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UMC Repository: Recent submissions

  • Monoclonal gammopathy of renal significance (MGRS) histopathologic classification, diagnostic workup, and therapeutic options 
    Amaador, K; Peeters, H; Minnema, M C; Nguyen, T Q; Dendooven, A; Vos, J M I; Croockewit, A J; van de Donk, N W C J; Jacobs, J F M; Wetzels, J F M; Sprangers, B; Abrahams, A C (Van Zuiden Communications BV, 2019-09)
    Monoclonal gammopathy of renal significance (MGRS) includes all kidney disorders caused by a monoclonal protein (M-protein) secreted by a small plasma cell clone or other B-cell clones in patients who do not meet the ...
  • Multimodality imaging for real-time image-guided left ventricular lead placement during cardiac resynchronization therapy implantations 
    Salden, Odette A.E.; van den Broek, Hans T.; van Everdingen, Wouter M.; Mohamed Hoesein, Firdaus A.A.; Velthuis, Birgitta K.; Doevendans, Pieter A.; Cramer, Maarten Jan; Tuinenburg, Anton E.; Leufkens, Paul; van Slochteren, Frebus J.; Meine, Mathias (Springer Netherlands, 2019-07-01)
    This study was performed to evaluate the feasibility of intra-procedural visualization of optimal pacing sites and image-guided left ventricular (LV) lead placement in cardiac resynchronization therapy (CRT). In fifteen ...
  • The Drug Rediscovery protocol facilitates the expanded use of existing anticancer drugs 
    van der Velden, D L; Hoes, L R; van der Wijngaart, H; van Berge Henegouwen, J M; van Werkhoven, E; Roepman, P; Schilsky, R L; de Leng, W W J; Huitema, A D R; Nuijen, B; Nederlof, P M; van Herpen, C M L; de Groot, D J A; Devriese, L A; Hoeben, A; de Jonge, M J A; Chalabi, M; Smit, E F; de Langen, A J; Mehra, N; Labots, M; Kapiteijn, E; Sleijfer, S; Cuppen, E; Verheul, H M W; Gelderblom, H; Voest, E E (Nature Research, 2019-10)
    The large-scale genetic profiling of tumours can identify potentially actionable molecular variants for which approved anticancer drugs are available1-3. However, when patients with such variants are treated with drugs ...
  • Cerebrospinal fluid lymphocytosis: a hallmark of neurological complications during checkpoint inhibition 
    Tonk, EHJ (Erwin); Snijders, TJ (Tom); Koldenhof, JJ (José); van Lindert, ASR (Anne); Suijkerbuijk, KPM (Karijn) (Elsevier Limited, 2019-11-01)
  • CLINICAL and GENETIC CHARACTERISTICS of MALE PATIENTS with RPGR-ASSOCIATED RETINAL DYSTROPHIES: A Long-Term Follow-up Study 
    Talib, Mays; Van Schooneveld, Mary J.; Thiadens, Alberta A.; Fiocco, Marta; Wijnholds, Jan; Florijn, Ralph J.; Schalij-Delfos, Nicoline E.; Van Genderen, Maria M.; Putter, Hein; Cremers, Frans P.M.; Dagnelie, Gislin; Ten Brink, Jacoline B.; Klaver, Caroline C.W.; Van Den Born, L. Ingeborgh; Hoyng, Carel B.; Bergen, Arthur A.; Boon, Camiel J.F. (Lippincott Williams & Wilkins, 2019-06-01)
    PURPOSE: To describe the phenotype and clinical course of patients with RPGR-associated retinal dystrophies, and to identify genotype-phenotype correlations. METHODS: A multicenter medical records review of 74 male patients ...
  • Emergency Department to ICU Time Is Associated With Hospital Mortality: A Registry Analysis of 14,788 Patients From Six University Hospitals in the Netherlands 
    Groenland, Carline N.L.; Termorshuizen, Fabian; Rietdijk, Wim J.R.; Van Den Brule, Judith; Dongelmans, Dave A.; De Jonge, Evert; De Lange, Dylan W.; De Smet, Anne Marie G.A.; De Keizer, Nicolette F.; Weigel, Joachim D.; Jewbali, Lucia S.D.; Boersma, Eric; Den Uil, Corstiaan A. (Lippincott Williams & Wilkins, 2019-11-01)
    Objectives: Prolonged emergency department to ICU waiting time may delay intensive care treatment, which could negatively affect patient outcomes. The aim of this study was to investigate whether emergency department to ...
