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Now showing items 28901-28920 of 40729

Coding and small non-coding transcriptional landscape of tuberous sclerosis complex cortical tubers: Implications for pathophysiology and treatment

Mills, James D.; Iyer, Anand M.; Van Scheppingen, Jackelien; Bongaarts, Anika; Anink, Jasper; Janssen, Bart; Zimmer, Till S.; Spliet, Wim G.; Van Rijen, Peter C.; Jansen, Floor E.; Feucht, Martha; Hainfellner, Johannes A; Krsek, Pavel; Zamecnik, Josef; Kotulska, Katarzyna; Jozwiak, Sergiusz; Jansen, Anna; Lagae, Lieven; Curatolo, Paolo; Kwiatkowski, David J.; Jeroen Pasterkamp, R.; Senthilkumar, Ketharini; von Oerthel, Lars; Hoekman, Marco F. M.; Gorter, Jan A; Crino, Peter B; Mühlebner, Angelika; Scicluna, Brendon P; Aronica, Eleonora (Nature Publishing Group, 2017-08-14)

Tuberous Sclerosis Complex (TSC) is a rare genetic disorder that results from a mutation in the TSC1 or TSC2 genes leading to constitutive activation of the mechanistic target of rapamycin complex 1 (mTORC1). TSC is ...
Glioma-associated epilepsy: Toward mechanism-based treatment

Snijders, Tom J.; Berendsen, Sharon; Seute, Tatjana; Robe, Pierre A. (AME Publishing Company, 2017-03-01)

Epilepsy is common in glioma patients, and glioma-related epilepsy has a strong impact on patients' quality of life. Glioma-related epilepsy has a unfavorable clinical course when compared to other types of symptomatic ...
Molecular-based recursive partitioning analysis model for glioblastoma in the temozolomide era a correlative analysis based on nrg oncology RTOG 0525

Bell, Erica Hlavin; Pugh, Stephanie L.; McElroy, Joseph P.; Gilbert, Mark R.; Mehta, Minesh; Klimowicz, Alexander C.; Magliocco, Anthony; Bredel, Markus; Robe, Pierre; Grosu, Anca L.; Stupp, Roger; Curran, Walter; Becker, Aline P.; Salavaggione, Andrea L.; Barnholtz-Sloan, Jill S.; Aldape, Kenneth; Blumenthal, Deborah T.; Brown, Paul D.; Glass, Jon; Souhami, Luis; Lee, R. Jeffrey; Brachman, David; Flickinger, John; Won, Minhee; Chakravarti, Arnab (American Medical Association, 2017-06-01)

IMPORTANCE: There is a need for a more refined, molecularly based classification model for glioblastoma (GBM) in the temozolomide era. OBJECTIVE: To refine the existing clinically based recursive partitioning analysis (RPA) ...
Ethical difficulties in the innovative surgical treatment of patients with recurrent glioblastoma multiforme

Cote, David J; Balak, Naci; Brennum, Jannick; Holsgrove, Daniel T.; Kitchen, Neil; Kolenda, Herbert; Moojen, Wouter A.; Schaller, Karl; Robe, Pierre A.; Mathiesen, Tiit; Broekman, Marike L. (American Association of Neurological Surgeons, 2017-06-01)
Tumor-related neurocognitive dysfunction in patients with diffuse glioma: a systematic review of neurocognitive functioning prior to anti-tumor treatment

van Kessel, Emma; Baumfalk, Anniek E.; van Zandvoort, Martine J.E.; Robe, Pierre A.; Snijders, Tom J. (Kluwer Academic Publishers, 2017-08-01)

Deficits in neurocognitive functioning (NCF) frequently occur in glioma patients. Both treatment and the tumor itself contribute to these deficits. Data about the role of the tumor are scarce, because NCF has mostly been ...
Cost-effectiveness of laparoscopy as diagnostic tool before primary cytoreductive surgery in ovarian cancer

van de Vrie, Roelien; van Meurs, Hannah S; Rutten, Marianne J; Naaktgeboren, Christiana A.; Opmeer, Brent C.; Gaarenstroom, Katja N; van Gorp, Toon; Ter Brugge, Henk G; Hofhuis, Ward; Schreuder, Henk W R; Arts, Henriette J G; Zusterzeel, Petra L M; Pijnenborg, Johanna M A; van Haaften, Maarten; Engelen, Mirjam J A; Boss, Erik A; Vos, M Caroline; Gerestein, Kees G.; Schutter, Eltjo M J; Kenter, Gemma G; Bossuyt, Patrick M. M.; Mol, Ben Willem; Buist, Marrije R (Academic Press Inc., 2017-09-01)

