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Advances in perinatal stroke: From early prediction to future therapies

Wagenaar, Nienke (Utrecht University, 2019-09-26)

Imaging and continuous monitoring of the brain, as well as clinical movement assessment of the upper limbs, are tools to accurately predict future development, already within the first days to weeks after a perinatal stroke. ...
Cochlear implants: Bilateral implantation and future indications

van Zon, Alice (Utrecht University, 2019-10-10)

The first part of this thesis focusses on the benefits of bilateral cochlear implantation. We present the results of a randomized controlled trial comparing simultaneous bilateral cochlear implantation to unilateral cochlear ...
Regulatory DNA and Stem Cells in Complex Genetic Diseases

Meddens, Claartje; Fuchs, Sabine (Utrecht University, 2019-10-03)

Delineating the pathogenesis of complex genetic diseases is complicated by the great variety of genetic loci, genes, cell types, environmental factors and tissues that are involved. The genetic background of complex genetic ...
Optimizing diagnosis of Transient Ischemic Attack

Dolmans, Faas (Utrecht University, 2019-10-03)

A Transient Ischemic Attack (TIA) is an important warning sign that a patient is at risk of a full stroke in the near future. Timely diagnosis and initiation of stroke preventive treatment, most notably the start of ...
On Discontinuity and Learning: Investigations of Physicians' Responses to Transitions of Patient Care Responsibility

Bowen, J.L. (Utrecht University, 2019-08-29)

Physicians routinely transition responsibility for patients to other physicians when they reach the end of work assignments or patients need more or less specialized care. Little is known about the impact of these transitions ...
Long-term urinary, sexual and cosmetic outcomes in hypospadias repair

Rijnja, Sybren Pieter (Utrecht University, 2019-09-24)

Hypospadias is a congenital defect of the penis, which occurs in one out of 200-300 newborn boys. The meatus of the urethra is not positioned at the top of the glans, but somewhere between the glans and the scrotum. Surgical ...
(Epi)genetic and biochemical determinants of methotrexate-induced oral mucositis in pediatric acute lymphoblastic leukemia

Oosterom, Natanja (Utrecht University, 2019-10-08)

Acute Lymphoblastic Leukemia (ALL) is the most frequently occurring type of cancer in childhood affecting 120 – 130 patients per year in The Netherlands. High-dose Methotrexate (HD-MTX) is an important component of pediatric ...
Cognitive Load Theory: A Critical Lens for Examining Procedural Skills Training in the Health Professions: The Case of Gastrointestinal Endoscopy

Sewell, Justin Louis (Utrecht University, 2019-08-30)

This thesis seeks to address challenges inherent to procedural teaching and learning in the health professions by considering the lens of cognitive load theory (CLT). CLT is a cognitive learning theory focused on limitations ...
Antimicrobial resistance in the general population of the Netherlands

van Veldhuizen, Gerrita (Utrecht University, 2019-09-19)

Antimicrobial resistance is worldwide common in humans and animals and is a public health threat. Bacteria (Enterobacteriaceae) producing ESBL (Extended-spectrum Beta-lactamase) or carbapenemase received lot attention in ...
Early detection of colorectal cancer: towards better surveillance

Lanschot, M.C.J. van (Utrecht University, 2019-10-29)

Colorectal cancer (CRC) is a large health problem worldwide. In the Netherlands approximately 14.000 new cases are diagnosed each year. As such, colorectal cancer is the second most common type of cancer. The disease ...
Diagnostic and prognostic value of nerve ultrasound in peripheral nerve disease

Telleman, JA (Utrecht University, 2019-09-10)

Diagnosing peripheral nerve disease and predicting disease course can be challenging. Nerve conduction studies (NCS) have been the hallmark in diagnosing nerve disease, but these are often inconclusive and require electric ...
Advancing medical devices for novel image-guided percutaneous cardiac interventions

van den Broek, Thijs (Utrecht University, 2019-09-05)

Heart failure is a complex clinical syndrome, progressive in nature, and about half of patients who develop heart failure die within 5 years of diagnosis. This is a significant economic and healthcare burden that drives ...
Prevention of severe infectious complications after colorectal surgery

Mulder, Tessa (Utrecht University, 2019-10-01)

In the Netherlands, one in ten patients who undergo colorectal surgery develops a wound infection. These infections have important consequences: they cause pain, extend the length of hospital stay and increase the risk of ...
Organoids as a tool for fundamental and translational oncology research: Can organoids guide clinical decision making?

Driehuis, Else (Utrecht University, 2019-10-01)

Organoids are mini-organs that can be grown in a petri-dish. These structures can be grown from different sources, including patient material. During my PhD, I have established the ‘recipe’ to grow organoids from the lining ...
Fractures around the shoulder girdle: Unsolved fractures?

Frima, Herman (Utrecht University, 2019-10-03)

This thesis is about the treatment of clavicle and proximal humeral fractures and is the result of a Swiss-Dutch collaboration. Clavicle and proximal humeral fractures are very common and used to be treated non-operatively. ...
Neurogenic bladder: Myelomeningocele, Occult Spina Bifida, and Tethered Cord

Dik, P; de Kort, Laetitia; Veenboer, Paul (Springer, 2018)

Spinal dysraphism occurs in patients with spina bifida aperta or occulta and will affect the functionality of bladder and sphincter complex. The incidence has changed over the past decades from 1:3000 live births to 1:6000 ...
Het FRAIL-AF onderzoek: Optimale anticoagulantia bij kwetsbare ouderen

Joosten, Linda; Wiersma, Nynke (2018)
Safety of Ticagrelor Compared to Clopidogrel after Prehospital Initiation of Treatment

Bergmeijer, Thomas O; van Oevelen, Mathijs; Janssen, Paul W A; Godschalk, Thea C; Lichtveld, Robert A; Kelder, Johannes C; Voskuil, Michiel; Mosterd, Arend; Montalescot, Gilles; Ten Berg, Jurriën M (Thieme, 2018-10)

Objectives The objective of this registry was to study the safety of prehospital initiation of ticagrelor compared with clopidogrel. Background Ticagrelor has replaced clopidogrel in many hospitals as the routinely used ...
An increase in myeloid cells after severe injury is associated with normal fracture healing: a retrospective study of 62 patients with a femoral fracture

Hesselink, Lillian; Bastian, Okan W; Heeres, Marjolein; Ten Berg, Maarten; Huisman, Albert; Hoefer, Imo E; van Solinge, Wouter W; Koenderman, Leo; van Wessem, Karlijn J P; Leenen, Luke P H; Hietbrink, Falco (Informa Healthcare, 2018-09-03)

Background and purpose—Nonunion is common in femoral fractures. Previous studies suggested that the systemic immune response after trauma can interfere with fracture healing. Therefore, we investigated whether there is a ...
Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders - CORRIGENDUM: Absence of cerebrospinal fluid antineuronal antibodies in schizophrenia spectrum disorders (The British Journal of Psychiatry (2018) (1-3) DOI: 10.1192/bjp.2018.24)

Oviedo-Salcedo, Tatiana; de Witte, Lot; Kümpfel, Tania; Kahn, René S; Falkai, Peter; Eichhorn, Peter; Luykx, Jurjen; Hasan, Alkomiet (Cambridge University Press, 2018-09)

In the reference list, number 11 is stated incorrectly. The correct reference for 11 is: Dyalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R. Clinical experience and laboratory investigations in ...

Now showing items 24001-24020 of 40729