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UMC Repository: Recent submissions

  • Safety and activity of talquetamab in patients with relapsed or refractory multiple myeloma (MonumenTAL-1): a multicentre, open-label, phase 1-2 study 
    Chari, Ajai; Touzeau, Cyrille; Schinke, Carolina; Minnema, Monique C; Berdeja, Jesus G; Oriol, Albert; van de Donk, Niels W C J; Rodríguez-Otero, Paula; Morillo, Daniel; Martinez-Chamorro, Carmen; Mateos, María-Victoria; Costa, Luciano J; Caers, Jo; Rasche, Leo; Krishnan, Amrita; Ye, Jing Christine; Karlin, Lionel; Lipe, Brea; Vishwamitra, Deeksha; Skerget, Sheri; Verona, Raluca; Ma, Xuewen; Qin, Xiang; Ludlage, Hein; Campagna, Michela; Masterson, Tara; Hilder, Brandi; Tolbert, Jaszianne; Renaud, Thomas; Goldberg, Jenna D; Kane, Colleen; Heuck, Christoph; San-Miguel, Jesus; Moreau, Philippe (Lancet Publishing Group, 2025-04)
    Background: Talquetamab is the first GPRC5D × CD3 bispecific antibody approved for relapsed or refractory multiple myeloma. In phase 1 of the MonumenTAL-1 study, initial results of subcutaneous talquetamab 0·4 mg/kg once ...
  • Diet, fruit and vegetables and One Health: benefits for health, environment, society and the consumer—proceedings of the 9th edition of EGEA conference 
    Komati, Nathalie; Riboli, Elio; Dore, Joël; Boyland, Emma; Cravedi, Jean Pierre; Folkvord, Frans; Lecerf, Jean Michel; Lescourret, Françoise; Peeters, Alain; Reynolds, Christian; Alles, Benjamin; Amiot, Marie Josèphe; Binard, Philippe; Delzenne, Nathalie; Forouhi, Nita; Giner, Céline; Giyose, Boitshepo; Gonzalez, Carmen Gloria; Gunter, Marc J.; Kahane, Rémi; Herforth, Anna; Hermans, Roel; Intrigliolo, Diego S.; Montanaro, Giuseppe; Neri, Davide; Nicklaus, Sophie; Santacoloma, Pilar; Sauvaitre, Daniel; Selosse, Marc André; Smits, Tim; Stranges, Saverio; Thivel, David; Toledo, Piedad Coscollá; Van Lieshout, Machteld; Verschuren, W. M.Monique; Wickramasinghe, Kremlin; Zeinstra, Gertrude; Chambrier, Claire; Calvarin, Johanna; Tailliez, Delphine (Springer Science and Business Media Deutschland GmbH, 2025-04)
    Purpose: To present the outcomes of the EGEA Conference on the state of knowledge regarding the contribution of diets rich in fruit and vegetables (FV) to human and planetary health, commonly included in the One Health ...
  • A novel vascularized urethra-on-a-chip model 
    Casademont-Roca, Aina; Xing, Zhentao; Bernardi, Murillo; Rookmaker, Maarten; de Kort, Laetitia; de Graaf, Petra (Nature Publishing Group, 2025-03-07)
    The male urethra transports urine and semen. Any disease of the male urethra, hindering normal voiding or ejaculation, has a major impact on quality of life. Urethral stricture disease is common and molecular research into ...
  • Fast whole brain relaxometry with Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) at 3 T: a retrospective cohort study 
    Schilder, Martin B.; Mandija, Stefano; Jacobs, Sarah M.; Kleinloog, Jordi P.D.; Liu, Hanna; van der Heide, Oscar; Köktaş, Beyza; D’Agata, Federico; Keil, Vera C.W.; Vonken, Evert Jan P.A.; Dankbaar, Jan Willem; Hendrikse, Jeroen; Snijders, Tom J.; van den Berg, Cornelis A.T.; van der Kolk, Anja G.; Sbrizzi, Alessandro (Springer-Verlag, 2025-04)
    Objective: To report T1/T2-values of normal and normal appearing brain tissues (NBTs, healthy volunteers; NABTs, patients) acquired with a whole-brain 5-minute Magnetic Resonance Spin TomogrAphy in Time-domain (MR-STAT) ...