Objective To evaluate the cost-effectiveness of a diagnostic laparoscopy prior to primary cytoreductive surgery to prevent futile primary cytoreductive surgery (i.e. leaving > 1 cm residual disease) in patients suspected ...
Postoperative complications and weight loss following jejunostomy tube feeding after total gastrectomy for advanced adenocarcinomas

Brenkman, Hylke J.F.; Roelen, Stéphanie V.S.; Steenhagen, Elles; Ruurda, Jelle P.; van Hillegersberg, Richard (AME Publishing Company, 2017-08-01)

Objective: Patients undergoing total gastrectomy for cancer are at risk of malnourishment. The aim of this selfcontrolled study was to examine the effect of jejunostomy tube feeding (JTF) and other factors on postoperative ...
Role of Hormonal Treatment in Prostate Cancer Patients with Nonmetastatic Disease Recurrence after Local Curative Treatment: A Systematic Review

van den Bergh, Roderick C. N.; van Casteren, Niels J.; van den Broeck, Thomas; Fordyce, Eve R.; Gietzmann, William K. M.; Stewart, Fiona; MacLennan, Steven; Dabestani, Saeed; Bellmunt, Joaquim; Bolla, Michel; Briers, Erik; Cornford, Philip; Joniau, Steven; Mason, Malcolm D.; Matveev, Vsevolod; Van Der Poel, Henk G.; van der Kwast, Theo H.; Rouvière, Olivier; Wiegel, Thomas; Lam, Thomas B; Mottet, Nicolas (Elsevier, 2016-05-01)

Context The relative benefits and harms of hormonal treatment (HT) versus no or deferred HT in patients with nonmetastatic prostate cancer (PCa) relapse after primary curative therapy are controversial. Objective To assess ...
Patients are dissatisfied with information provision: perceived information provision and quality of life in prostate cancer patients

Lamers, Romy E D; Cuypers, Maarten; Husson, Olga; de Vries, Marieke; Kil, Paul J M; Bosch, J. L. H. Ruud; van de Poll-Franse, Lonneke V. (John Wiley & Sons Inc., 2016-06)

Objective To determine the satisfaction with information received by prostate cancer survivors and associations with health-related quality of life (HRQoL) and illness perception. Methods A cross-sectional study was performed ...
Sympathomodulatory effects of sodium-glucose transporter-2 inhibitors in the kidneys and beyond

Blankestijn, Peter J.; Wanner, Christoph; Grassi, Guido (Lippincott Williams & Wilkins, 2017-10-01)
Medical students' cognitive load in volumetric image interpretation: Insights from human-computer interaction and eye movements

Stuijfzand, Bobby G.; van der Schaaf, Marieke F; Kirschner, Femke C.; Ravesloot, Cécile J.; Van Der Gijp, Anouk; Vincken, Koen L. (Elsevier Limited, 2016-09-01)

Medical image interpretation is moving from using 2D- to volumetric images, thereby changing the cognitive and perceptual processes involved. This is expected to affect medical students' experienced cognitive load, while ...
Prediction of hemorrhagic transformation after experimental ischemic stroke using MRI-based algorithms

Bouts, Mark. J. R. J.; Tiebosch, Ivo A.C.W.; Rudrapatna, Umesh S; van der Toorn, Annette; Wu, Ona; Dijkhuizen, Rick M. (SAGE Publications Inc., 2017-08-01)

Estimation of hemorrhagic transformation (HT) risk is crucial for treatment decision–making after acute ischemic stroke. We aimed to determine the accuracy of multiparametric MRI-based predictive algorithms in calculating ...
Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability

Willems, Anke P.; Gundogdu, Mehmet; Kempers, Marlies J.E.; Giltay, Jacques C; Pfundt, Rolph; Elferink, Martin; Loza, Bettina F.; Fuijkschot, Joris; Ferenbach, Andrew T.; Van Gassen, Koen L.I.; van Aalten, Daan M. F.; Lefeber, Dirk J. (American Society for Biochemistry and Molecular Biology Inc., 2017-07-28)