  • Dog as a Model for Osteoarthritis: The FGF4 Retrogene Insertion May Matter 
    Tellegen, Anna R; Dessing, Aileen J; Houben, Kaat; Riemers, Frank M; Creemers, Laura B; Mastbergen, Simon C; Meij, Björn P; Miranda-Bedate, Alberto; Tryfonidou, Marianna A (John Wiley & Sons Inc., 2019-12)
    Osteoarthritis (OA) is a degenerative joint disease associated with chronic pain and disability in humans and companion animals. The canine species can be subdivided into non-chondrodystrophic (NCD) and chondrodystrophic ...
  • Wervelmetastasen: Op tijd signaleren en multidisciplinair handelen 
    Baumfalk, Anniek E.; Verlaan, Jorrit Jan; Kasperts, Nicolien; Amelink, G. J.Hans; Minnema, Monique C.; Snijders, Tom J. (Bohn Stafleu van Loghum, 2019-07-12)
    Early diagnosis of spinal metastases is essential. The neurological condition at the time of diagnosis determines functional outcome. Optimal treatment planning requires a multidisciplinary approach by the general practitioner, ...
  • Earlier discontinuation of TNF-α inhibitor therapy in female patients with inflammatory bowel disease is related to a greater risk of side effects 
    Schultheiss, Johannes P D; Brand, Eelco C; Lamers, Evert; van den Berg, Willemijn C M; van Schaik, Fiona D M; Oldenburg, Bas; Fidder, Herma H (Wiley-Blackwell, 2019-08)
    BACKGROUND: In rheumatoid arthritis and psoriasis female sex has been shown to be associated with discontinuation of anti-tumour necrosis factor-α (TNF-α) therapy. AIM: To retrospectively assess the association between sex ...
  • Comparison of Survival Between Patients With Single vs Multiple Primary Cutaneous Melanomas 
    El Sharouni, Mary-Ann; Witkamp, Arjen J; Sigurdsson, Vigfús; van Diest, Paul J (American Medical Association, 2019-09)
    Importance: Melanoma is one of the most rapidly increasing forms of cancer worldwide. Most studies about survival among patients with melanoma consider only the primary tumor and disregard the potential effect of multiple ...
  • Sex matters: Men with melanoma have a worse prognosis than women 
    El Sharouni, Mary-Ann; Witkamp, Arjen J; Sigurdsson, Vigfús; van Diest, Paul J; Louwman, Marieke W J; Kukutsch, Nicole A (Wiley-Blackwell, 2019-11)
    Background: In Europe, one of the highest melanoma incidences is found in the Netherlands. Like in several other European countries, females are more prone to develop melanoma as compared to males, although survival is ...
  • Oral mucosal organoids as a potential platform for personalized cancer therapy 
    Driehuis, Else; Kolders, Sigrid; Spelier, Sacha; Lõhmussaar, Kadi; Willems, Stefan M.; Devriese, Lot A.; de Bree, Remco; de Ruiter, Emma J.; Korving, Jeroen; Begthel, Harry; van Es, Johan H.; Geurts, Veerle; He, Gui Wei; van Jaarsveld, Richard H.; Oka, Rurika; Muraro, Mauro J.; Vivié, Judith; Zandvliet, Maurice M.J.M.; Hendrickx, Antoni P.A.; Iakobachvili, Nino; Sridevi, Priya; Kranenburg, Onno; van Boxtel, Ruben; Kops, Geert J.P.L.; Tuveson, David A.; Peters, Peter J.; van Oudenaarden, Alexander; Clevers, Hans (American Association for Cancer Research Inc., 2019-07)
    Previous studies have described that tumor organoids can capture the diversity of defined human carcinoma types. Here, we describe conditions for long-term culture of human mucosal organoids. Using this protocol, a panel ...