  • Further Considerations on Corticosteroid Use in Premature Infants 
    Groenendaal, Floris (American Medical Association, 2025)
  • Postmortem diagnostics in sudden unexpected death in infants and children: use and utility 
    Pries, A. M.; van der Gugten, A. C.; Moll, H. A.; Klein, W. M.; Vlaardingerbroek, H.; Verbruggen, K. T.; Semmekrot, B.; Ruskamp, J. M.; Puiman, P. J.; Levelink, B.; Fuijkschot, J.; Edelenbos, E.; Custers, A.; PESUDIC Collaborative (Springer-Verlag, 2025-03-05)
    Sudden unexpected death in infants (SUDI) and children (SUDC) requires thorough investigation to identify causes and prevention strategies. In the Netherlands, these deaths are investigated using the standardized postmortem ...
  • Two unrelated distal genes activated by a shared enhancer benefit from localizing inside the same small topological domain 
    Huang, Yike; Verstegen, Marjon J.A.M.; Tjalsma, Sjoerd J.D.; Krijger, Peter H.L.; Gupta, Kavvya; Park, Minhee; Boettiger, Alistair; de Laat, Wouter (Cold Spring Harbor Laboratory Press, 2025-03-01)
    Enhancers are tissue-specific regulatory DNA elements that can activate transcription of genes over distance. Their target genes most often are located in the same contact domain—chromosomal entities formed by cohesin DNA ...
  • Aortic valve repair in adults: long-term clinical outcomes and echocardiographic evolution in different valve repair techniques 
    Zito, Francesco; Veen, Kevin M.; Melina, Giovanni; Lansac, Emmanuel; Schäfers, Hans Joachim; de Kerchove, Laurent; Takkenberg, Johanna J.M.; Kluin, Jolanda; Mokhles, M. Mostafa (2025-03-01)
    OBJECTIVES: Aortic valve repair/sparing techniques have been established as effective treatments for aortic regurgitation and/or aortic aneurysms. However, concerns remain regarding long-term durability, reproducibility ...
  • Pop-off mechanisms in fetal megacystis: extravasation, umbilical cord cyst, ureterocele and megaureter 
    Brinkman, L. A.M.; Duin, L. K.; Adama van Scheltema, P. N.; Cohen-Overbeek, T. E.; Pajkrt, E.; Bekker, M. N.; Willekes, C.; Verweij, E. J.T.; Bilardo, C.; Fontanella, F. (John Wiley & Sons Inc., 2025-04)
    Objective: To analyze comprehensively the incidence, antenatal ultrasound characteristics and prognostic implications of antenatal pop-off mechanisms of the fetal urinary system in pregnancies with suspected fetal megacystis. ...
  • Sodium azide (NaN3) intoxication, “the man who lived”: potential effective antidote and treatment strategy 
    Geerdink, Jasper X.; van der Wal, Greetje; de Jong, Lutea A.A.; Olyslager, Erik J.H.; van den Goorbergh, Thomas W.; Kluijtmans, Leo A.J.; Spronk, Peter E. (Springer Science + Business Media, 2025-03-07)
    This case report describes the successful treatment of a suicide attempt involving the ingestion of a supralethal dose of sodium azide (NaN3), presenting a prospective novel antidote and therapeutic approach. Treatment ...
  • Extracellular vesicles for drug delivery: A major interest for the Journal of Controlled Release 
    Vader, Pieter (Elsevier, 2025-05-10)
  • Patient-reported outcomes three months after treatment of metacarpal and phalangeal fractures or dislocations a multicentre snapshot study 
    de Haas, L. E.M.; van de Lücht, V. A.P.; van Hoorn, B. T.; Salentijn, D. A.; Groenwold, R. H.H.; Schep, N. W.L.; Heijl, M.; Snapshot Hand Fractures Collaborative Study Group (British Editorial Society of Bone and Joint Surgery, 2025-02)
    Aims To evaluate patient-reported outcomes three months after treatment of metacarpal and phalangeal fractures or dislocations, and to identify factors that are associated with worse patient-reported outcomes. Methods This ...
