Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 23241-23260 of 40729

Implementation and evaluation of the Presto combined qualitative real-time assay for Chlamydia trachomatis and Neisseria gonorrhoeae in Rwanda

Cuylaerts, Vicky; De Baetselier, Irith; Muvunyi, Claude M; Mwambarange, Lambert; Smet, Hilde; Rusine, John; Musengamana, Viateur; van de Wijgert, Janneke; Crucitti, Tania (AOSIS (Pty) Ltd, 2019-04-18)

Background: The Presto combined qualitative real-time assay for Chlamydia trachomatis and Neisseria gonorrhoeae (Presto CT/NG PCR assay) is appealing for developing countries, because it can be used with multiple DNA ...
Efficacy and Safety of Tenofovir Disoproxil Fumarate Versus Low-Dose Stavudine Over 96 Weeks: A Multicountry Randomized, Noninferiority Trial

Venter, Willem Daniel Francois; Kambugu, Andrew; Chersich, Matthew F; Becker, Stephen; Hill, Andrew; Arulappan, Natasha; Moorhouse, Michelle; Majam, Mohammed; Akpomiemie, Godspower; Sokhela, Simiso; Poongulali, Selvamuthu; Feldman, Charles; Duncombe, Chris; Ripin, David H Brown; Vos, Alinda; Kumarasamy, Nagalingeswaran (Lippincott Williams & Wilkins, 2019-02-01)

Background:Reducing doses of antiretroviral drugs, including stavudine (d4T), may lower toxicity, while preserving efficacy. There are substantial concerns about renal and bone toxicities of tenofovir disoproxil fumarate ...
Development and validation of a novel prediction model to identify patients in need of specialized trauma care during field triage: design and rationale of the GOAT study

van der Sluijs, Rogier; Debray, Thomas P A; Poeze, Martijn; Leenen, Loek P H; van Heijl, Mark (2019-06-20)

Background: Adequate field triage of trauma patients is crucial to transport patients to the right hospital. Mistriage and subsequent interhospital transfers should be minimized to reduce avoidable mortality, life-long ...
Predicting the clinical trajectory in critically ill patients with sepsis: a cohort study

MARS Consortium (Springer Science + Business Media, 2019-12-12)

BACKGROUND: To develop a mathematical model to estimate daily evolution of disease severity using routinely available parameters in patients admitted to the intensive care unit (ICU). METHODS: Over a 3-year period, we ...
Implementation and evaluation of an antimicrobial stewardship programme in companion animal clinics: A stepped-wedge design intervention study

Hopman, Nonke E.M.; Portengen, Lützen; Hulscher, Marlies E.J.L.; Heederik, Dick J.J.; Verheij, T. J.M.; Wagenaar, Jaap A.; Prins, Jan M.; Bosje, Tjerk; Schipper, Louska; Van Geijlswijk, Ingeborg M.; Broens, Els M. (Public Library of Science, 2019-11-18)

Background To curb increasing resistance rates, responsible antimicrobial use (AMU) is needed, both in human and veterinary medicine. In human healthcare, antimicrobial stewardship programmes (ASPs) have been implemented ...
Een prachtig vak

Opstelten, Wim; van der Horst, Henriëtte; Cals, Jochen; Damoiseaux, Roger; Utrecht, University (Bohn Stafleu van Loghum, 2019-11-14)
Estimated dead space fraction and the ventilatory ratio are associated with mortality in early ARDS

MARS Consortium (Springer-Verlag GmbH and Co. KG, 2019-11-21)

BACKGROUND: Indirect indices for measuring impaired ventilation, such as the estimated dead space fraction and the ventilatory ratio, have been shown to be independently associated with an increased risk of mortality. This ...
Inhalational Methanol Intoxication: Emerging Issues in the Netherlands Resulting From Illegal Drug Production

Wijnands-Kleukers, Anja P G; Dijkman, Wouter; Brogtrop, Jeroen; Kamps, Marlijn J A; De Lange, Dylan W; Sikma, Maaike A (Mosby Inc., 2019-11)
Osteoprotegerin is Higher in Sepsis Than in Noninfectious SIRS and Predicts 30-Day Mortality of SIRS Patients in the Intensive Care

Kemperman, Hans; Schrijver, Irene T; Roest, Mark; Kesecioglu, Jozef; van Solinge, Wouter W; de Lange, Dylan W (Oxford University Press, 2019-01)

BACKGROUND: Systemic inflammatory response syndrome (SIRS) is a complex disease involving multiple pathways and organs. Biomarkers reflecting these pathways and organ function could correlate with the severity of the ...
Cardiotoxicity screening of illicit drugs and new psychoactive substances (NPS) in human iPSC-derived cardiomyocytes using microelectrode array (MEA) recordings

Zwartsen, Anne; de Korte, Tessa; Nacken, Peter; de Lange, Dylan W; Westerink, Remco H S; Hondebrink, Laura (Academic Press Inc., 2019-11)

The use of recreational drugs, including new psychoactive substances (NPS), is paralleled by emergency department visits of drug users with severe cardiotoxicity. Drug-induced cardiotoxicity can be the (secondary) result ...
Feasibility and safety of extracorporeal CO 2 removal to enhance protective ventilation in acute respiratory distress syndrome: the SUPERNOVA study

On behalf of the European Society of Intensive Care Medicine Trials Group and the “Strategy of Ultra-Protective lung ventilation with Extracorporeal CO2 Removal for New-Onset moderate to severe ARDS” (SUPERNOVA) investigators (Springer-Verlag, 2019-05-01)

