease the incidence of postoperative pneumonia and length of hospital stay in patients undergoing coronary artery bypass graft surgery (CABG). This ...
  • Pharmacokinetics of Anidulafungin in critically ill patients in the Intensive Care Unit with suspected or proven invasive fungal infections 
    Brüggemann, R J M; Middel-Baars, V; de Lange, D W; Colbers, A; Girbes, A R J; Pickkers, P; Swart, E L (American Society for Microbiology, 2017-02-01)
    Echinocandins, such as anidulafungin, are the first-line treatment for candidemia or invasive candidiasis in critically ill patients. There are conflicting data on the pharmacokinetic properties of anidulafungin in intensive ...
  • Air filled, including "air-charged," catheters in urodynamic studies: does the evidence justify their use? 
    Abrams, Paul; Damaser, Margot S; Niblett, Philip; Rosier, Peter F W M; Toozs-Hobson, Philip; Hosker, Gordon; Kightley, Robert; Gammie, Andrew (John Wiley & Sons Inc., 2017-06)
    AIMS: Air filled catheters (AFCs) have been actively marketed for the past few years and in some geographic areas are widely used. However, as the scientific basis for introduction of this technology for pressure measurement ...
  • Effectiveness of Shockwave Treatment Combined With Eccentric Training for Patellar Tendinopathy: A Double-Blinded Randomized Study 
    Thijs, Karin M; Zwerver, Johannes; Backx, Frank J G; Steeneken, Victor; Rayer, Stephan; Groenenboom, Petra; Moen, Maarten H (Lippincott Williams & Wilkins, 2017-03)
    OBJECTIVE: To evaluate the effectiveness of a combined treatment of focused shockwave therapy (ESWT) and eccentric training compared with sham-shockwave therapy (placebo) and eccentric training in participants with patellar ...
  • Knee joint distraction compared with high tibial osteotomy: a randomized controlled trial 
    van der Woude, J. A D; Wiegant, K.; van Heerwaarden, R. J.; Spruijt, S.; van Roermund, P. M.; Custers, R. J H; Mastbergen, S. C.; Lafeber, F. P J G (Springer-Verlag, 2017-03)
    Purpose: Both, knee joint distraction as a relatively new approach and valgus-producing opening-wedge high tibial osteotomy (HTO), are knee-preserving treatments for knee osteoarthritis (OA). The efficacy of knee joint ...
  • Reproductive characteristics of women diagnosed with premature ovarian insufficiency 
    Daan, Nadine M P; Hoek, Annemieke; Corpeleijn, Eva; Eijkemans, Marinus J C; Broekmans, Frank J.; Fauser, Bart C J M; Koster, Maria P H (Elsevier, 2016-02)
    In this retrospective cohort study (n = 479), the proportion of women with premature ovarian insufficiency (POI) who conceived was assessed, the reproductive characteristics of women with POI who had previously been pregnant ...
  • Hypoxia-Targeting Fluorescent Nanobodies for Optical Molecular Imaging of Pre-Invasive Breast Cancer 
    van Brussel, Aram S A; Adams, Arthur; Oliveira, Sabrina; Dorresteijn, Bram; El Khattabi, Mohamed; Vermeulen, Jeroen F.; van der Wall, Elsken; Mali, W.P.T.M.; Derksen, Patrick W B; van Diest, Paul J.; van Bergen En Henegouwen, Paul M P (Springer New York, 2016-08)
    Purpose: The aim of this work was to develop a CAIX-specific nanobody conjugated to IRDye800CW for molecular imaging of pre-invasive breast cancer. Procedures: CAIX-specific nanobodies were selected using a modified phage ...
  • iPSC-derived Insights into Motor Neuron Disease and Inflammatory Neuropathies 
    Härschnitz, O. (Utrecht University, 2017-09-15)
    The proper function of the motor circuit is essential for normal interaction as a human being with external cues. While the motor circuit consists of a variety of cell types, one of its core components is the motor neuron ...