  • Extracellular vesicles from the lung pro-thrombotic niche drive cancer-associated thrombosis and metastasis via integrin beta 2 
    Lucotti, Serena; Ogitani, Yusuke; Kenific, Candia M.; Geri, Jacob; Kim, Young Hun; Gu, Jinghua; Balaji, Uthra; Bojmar, Linda; Shaashua, Lee; Song, Yi; Cioffi, Michele; Lauritzen, Pernille; Joseph, Oveen M.; Asao, Tetsuhiko; Grandgenett, Paul M.; Hollingsworth, Michael A.; Peralta, Christopher; Pagano, Alexandra E.; Molina, Henrik; Lengel, Harry B.; Dunne, Elizabeth G.; Jing, Xiaohong; Schmitter, Madeleine; Borriello, Lucia; Miller, Thomas; Zhang, Haiying; Romin, Yevgeniy; Manova, Katia; Paul, Doru; Remmel, H. Lawrence; O'Reilly, Eileen M.; Jarnagin, William R.; Kelsen, David; Castellino, Sharon M.; Giulino-Roth, Lisa; Jones, David R.; Condeelis, John S.; Pascual, Virginia; Bussel, James B.; Boudreau, Nancy; Matei, Irina; Entenberg, David; Bromberg, Jacqueline F.; Simeone, Diane M.; Lyden, David (Elsevier, 2025-03-20)
    Cancer is a systemic disease with complications beyond the primary tumor site. Among them, thrombosis is the second leading cause of death in patients with certain cancers (e.g., pancreatic ductal adenocarcinoma [PDAC]) ...
  • Master classes of the tenth international brain-computer interface meeting: showcasing the research of BCI trainees 
    Cernera, Stephanie; Gemicioglu, Tan; Berezutskaya, Julia; Csaky, Richard; Verwoert, Maxime; Polyakov, Daniel; Papadopoulos, Sotirios; Spagnolo, Valeria; Astudillo, Juliana Gonzalez; Kumar, Satyam; Alawieh, Hussein; Kelly, Dion; Keough, Joanna R.G.; Minhas, Araz; Dold, Matthias; Han, Yiyuan; McClanahan, Alexander; Mustafa, Mousa; Gonzalez-Espana, Juan Jose; Garro, Florencia; Vujic, Angela; Kacker, Kriti; Kapeller, Christoph; Geukes, Simon; Verbaarschot, Ceci; Wimmer, Michael; Sultana, Mushfika; Ahmadi, Sara; Herff, Christian; Sburlea, Andreea Ioana; Jeunet, Camille; Thompson, David E.; Semprini, Marianna; Andersen, Richard; Stavisky, Sergey; Kinney-Lang, Eli; Lotte, Fabien; Thielen, Jordy; Chen, Xing; Peterson, Victoria; Gunduz, Aysegul; Vaughan, Theresa; Valeriani, Davide (IOP Publishing Ltd., 2025-04-01)
    The Tenth International brain-computer interface (BCI) meeting was held June 6-9, 2023, in the Sonian Forest in Brussels, Belgium. At that meeting, 21 master classes, organized by the BCI Society’s Postdoc & Student ...
  • Structure and pH Dependence of Membranolytic Mechanisms by Truncated Oxidized Phospholipids 
    Xie, Min; Derks, Maik G.N.; Koch, Eveline H.W.; van Boven, C. Bjorn; Janlad, Minchakarn; Bagheri, Behnaz; Xu, Zexi; Kovryzhenko, Daria; van Walree, Cornelis A.; Sobota, Ana; Weingarth, Markus; Wong-Ekkabut, Jirasak; Karttunen, Mikko; Breukink, Eefjan; Killian, J. Antoinette; Sonnen, Andreas F.P.; Lorent, Joseph H. (American Chemical Society, 2025-03-19)
    Membrane lipid oxidation is a universal process that occurs in situations of oxidative stress and is encountered in numerous physiological and pathological situations. Oxidized truncated phospholipids make up a large part ...
  • Visually induced motion sickness correlates with on-road car sickness while performing a visual task 
    Irmak, Tugrul; de Winkel, Ksander N.; Happee, Riender (Springer-Verlag, 2025-04)
    Previous literature suggests that the motion sickness susceptibility questionnaire (MSSQ) is inadequate for prediction of motion sickness under naturalistic driving conditions. In this study, we investigated whether visually ...