N-Acetylglucosamine (O-GlcNAc) transferase (OGT) regulates protein O-GlcNAcylation, an essential and dynamic post-translational modification. The O-GlcNAc modification is present on numerous nuclear and cytosolic proteins ...
Incomplete biomarker response in mucopolysaccharidosis type I after successful hematopoietic cell transplantation

Kuiper, Gé Ann; van Hasselt, Peter M.; Boelens, Jaap Jan; Wijburg, Frits A.; Langereis, Eveline J. (Academic Press Inc., 2017-09)

Background: Residual disease, primarily involving musculoskeletal tissue, is a common problem in patients with neuronopathic mucopolysaccharidosis type I (MPS I, Hurler or severe Hurler-Scheie phenotype) after a successful ...
Short-term variability of repolarization is superior to other repolarization parameters in the evaluation of diverse antiarrhythmic interventions in the chronic atrioventricular block dog

Bossu, Alexandre; Varkevisser, Rosanne; Beekman, Henriette D.M.; Houtman, Marien J C; Van Der Heyden, Marcel A.G.; Vos, Marc A. (Lippincott Williams & Wilkins, 2017-06-01)

Short-term variability (STV), to quantify beat-to-beat variability of repolarization, is a surrogate parameter that reliably identifies proarrhythmic risk in preclinical models. Examples include not only the use in the ...
Automatic detection and visualisation of MEG ripple oscillations in epilepsy

van Klink, Nicole; van Rosmalen, Frank; Nenonen, Jukka; Burnos, Sergey; Helle, Liisa; Taulu, Samu; Furlong, Paul Lawrence; Zijlmans, Maeike; Hillebrand, Arjan (Elsevier, 2017)

High frequency oscillations (HFOs, 80–500 Hz) in invasive EEG are a biomarker for the epileptic focus. Ripples (80–250 Hz) have also been identified in non-invasive MEG, yet detection is impeded by noise, their low occurrence ...
In search of the optimal platform for Post-Allogeneic SCT immunotherapy in relapsed multiple myeloma: a systematic review

Oostvogels, R; Uniken Venema, S M; de Witte, M; Raymakers, R; Kuball, J; Kröger, N.; Minnema, M C (Springer Nature, 2017-09)

Allogeneic stem cell transplantation (allo-SCT) has the potential to induce sustained remissions in patients with multiple myeloma (MM). Currently, allo-SCT is primarily performed in high-risk MM patients, most often in ...
3D bioprinting of methacrylated hyaluronic acid (MeHA) hydrogel with intrinsic osteogenicity

Poldervaart, Michelle T.; Goversen, Birgit; De Ruijter, Mylene; Abbadessa, Anna; Melchels, Ferry P.W.; Öner, F. Cumhur; Dhert, Wouter J A; Vermonden, Tina; Alblas, Jacqueline (Public Library of Science, 2017-06-01)

In bone regenerative medicine there is a need for suitable bone substitutes. Hydrogels have excellent biocompatible and biodegradable characteristics, but their visco-elastic properties limit their applicability, especially ...
Effectiveness and cost-effectiveness of nationwide campaigns for awareness and case finding of hepatitis C targeted at people who inject drugs and the general population in the Netherlands

Helsper, Charles W.; Janssen, Mart P.; van Essen, Gerrit A.; Croes, Esther A; van der Veen, Clary; de Wit, Ardine G.; de Wit, Niek J. (Elsevier, 2017-09-01)

Background Hepatitis C virus infection (HCV) is a serious, but underdiagnosed disease that can generally be treated successfully. Therefore, a nationwide HCV awareness campaign was implemented in the Netherlands targeting ...
Subgroup analyses in confirmatory clinical trials: Time to be specific about their purposes

Tanniou, Julien; Van Der Tweel, Ingeborg; Teerenstra, Steven; Roes, Kit C.B. (BioMed Central, 2016-02-18)

Background: It is well recognized that treatment effects may not be homogeneous across the study population. Subgroup analyses constitute a fundamental step in the assessment of evidence from confirmatory (Phase III) ...

Now showing items 28901-28920 of 40729