  • Differential effects of psychoactive substances on human wildtype and polymorphic T356M dopamine transporters (DAT) 
    Zwartsen, Anne; Litjens, Carlijn Hc; Hondebrink, Laura; van den Heuvel, Jeroen Jmw; Greupink, Rick; Russel, Frans Gm; de Lange, Dylan W; Legler, Juliette; Koenderink, Jan B; Westerink, Remco Hs (Elsevier Ireland Ltd, 2019-06-15)
    Many psychoactive substances affect the human dopamine (DA) reuptake transporter (hDAT). Polymorphisms in the encoding gene could affect the functionality of the transporter and consequently alter effects of psychotropic ...
  • Quality of life and fear of cancer recurrence in T1 colorectal cancer patients treated with endoscopic or surgical tumor resection 
    Dang, Hao; de Vos Tot Nederveen Cappel, Wouter H; van der Zwaan, Sarita M S; van den Akker-van Marle, M Elske; van Westreenen, Henderik L; Backes, Yara; Moons, Leon M G; Holman, Fabian A; Peeters, Koen C M J; van der Kraan, Jolein; Langers, Alexandra M J; Lijfering, Willem M; Hardwick, James C H; Boonstra, Jurjen J (Mosby Inc., 2019-03)
    BACKGROUND AND AIMS: To optimize therapeutic decision-making in early invasive colorectal cancer (T1 CRC) patients, it is important to elicit the patient's perspective next to considering medical outcome. Because empirical ...
  • Health-related quality of life in rectal cancer patients undergoing neoadjuvant chemoradiation with delayed surgery versus short-course radiotherapy with immediate surgery: a propensity score-matched cohort study 
    Couwenberg, Alice M.; Burbach, Johannes P.M.; Intven, Martijn P.W.; Consten, Esther C.J.; Schiphorst, Anandi H.W.; Smits, Anke B.; Wijffels, Niels A.T.; Heikens, Joost T.; Koopman, Miriam; van Grevenstein, Wilhemina M.U.; Verkooijen, Helena M. (Informa Healthcare, 2019-04)
    Background: Neoadjuvant chemoradiation with delayed surgery (CRT-DS) and short-course radiotherapy with immediate surgery (SCRT-IS) are two commonly used treatment strategies for rectal cancer. However, the optimal treatment ...
  • Recommended dexamethasone dose for epidural administration: response to the comments of Koetsier 
    Van Boxem, Koen; Rijsdijk, Mienke; Hans, Guy; de Jong, Jasper; Kallewaard, Jan Willem; Vissers, Kris; van Kleef, Maarten; Rathmell, James P; Van Zundert, Jan (Wiley-Blackwell, 2019-03)
    We thank Koetsier for his comments. Indeed, the dose of dexamethasone may be a point of discussion. The authors ask to review the recommended dose of 10 mg based on the study of El Abd et al.1 where 15 mg is used for ...
  • Left ventricular unloading during veno-arterial ECMO: a review of percutaneous and surgical unloading interventions 
    Donker, Dirk W.; Brodie, Daniel; Henriques, José P.S.; Broomé, Michael (SAGE Publications Ltd, 2019-03)
    Short-term mechanical support by veno-arterial extracorporeal membrane oxygenation (VA ECMO) is more and more applied in patients with severe cardiogenic shock. A major shortcoming of VA ECMO is its variable, but inherent ...
  • Safe Use of Epidural Corticosteroid Injections: Recommendations of the WIP Benelux Work Group 
    Van Boxem, Koen; Rijsdijk, Mienke; Hans, Guy; de Jong, Jasper; Kallewaard, Jan Willem; Vissers, Kris; van Kleef, Maarten; Rathmell, James P.; Van Zundert, Jan (Wiley-Blackwell, 2019-01)
    Background: Epidural corticosteroid injections are used frequently worldwide in the treatment of radicular pain. Concerns have arisen involving rare major neurologic injuries after this treatment. Recommendations to prevent ...
  • Epidemiologisch bewijs: Roken geeft licht verhoogd risico op borstkanker 
    Bakker, Marije F. (Bohn Stafleu van Loghum, 2018-08-14)
  • Targeting the TLR4-MD2 axis in systemic sclerosis 
    O'Reilly, Steven; van Laar, Jacob M (Nature Research, 2018-10)
    Inappropriate activation of Toll-like receptor 4 (TLR4) on resident fibroblasts, through the binding of damage-associated molecular patterns, is a potential driver of fibrosis in systemic sclerosis. New evidence suggests ...