  • The fourth report of the European Registry for Patients with Mechanical Circulatory Support (EUROMACS) of the European Association for Cardiothoracic Surgery: focus on standardized outcome ratios 
    Veen, Kevin M.; Ahmed, Mazen; Stark, Christoffer; Botta, Luca; Anastasiadis, Kyriakos; Bernhardt, Alexander; Berchtold-Herz, Michael; Caliskan, Kadir; Reineke, David; Damman, Kevin; Fiane, Arnt; Gkouziouta, Angeliki; Gollmann-Tepekoyl, Can; Najjar, Emil; Hulman, Michal; Iacovoni, Attilio; Loforte, Antonio; Merkely, Bela; Musumeci, Francesco; Comisso, Marina; Nemec, Petr; Netuka, Ivan; Ozbaran, Mustafa; Potapov, Evgenij; Pya, Yuri; Rabago, Gregorio; Ramjankhan, Faiz; Scandroglio, Anna Mara; Pieri, Marina; Reichenspurner, Hermann; Dashkevich, Alexey; Stockman, Bernard; Vanderheyden, Marc; Tops, Laurens; Wahlers, Thorsten; Przybyłowski, Piotr; Zimpfer, Daniel; Løgstrup, Brian Bridal; Santer, David; Farber, Gloria; Gummert, Jan; Meyns, Bart; de By, Theo M.M.H.; Schoenrath, Felix (2025-02-01)
    OBJECTIVES: This 4th report aimed to provide insights into patient characteristics, outcomes and standardized outcome ratios of patients implanted with durable Mechanical Circulatory Support across participating centres ...
  • Efficacy of the PanCareFollowUp eHealth Lifestyle Intervention for Survivors of Childhood, Adolescent and Young Adult Cancer 
    van den Oever, Selina R.; Bouwman, Eline; van der Pal, Helena J.H.; Steensma, Philippa C.; Araujo-Soares, Vera; Brown, Morven; Kepak, Tomas; Kepakova, Katerina; Fiocco, Marta; Fremouw, Lucy M.M.; Koopman, Maria M.W.; van Litsenburg, Raphaële R.L.; van der Torre, Patrick; Wilbers, Joyce; Skinner, Roderick; Kremer, Leontien C.M.; Loonen, Jacqueline; Pluijm, Saskia M.F.; the PanCareFollowUp consortium (John Wiley & Sons Inc., 2025-03)
    Purpose: A healthy lifestyle may prevent or mitigate late effects in childhood, adolescent and young adult (CAYA) cancer survivors. To support survivors in adopting healthier behaviours, the PanCareFollowUp (PCFU) Lifestyle ...
  • Safety, Feasibility, and Diagnostic Yield of Invasive Coronary Function Testing: Netherlands Registry of Invasive Coronary Vasomotor Function Testing 
    Crooijmans, Caïa; Jansen, Tijn P.J.; Meeder, Joan G.; Woudstra, Janneke; Meuwissen, Martijn; De Vos, Annemiek M.J.; Paradies, Valeria; Olde Bijvank, Els G.M.; Winkler, Patty; Vos, Nicola S.; Arkenbout, Karin; Woudstra, Pier; Stoel, Martin G.; Van De Hoef, Tim P.; Van Den Oord, Stijn C.H.; Widdershoven, Jos W.M.G.; Remkes, Wouter; Cetinyurek-Yavuz, Aysun; Den Ruijter, Hester M.; Onland-Moret, N. Charlotte; Boersma, Eric; Beijk, Marcel A.M.; Appelman, Yolande; Piek, Jan J.; Konst, Regina E.; Maas, Angela H.E.M.; Van Royen, Niels; Dimitriu-Leen, Aukelien C.; Elias-Smale, Suzette E.; Damman, Peter; The NL-CFT Investigators (American Medical Association, 2025)
    Importance: Patients with angina and no obstructive coronary artery disease frequently have coronary vasomotor dysfunction as underlying pathophysiological mechanism, comprising epicardial spasm, microvascular spasm, and/or ...
  • Cognitive impairment in CKD patients: a guidance document by the CONNECT network 
    Bolignano, Davide; Simeoni, Mariadelina; Hafez, Gaye; Pepin, Marion; Gallo, Antonio; Altieri, Manuela; Liabeuf, Sophie; Giannakou, Konstantinos; De Ananya, A.; Capasso, Giovambattista; CONNECT Action (Cognitive Decline in Nephro-Neurology European Cooperative Target) collaborators (Oxford University Press, 2025-02-01)
    Cognitive impairment is a prevalent and debilitating complication in patients with chronic kidney disease (CKD). This position paper, developed by the Cognitive Decline in Nephro-Neurology: European Cooperative Target ...