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Now showing items 24061-24080 of 40729

Optimizing the Design and Conduct of Clinical Trials for Amyotrophic Lateral Sclerosis

van Eijk, Ruben (Utrecht University, 2019-09-17)

Background: Amyotrophic Lateral Sclerosis (ALS) is a rapidly progressive neurodegenerative disorder leading to muscle weakness and respiratory failure, with death following, on average, within three years after symptom ...
Tacrolimus pharmacokinetics and toxicity in the first days after heart and lung transplantation

Sikma, MA (Utrecht University, 2019-09-19)

The objectives of this thesis were to gain insight into how pharmacokinetics early after heart and lung transplantation affect the risk of tacrolimus (nephro-)toxicity. The authors used a population pharmacokinetic model ...
Advance to GO: Regulation of mitotic progression by the spindle checkpoint kinase MPS1

Pachis, Spyridon (Utrecht University, 2019-09-24)

Due to its extreme importance in maintaining a stable genome, chromosome segregation is highly regulated and complex process which is driven by the mitotic spindle. The spindle is comprised of microtubules whose role is ...
Putting the pieces together: The causes and consequences of de novo structural variation

Middelkamp, Sjors (Utrecht University, 2019-09-17)

DNA contains all the information for the development of a single fertilized egg cell into a complex organism containing billions of cells. Some changes in the DNA code can disturb the normal development of an embryo, which ...
To boost or not to boost: Improving quality of life after rectal cancer

Couwenberg, AM (Utrecht University, 2019-09-26)

For most patients with rectal cancer, treatment consists of surgical resection of the rectum, which is preceded by (chemo)radiotherapy depending on the disease stage. This treatment can have a negative effect on the quality ...
Surgical treatment of hypertension: Preoperative work-up and surgical treatment of primary aldosteronism in current daily practice

Vorselaars, WMCM (Utrecht University, 2019-09-19)

Primary aldosternism (PA) is the most common cause of secondary hypertension and is due to an inappropriate production of aldosterone by one or both adrenal glands. Approximately 5% of patients with hypertension suffers ...
The dynamic interaction between host and pathogens after trauma

Hellebrekers, Pien (Utrecht University, 2019-08-27)

The neutrophil is the first line of defense against invading bacteria. Neutrophils are recognized by its granules and characteristic nuclear segmentation. Neutrophils’ main functions are to phagocytize and, after fusion ...
Modeling Microglia in Schizophrenia: Illumination of the Immune Perspective

Ormel, Paul (Utrecht University, 2019-08-28)

The immune system is the defense system of the body and protects against body entering pathogens. The brain features its own immune cell, named microglia. These microglia have been implicated in various psychiatric diseases, ...
Sex hormones and jumping heart beats

van der Heyden, Marcel A G; Vos, Marc A (Wiley-Blackwell, 2019-06)
Computational Identification of Novel Kir6 Channel Inhibitors

Chen, Xingyu; Garon, Arthur; Wieder, Marcus; Houtman, Marien J C; Zangerl-Plessl, Eva-Maria; Langer, Thierry; van der Heyden, Marcel A G; Stary-Weinzinger, Anna (Frontiers Media S. A., 2019-05-24)

KATP channels consist of four Kir6.x pore-forming subunits and four regulatory sulfonylurea receptor (SUR) subunits. These channels couple the metabolic state of the cell to membrane excitability and play a key role in ...
The autoimmune-associated single nucleotide polymorphism within PTPN22 correlates with clinical outcome after lung transplantation

Budding, Kevin; Van Setten, Jessica; Van De Graaf, Eduard A.; Van Rossum, Oliver A.; Kardol-Hoefnagel, Tineke; Kwakkel-Van Erp, Johanna M.; Oudijk, Erik Jan D.; Hack, C. Erik; Otten, Henderikus G. (Frontiers Media S. A., 2019-01-17)

Obstructive chronic lung allograft dysfunction (BOS) is the major limiting factor for lung transplantation (LTx) outcome. PTPN22 is described as the hallmark autoimmunity gene, and one specific single nucleotide polymorphism ...
Effect of physical exercise on cognitive function and brain measures after chemotherapy in patients with breast cancer (PAM study): protocol of a randomised controlled trial

Witlox, Lenja; Schagen, Sanne B; de Ruiter, Michiel B; Geerlings, Mirjam I; Peeters, Petra H M; Koevoets, Emmie W; van der Wall, Elsken; Stuiver, Martijn; Sonke, Gabe; Velthuis, Miranda J; Palen, Job A M van der; Jobsen, Jan J; May, Anne M; Monninkhof, E M (BMJ Publishing Group, 2019-06-01)

