Progress update from the hippocampal subfields group
Hippocampal Subfields Group
(2019) Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, volume 11, pp. 439 - 449
(Article)
Abstract
Introduction: Heterogeneity of segmentation protocols for medial temporal lobe regions and hippocampal subfields on in vivo magnetic resonance imaging hinders the ability to integrate findings across studies. We aim to develop a harmonized protocol based on expert consensus and histological evidence. Methods: Our international working group, funded by the EU
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Joint Programme-Neurodegenerative Disease Research (JPND), is working toward the production of a reliable, validated, harmonized protocol for segmentation of medial temporal lobe regions. The working group uses a novel postmortem data set and online consensus procedures to ensure validity and facilitate adoption. Results: This progress report describes the initial results and milestones that we have achieved to date, including the development of a draft protocol and results from the initial reliability tests and consensus procedures. Discussion: A harmonized protocol will enable the standardization of segmentation methods across laboratories interested in medial temporal lobe research worldwide.
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Keywords: Cytoarchitecture, Hippocampus, Histology, Human, Neuroanatomy, Neuroimaging, Structural imaging, Volumetry, ex vivo, Clinical Neurology, Psychiatry and Mental health
ISSN: 2352-8729
Publisher: John Wiley & Sons, Ltd.
Note: Funding Information: This work is the product of an EU Joint Programme—Neurodegenerative Disease Research (JPND) project. The project is supported by France, Agence National de la Recherché, under the aegis of JPND — www.jpnd.eu . R.K.O. also acknowledges funding support from the Alzheimer Society of Canada, Natural Sciences and Engineering Research Council of Canada (NSERC), and Canadian Institutes of Health Research (CIHR). The work on this article was also supported by NIH grant R01 AG-011230 to Naftali Raz, NIH grant R01 AG-055121 to Lei Wang, NIH grant R01 AG-056014 to Paul Yushkevich, and NIH grant R01 AG-034613 to Craig Stark. M.M.C. receives salary support from the Fonds du Recherches Santés Québec and also acknowledges support from NSERC , Weston Brain Institute , and CIHR . The authors would like to acknowledge Aurélia Cognet for her assistance with reimbursement of travel costs from the JPND, Christine Smith, and Manuella Yassa for workshop planning, and Madigan Lavery for administrative assistance. Funding Information: This work is the product of an EU Joint Programme—Neurodegenerative Disease Research (JPND) project. The project is supported by France, Agence National de la Recherché, under the aegis of JPND—www.jpnd.eu. R.K.O. also acknowledges funding support from the Alzheimer Society of Canada, Natural Sciences and Engineering Research Council of Canada (NSERC), and Canadian Institutes of Health Research (CIHR). The work on this article was also supported by NIH grant R01 AG-011230 to Naftali Raz, NIH grant R01 AG-055121 to Lei Wang, NIH grant R01 AG-056014 to Paul Yushkevich, and NIH grant R01 AG-034613 to Craig Stark. M.M.C. receives salary support from the Fonds du Recherches Santés Québec and also acknowledges support from NSERC, Weston Brain Institute, and CIHR. The authors would like to acknowledge Aurélia Cognet for her assistance with reimbursement of travel costs from the JPND, Christine Smith, and Manuella Yassa for workshop planning, and Madigan Lavery for administrative assistance. Publisher Copyright: © 2019 The Authors
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