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UMC Repository: Recent submissions

  • On the origin of neutrophils 
    Koenderman, Leo; Tesselaar, Kiki; Vrisekoop, Nienke (Springer Nature, 2025-02-27)
  • HMOS 2’FL and 3FL prevent house dust mite induced proinflammatory cytokine release in vitro and decrease specific IgE production in a murine allergic asthma model 
    Zuurveld, Marit; de Kleer, Janna W.M.; Berends, Alinda J.; Kooy, Manou M.; Van Ark, Ingrid; Leusink-Muis, Thea; Kettelarij, Nienke; Folkerts, Gert; Garssen, Johan; van ’t Land, Belinda; Willemsen, Linette E.M. (Frontiers Media S. A., 2025-02-19)
    Introduction: Allergic asthma is characterized by sensitization to airborne allergens like house dust mite (HDM). Human milk oligosaccharides (HMOS) are linked to improved immune maturation and potentially alleviate allergy ...
  • From digital harm to recovery: a multidisciplinary framework for First Aid after Online Sexual Abuse 
    Knipschild, Rik; Covers, Milou; Bicanic, Iva A.E. (Co-Action Publishing, 2025-12-01)
    Online sexual abuse in adolescence encompasses various forms of digital exploitation, including grooming, sexting, sextortion, and image-based sexual abuse. Current research indicates that a significant proportion of minors ...
  • Genetic Alterations, Therapy Response, and Survival Among Patients With Triple-Negative Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial 
    Richters, Lisa; Gluz, Oleg; Weber-Lassalle, Nana; Christgen, Matthias; Haverkamp, Heinz; Kuemmel, Sherko; Kayali, Mohamad; Kates, Ronald E.; Grischke, Eva Maria; Altmüller, Janine; Forstbauer, Helmut; Thiele, Holger; Braun, Michael; Warm, Mathias; Ossowski, Anna; Wuerstlein, Rachel; Ernst, Corinna; Graeser, Monika; Linn, Sabine C.; Nitz, Ulrike; Hauke, Jan; Kreipe, Hans Heinrich; Schmutzler, Rita K.; Hahnen, Eric; Harbeck, Nadia (American Medical Association, 2025-02-03)
    Importance: Subgroup definitions for possible deescalation of neoadjuvant cancer treatment are urgently needed in clinical practice. Objective: To investigate the effect of BRCA1 and/or BRCA2 tumor pathogenic variants ...
  • European general practitioners' attitudes towards person-centred care and factors that influence its implementation in everyday practice: The protocol of the cross-sectional PACE GP/FP study in 24 European countries 
    Petriček, Goranka; Klemenc-Ketiš, Zalika; Ožvačić Adžić, Zlata; Cerovečki, Venija; Willems, Sara; Tsimtsiou, Zoi; Zelko, Erika; Collins, Claire; Hoffmann, Kathryn; Eide, Torunn Bjerve; Ares Blanco, Sara; Frese, Thomas; Lingner, Heidrun; Assenova, Radost; Torzsa, Péter; Seifert, Bohumil; Ungan, Mehmet; Bayen, Sabine; Windak, Adam; Azeredo, Joana; Stavrikj, Katarina; Kreitmayer, Sanda; Kostić, Milena; Busneag, Iliana Carmen; Koskela, Tuomas; Serafini, Alice; Butterworth, Joanne; Zwart, Dorien Louise Maria; González-Lama, Jesús; Vuletić, Gorka; Van Poel, Esther; Tušek Bunc, Ksenija; Tuz, Canan; Mevsim, Vildan; Seifert, Martin; Dahli, Mina; Hrabač, Pero; Hanževački, Miroslav; Rakić Matić, Jelena; Tomičić, Marion; Rađa, Marko; Heleno, Bruno; Studzinski, Krzysztof; Becze, Ádám; Megallón-Botaya, Rosa; Rogers, Heather Lynn; Brütting, Christine; Kafadar, Didem; Lerma Irureta, David; Fornacciari, Davide; Nessler, Katarzyna; Soleski, Kiril; Méndez-López, Fátima; Çöme, Oğulcan; Ahmad, Abeer; Petek, Davorina (Informa Healthcare, 2025-12-01)
    BACKGROUND: Person-centred care (PCC) is a fundamental principle in general practice, emphasising practices tailored to individual patient preferences, needs, and values. Despite the importance of PCC, general practitioners ...