INTRODUCTION: After treatment with chemotherapy, many patients with breast cancer experience cognitive problems. While limited interventions are available to improve cognitive functioning, physical exercise showed positive ...
Progress update from the hippocampal subfields group

Hippocampal Subfields Group (John Wiley & Sons Inc., 2019-12-01)

Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to ...
Association of hippocampal calcification and cardiovascular risk factors in two patient cohorts

van der Knaap, Marije J.A.; Peters, Melissa E.M.; Lucci, Carlo; Geerlings, Mirjam I.; de Jong, Pim A.; Ruigrok, Ynte M.; SMART Study Group (Elsevier Ireland Ltd, 2019-05-01)

Background and aims: Hippocampal calcification is a recently described type of intracranial calcification and might be a risk factor for ischemic stroke and dementia. Data on its risk factors and insight into the etiology ...
Ex Vivo Pilot Study of Cardiac Magnetic Resonance Velocity Mapping for Quantification of Aortic Regurgitation in a Porcine Model in the Presence of a Transcatheter Heart Valve

Kooistra, Nynke H M; Nijhoff, Freek; Abawi, Masieh; Agostoni, Pierfrancesco; Araya Roos, Daniël M; van Tuijl, Sjoerd; Blanken, Niels; Voskuil, Michiel; Doevendans, Pieter A F M; Stella, Pieter R; Leiner, Tim (Springer New York, 2019-08-15)

Accuracy of aortic regurgitation (AR) quantification by magnetic resonance (MR) imaging in the presence of a transcatheter heart valve (THV) remains to be established. We evaluated the accuracy of cardiac MR velocity mapping ...
Coronary Angiography after Cardiac Arrest without ST-Segment Elevation

Lemkes, Jorrit S; Janssens, Gladys N; van der Hoeven, Nina W; Jewbali, Lucia S D; Dubois, Eric A; Meuwissen, Martijn; Rijpstra, Tom A; Bosker, Hans A; Blans, Michiel J; Bleeker, Gabe B; Baak, Rémon; Vlachojannis, Georgios J; Eikemans, Bob J W; van der Harst, Pim; van der Horst, Iwan C C; Voskuil, Michiel; van der Heijden, Joris J; Beishuizen, Albertus; Stoel, Martin; Camaro, Cyril; van der Hoeven, Hans; Henriques, José P; Vlaar, Alexander P J; Vink, Maarten A; van den Bogaard, Bas; Heestermans, Ton A C M; de Ruijter, Wouter; Delnoij, Thijs S R; Crijns, Harry J G M; Jessurun, Gillian A J; Oemrawsingh, Pranobe V; Gosselink, Marcel T M; Plomp, Koos; Magro, Michael; Elbers, Paul W G; van de Ven, Peter M; Oudemans-van Straaten, Heleen M; van Royen, Niels (Massachussetts Medical Society, 2019-04-11)

BACKGROUND Ischemic heart disease is a major cause of out-of-hospital cardiac arrest. The role of immediate coronary angiography and percutaneous coronary intervention (PCI) in the treatment of patients who have been ...
Safety of Carotid Revascularization in Patients With a History of Coronary Heart Disease

Carotid Stenosis Trialists’ Collaboration (Lippincott Williams & Wilkins, 2019-02-01)

Background and Purpose- We investigated whether procedural stroke or death risk of carotid artery stenting (CAS) compared with carotid endarterectomy (CEA) is different in patients with and without history of coronary heart ...
International Consultation on Incontinence 2016; Executive summary: Urodynamic testing

Rosier, Peter F W M; Kuo, Hann-Chorng; De Gennaro, Mario; Gammie, Andrew; Finazzi Agro, Enrico; Kakizaki, Hidehiro; Hashim, Hashim; Toozs-Hobson, Philip (John Wiley & Sons Inc., 2019-02-01)

AIMS: The International Consultation on Incontinence has published an update of the recommendations for the diagnosis and management of urine incontinence (ICI2016). This manuscript summarizes the consultations ...
Re: Drake M.J.: Fundamentals of terminology in lower urinary tract function.

Rosier, Peter F W M (John Wiley & Sons Inc., 2019-02-01)
Clinical epidemiology: Detrusor voiding contraction maximum power, related to ageing

Rosier, Peter F W M; Ten Donkelaar, C S; de Kort, L M O (Elsevier, 2019-02-01)

Objective: To report clinical epidemiology of detrusor (bladder) muscle contraction maximum related to ageing in patients referred with signs and symptoms of lower urinary tract dysfunction. Study Design and Setting: One ...

Now showing items 24061-24080 of 40729