  • Magnetic Resonance Imaging of Stroke 
    Bouts, Mark. J. R. J.; Wu, O.; Dijkhuizen, R. M. (Elsevier, 2017-03-07)
    Magnetic resonance imaging (MRI) provides a powerful (neuro)imaging modality for the diagnosis and outcome prediction after (acute) stroke. Since MRI allows noninvasive, longitudinal, and three-dimensional assessment of ...
  • Treatment of Peritoneal Dissemination in Stomach Cancer Patients With Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Rationale and Design of the PERISCOPE Study 
    van der Kaaij, Rosa T; Braam, Hidde Jw; Boot, Henk; Los, Maartje; Cats, Annemieke; Grootscholten, Cecile; Schellens, Jan Hm; Aalbers, Arend Gj; Huitema, Alwin Dr; Knibbe, Catherijne Aj; Boerma, Djamila; Wiezer, Marinus J; van Ramshorst, Bert; van Sandick, Johanna W. (JMIR Publications Inc., 2017-07-13)
    Background: Patients with gastric cancer and peritoneal carcinomatosis have a very poor prognosis; median survival is 3 to 4 months. Palliative systemic chemotherapy is currently the only treatment available in the ...
  • Early health technology assessment of magnetic resonance-guided high intensity focused ultrasound ablation for the treatment of early-stage breast cancer 
    Knuttel, Floortje M.; Huijsse, Sèvrin E.M.; Feenstra, Talitha L.; Moonen, Chrit T.W.; van den Bosch, Maurice A.A.J.; Buskens, Erik; Greuter, Marcel J W; de Bock, Geertruida H. (BioMed Central, 2017-08-01)
    Background: Magnetic resonance-guided high intensity focused ultrasound (MR-HIFU) ablation is in development for minimally invasive treatment of breast cancer. Cost-effectiveness has not been assessed yet. An early health ...
  • De Novo Mutations in YWHAG Cause Early-Onset Epilepsy 
    Guella, Ilaria; McKenzie, Marna B.; Evans, Daniel M.; Buerki, Sarah E.; Toyota, Eric B.; Van Allen, Margot I.; Adam, Shelin; Boelman, Cyrus; Bolbocean, Corneliu; Candido, Tara; Eydoux, Patrice; Horvath, Gabriella; Huh, Linda; Nelson, Tanya N.; Sinclair, Graham; van Karnebeek, Clara D M; Vercauteren, Suzanne; Suri, Mohnish; Elmslie, Frances; Simon, Marleen E.H.; van Gassen, Koen L.I.; Héron, Delphine; Keren, Boris; Nava, Caroline; Connolly, Mary B.; Demos, Michelle; Farrer, Matthew J.; Epilepsy Genomics Study; Deciphering Developmental Disorders Study; Deciphering Developmental Disorders Study (Cell Press, 2017-08-03)
    Massively parallel sequencing has revealed many de novo mutations in the etiology of developmental and epileptic encephalopathies (EEs), highlighting their genetic heterogeneity. Additional candidate genes have been ...
  • MCM3AP in recessive Charcot-Marie-Tooth neuropathy and mild intellectual disability 
    Ylikallio, Emil; Woldegebriel, Rosa; Tumiati, Manuela; Isohanni, Pirjo; Ryan, Monique M.; Stark, Zornitza; Walsh, Maie; Sawyer, Sarah L.; Bell, Katrina M.; Oshlack, Alicia; Lockhart, Paul J.; Shcherbii, Mariia; Estrada-Cuzcano, Alejandro; Atkinson, Derek; Hartley, Taila; Tetreault, Martine; Cuppen, Inge; Van Der Pol, W. Ludo; Candayan, Ayse; Battaloglu, Esra; Parman, Yesim; Van Gassen, Koen L.I.; Van Den Boogaard, Marie José H.; Boycott, Kym M.; Kauppi, Liisa; Jordanova, Albena; Lönnqvist, Tuula; Tyynismaa, Henna (Oxford University Press, 2017-08-01)
    Defects in mRNA export from the nucleus have been linked to various neurodegenerative disorders. We report mutations in the gene MCM3AP, encoding the germinal center associated nuclear protein (GANP), in nine affected ...