Purpose: We assessed feasibility and safety of extracorporeal carbon dioxide removal (ECCO 2 R) to facilitate ultra-protective ventilation (V T 4 mL/kg and P PLAT ≤ 25 cmH 2 O) in patients with moderate acute respiratory ...
Left Ventricular Unloading During Extracorporeal Membrane Oxygenation: Insights From Meta-Analyzed Observational Data Corrected for Confounders

Meuwese, Christiaan L.; Koudstaal, Stefan; Braithwaite, Sue; Hermens, Jeannine A.J.; Donker, Dirk W. (Elsevier, 2019-06-18)
Determinants of the effect of extracorporeal carbon dioxide removal in the SUPERNOVA trial: implications for trial design

for the SUPERNOVA investigators (European Society of Intensive Care Medicine trials group) and for the International ECMO Network (ECMONet) (Springer-Verlag, 2019-09-01)

Purpose: To describe the variability and determinants of the effect of extracorporeal CO2 removal (ECCO2R) on tidal volume (Vt), driving pressure (ΔP), and mechanical power (PowerRS) and to determine whether highly responsive ...
Light and noise nuisance … deciphered yet underappreciated ‘rosetta stone’ of the modern ICU?

Donker, D. W. (Netherlands Society of Intensive Care, 2019-07-01)

In everyday life, we take for granted that public authorities protect us from an unhealthy environment, including light and noise pollution. In recent years, about 1200 kilometres of noise barriers have been built alongside ...
The effect of ICU-tailored drug-drug interaction alerts on medication prescribing and monitoring: protocol for a cluster randomized stepped-wedge trial

Bakker, T; Klopotowska, J E; Eslami, S; de Lange, D W; van Marum, R; van der Sijs, H; de Jonge, E; Dongelmans, D A; de Keizer, N F; Abu-Hanna, A (BioMed Central, 2019-08-13)

BACKGROUND: Drug-drug interactions (DDIs) can cause patient harm. Between 46 and 90% of patients admitted to the Intensive Care Unit (ICU) are exposed to potential DDIs (pDDIs). This rate is twice as high as patients on ...
Reducing pain in children with cancer: Methodology for the development of a clinical practice guideline

on behalf of the Pain in Children with Cancer Guideline Development Panel (Wiley-Liss Inc., 2019-06-01)

Although pain is one of the most prevalent and bothersome symptoms children with cancer experience, evidence-based guidance regarding assessment and management is lacking. With 44 international, multidisciplinary healthcare ...
Systematic review and consensus definitions for the Standardised Endpoints in Perioperative Medicine initiative: clinical indicators

Haller, Guy; Bampoe, Sohail; Cook, Tim; Fleisher, L. A.; Grocott, Michael P.W.; Neuman, Mark; Story, D.; Myles, Paul S.; Myles, P.; Grocott, M.; Biccard, B.; Blazeby, J.; Boney, O.; Chan, M.; Diouf, E.; Fleisher, L.; Kalkman, C.; Kurz, A.; Moonesinghe, R.; Wijeysundera, D.; Gan, T. J.; Peyton, P.; Sessler, D.; Tramèr, M.; Cyna, A.; De Oliveira, G. S.; Wu, C.; Jensen, M.; Kehlet, H.; Botti, M.; Haller, G.; Cook, T.; Neuman, M.; Story, D.; Gruen, R.; Bampoe, S.; Evered, L.; Scott, D.; Silbert, B.; van Dijk, D.; Grocott, H.; Eckenhoff, R.; Rasmussen, L.; Eriksson, L.; Beattie, S.; Landoni, G.; Leslie, K.; Dieleman, S.; van Klei, W.; Jackson, S. (Oxford University Press, 2019-08-01)

Background: Clinical indicators are powerful tools to quantify the safety and quality of patient care. Their validity is often unclear and definitions extremely heterogeneous. As part of the International Standardised ...
Effect of Phenylephrine and Ephedrine on Cerebral (Tissue) Oxygen Saturation During Carotid Endarterectomy (PEPPER): A Randomized Controlled Trial

Fassaert, Leonie M.M.; de Borst, Gert J.; Pennekamp, Claire W.A.; Specken-Welleweerd, Jantine C.; Moll, Frans L.; van Klei, Wilton A.; Immink, Rogier V. (Humana Press, 2019-12-01)

BACKGROUND: Short-acting vasopressor agents like phenylephrine or ephedrine can be used during carotid endarterectomy (CEA) to achieve adequate blood pressure (BP) to prevent periprocedural stroke by preserving the cerebral ...
Adjusting for Disease Severity Across ICUs in Multicenter Studies

Brakenhoff, Timo B; Plantinga, Nienke L; Wittekamp, Bastiaan H J; Cremer, Olaf; de Lange, Dylan W; de Keizer, Nicolet F; Bakhshi-Raiez, Ferishta; Groenwold, Rolf H H; Peelen, Linda M (Lippincott Williams & Wilkins, 2019-08)

Objectives: To compare methods to adjust for confounding by disease severity during multicenter intervention studies in ICU, when different disease severity measures are collected across centers. Design: In silico simulation ...
Cumulative Prognostic Score Predicting Mortality in Patients Older Than 80 Years Admitted to the ICU

the VIP1 Study Group (Wiley-Blackwell, 2019-06-01)

OBJECTIVES: To develop a scoring system model that predicts mortality within 30 days of admission of patients older than 80 years admitted to intensive care units (ICUs). DESIGN: Prospective cohort study. SETTING: A total ...

Now showing items 23241-23260 of 40729