  • Redesigning peritoneal dialysis care: The introduction of frailty-informed pathways 
    Jassal, Sarbjit V.; Loon, Ismay Van (Multimed Inc., 2025-03-01)
  • Preprints in times of COVID19: the time is ripe for agreeing on terminology and good practices 
    Ravinetto, Raffaella; Caillet, Céline; Zaman, Muhammad H.; Singh, Jerome Amir; Guerin, Philippe J.; Ahmad, Aasim; Durán, Carlos E.; Jesani, Amar; Palmero, Ana; Merson, Laura; Horby, Peter W.; Bottieau, E.; Hoffmann, Tammy; Newton, Paul N. (BioMed Central, 2021-12)
    Over recent years, the research community has been increasingly using preprint servers to share manuscripts that are not yet peer-reviewed. Even if it enables quick dissemination of research findings, this practice raises ...
  • Non-classical monocytes are associated with functional markers of left ventricular diastolic dysfunction and heart failure with preserved ejection fraction 
    Kessler, Elise L; Dal Canto, Elisa; Diez-Benavente, Ernest; van Ommen, Anne-Mar; Kapteijn, Daniek; Glade, Marleen C; Bekkering, Siroon; Haitjema, Saskia; Valstar, Gideon; Cramer, Maarten J; Rutten, Frans H; Teske, Arco J; Menken, Roxana; Hofstra, Leonard; den Ruijter, Hester M; Riksen, Niels P; de Jager, Saskia C A (Elsevier Ireland Ltd, 2025-06-15)
    BACKGROUND: Inflammatory conditions such as obesity and diabetes are linked to intermediate/non-classical monocyte activation, contributing to left ventricular diastolic dysfunction (LVDD) and heart failure with preserved ...
  • The Impact of the COVID-19 Omicron Variant on Immunocompromised Patients: ICU Admissions and Increased Mortality 
    Pander, Jan; Termorshuizen, Fabian; de Lange, Dylan W; Beekman-Hendriks, Wendy; Lanfermeijer, Josien; Bakhshi-Raiez, Ferishta; Dongelmans, Dave A (Springer Healthcare, 2025)
    INTRODUCTION: The corona virus disease 19 (COVID-19) pandemic has presented a global health challenge, and several consecutive variants of the severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2) virus have been ...
  • The Impact of Paratracheal Lymphadenectomy on Survival After Esophagectomy: A Nationwide Propensity Score Matched Analysis 
    Hagens, Eliza R C; Kingma, B Feike; van Berge Henegouwen, Mark I; Borggreve, Alicia S; Ruurda, Jelle P; van Hillegersberg, Richard; Gisbertz, Suzanne S; Dutch Upper Gastrointestinal Cancer Audit (Multidisciplinary Digital Publishing Institute (MDPI), 2025-03-05)
    Purpose: To investigate the impact of paratracheal lymphadenectomy on survival in patients undergoing an esophagectomy for cancer. The secondary objective was to assess the effect on short-term outcomes. Methods: Between ...
  • Robotic Distal Pancreatectomy with Celiac Axis Resection and SMA Divestment: A Step-by-Step Educational Video 
    Garnier, Jonathan; Javed, Ammar A.; Sacks, Greg D.; Marchetti, Alessio; Andel, Paul C.M.; Garg, Karan; Salinas, Camila Hidalgo; Morgan, Katherine A.; Wolfgang, Christopher L.; Hewitts, D. Brock (Springer New York, 2025)
    Introduction: En-bloc celiac axis resection (CAR) was first proposed by Lyon H. Appleby in 1952 for gastric cancer and later modified for pancreatic resections with gastric preservation by Nimura et al. in 1976. CAR remains ...
  • AI as an intervention: improving clinical outcomes relies on a causal approach to AI development and validation 
    Joshi, Shalmali; Urteaga, Iñigo; Van Amsterdam, Wouter A.C.; Hripcsak, George; Elias, Pierre; Recht, Benjamin; Elhadad, Noémie; Fackler, James; Sendak, Mark P.; Wiens, Jenna; Deshpande, Kaivalya; Wald, Yoav; Fiterau, Madalina; Lipton, Zachary; Malinsky, Daniel; Nayan, Madhur; Namkoong, Hongseok; Park, Soojin; Vogt, Julia E.; Ranganath, Rajesh (Oxford University Press, 2025-03-01)
    The primary practice of healthcare artificial intelligence (AI) starts with model development, often using state-of-the-art AI, retrospectively evaluated using metrics lifted from the AI literature like AUROC and DICE ...
  • Hand function impairment in Systemic sclerosis: Outcomes, Mechanisms and Experience (HANDSOME) - a longitudinal observational multicentre study protocol 
    Greveling, Mark; Ong, Voon H; Denton, Christopher; Foppen, Wouter; Herman, Amin; Jeffries-Owen, Nick; Kortekaas, Marion; Masselink, Ilse; Mulder, Douwe J; Schriemer, Rita; Vonk, Madelon C; de Vries-Bouwstra, Jeska K; Welsing, Paco; Mastbergen, Simon; Spierings, Julia (BMJ Publishing Group, 2025-03-13)
    INTRODUCTION: The majority of all patients with systemic sclerosis (SSc) experience hand function impairment. The exact cause for this impairment is yet unknown. As impaired hand function hugely impacts daily functioning ...
  • What do Professionals Think of Specific Care Recommendations for Vascular Cognitive Impairment?: A Delphi Study With Health Care Professionals 
    van de Schraaf, Sara A J; Rhodius-Meester, Hanneke F M; Muller, Majon; Visser-Meily, Johanna M A; de Vugt, Marjolein E; Sizoo, Eefje M; Hertogh, Cees M P M (Elsevier, 2025-05)
    OBJECTIVES: Vascular cognitive impairment (VCI) is an umbrella term covering all cognitive impairment from mild cognitive deficits to dementia due to vascular etiologies. VCI is highly prevalent within dementia and stroke ...
  • Post-COVID microvascular dysfunction in hospitalized COVID-19 survivors is associated with acute disease severity and persistent cognitive complaints 
    van der Knaap, Noa; Klinkhammer, Simona; Postma, Alida A; Visser-Meily, Johanna M A; Horn, Janneke; van Heugten, Caroline M; Voorter, Paulien H M; van der Thiel, Merel M; Drenthen, Gerhard S; Backes, Walter H; van Rosmalen, Frank; van Santen, Susanne; van Bussel, Bas C T; van der Horst, Iwan C C; Linden, David E J; Ariës, Marcel J H; Jansen, Jacobus F A (Elsevier, 2025-05-15)
    OBJECTIVE: Coronavirus disease 2019 (COVID-19) is known to have adverse effects on the brain's vasculature in some patients. After recovery of the infection, vascular abnormalities may persist, but it remains unclear which ...
  • Stroke etiology and white matter burden in women with and without migraine 
    Wilms, Anne E.; van der Weerd, Nelleke; van Harten, Thijs W.; Linstra, Katie M.; van Os, Hendrikus J.A.; de Boer, Irene; Kruit, Mark C.; Maassen van den Brink, Antoinette; Wermer, Marieke J.H.; Terwindt, Gisela M.; On behalf of the CREW-consortium (Springer Verlag Italia, 2025)
    Background: Women with migraine, especially with aura (MA), have a higher risk of white matter hyperintensities (WMH) and ischemic stroke. We aimed to assess differences in stroke etiology between women with and without ...
  • Transcending the Language Barrier 
    Huisman, Frank (Brill, 2021)
  • A World South-Side Up? 
    Huisman, Frank; Tomes, Nancy (Brill, 2021)
    In an attempt to decolonize (the history of) global health, this paper aims to do three things. First, it claims that transposing the Enlightenment notion of a social contract in public health from a European to a global ...
  • Low psychosocial burden in patients with paraganglioma syndrome: results from the Head and Neck Paraganglioma Registry in a single center 
    de Bresser, Carolijn J M; Rijken, Johannes A; van Treijen, Mark J C; van Nesselrooij, Bernadette P M; de Ridder, Mischa; de Bree, Remco; de Borst, Gert J; Petri, Bart-Jeroen; van Leeuwaarde, Rachel S (Oxford University Press, 2025-03)
    OBJECTIVE: Autosomal dominant variants in the succinate dehydrogenase gene (SDHx) are responsible for ∼50% of the development of hereditary paragangliomas and pheochromocytomas (PPGLs). Limited research has been conducted ...
  • Do acute postoperative seizures predict epilepsy surgery outcome?: a scoping review 
    van Maanen, Sebastiaan E A; Zijlmans, Maeike J M; van Eijsden, Pieter; van der Salm, Sandra M A (Springer, 2025-03-13)
    BACKGROUND: Acute postoperative seizures (APOS) are common phenomena following resective epilepsy surgery and can be categorized as running-down (RDS) or running-up seizures (RUS). This differentiation is made retrospectively, ...