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UMC Repository: Recent submissions

  • Handle with care: A multidisciplinary analysis of frontline medical leadership in medical residents 
    Voogt, Judith Joke (Utrecht University, 2019-11-29)
    This thesis examined medical leadership from several perspectives using a theory-driven, mixed methods and multi-disciplinary approach. We showed that medical leadership is a loosely defined concept that is susceptible to ...
  • Impact of data processing on diffusion MR image exploration and understanding 
    Dávid, Szabolcs (Utrecht University, 2020-01-16)
    The aim of this thesis was to investigate the influence of data processing steps on the understanding and interpretation of diffusion MRI-based studies, both in basic and applied research. Diffusion MRI is the preferred ...
  • Care for community-acquired pneumonia and emerging pneumococcal serotypes 
    Vestjens, Stefan Mathias Theodorus (Utrecht University, 2020-02-06)
    Pneumonia is a common condition that frequently leads to hospitalization. In hospitalized adults Streptococcus pneumoniae, or pneumococcus, is the most prevalent bacterial pathogen causing community-acquired pneumonia ...
  • MRI safety of implants: transfer function determination from MR images 
    Tokaya, Janot Philippe (Utrecht University, 2020-01-07)
    MRI is often considered to be a risk for patients with medical implants, like pacemakers and deep brain stimulators. The heating around the electrodes of these type of implants that are in contact with human tissue to ...
  • Intra-tumoral holmium-166 therapy : Feasibility in head and neck cancer 
    Bakker, Robbert Christiaan (Utrecht University, 2020-01-15)
    Head and neck cancer (HNC) has a high incidence, the prognosis in case of advanced stage disease is poor, and over the past decades, the overall survival has only slightly increased. This thesis, provide insight into the ...
  • The extracellular matrix and angiogenesis : Two aspects that define cardiovascular health and disease 
    Louzao Martinez, Laura (Utrecht University, 2020-01-28)
    Two aspects that define cardiovascular health and disease are the extracellular matrix and angiogenesis. The extracellular matrix   During development, ECM remodeling accompanies the formation of distinct tissues. This ...
  • The 2013-2014 measles outbreak in The Netherlands: New evidence on measles epidemiology and control 
    Woudenberg, Tom (Utrecht University, 2020-01-23)
    In Chapter 2, we described the measles outbreak of 2013/14 that occurred in The Netherlands. The outbreak took mainly place within the orthodox Protestant community. In total, 2700 measles cases, 181 hospitalisations and ...
  • The 22q11.2 Deletion Syndrome as a Model for Idiopathic Scoliosis 
    Homans, Jelle Frederik (Utrecht University, 2020-01-23)
    Over a century of dedicated research has been performed on the etiology of scoliosis. One of the main problems in that research is that patients only present following the onset of scoliosis and thus truly causative research ...
  • Type 2 diabetes mellitus in patients at the memory clinic 
    Groeneveld, Onno Nicolaas (Utrecht University, 2020-01-21)
    In ageing populations, there is an increased co-occurrence of type 2 diabetes mellitus (T2DM) and dementia. Moreover, T2DM increases the risk of mild cognitive impairment (MCI) and dementia. We studied to what extent ...
  • Bradykinin driven inflammation 
    Hofman, Zonne Liza Michaëla (Utrecht University, 2020-01-09)
    Bradykinin is an inflammatory peptide that causes a local increase in vascular permeability. We have learned from patients with the disease hereditary angioedema that uncontrolled bradykinin production leads to episodes ...
  • Prognosis in glioblastoma : A clinical and translational approach 
    Berendsen, Sharon (Utrecht University, 2020-01-14)
    Glioblastoma is a highly malignant brain tumor, and currently remains an incurable disease. Despite intensive treatment strategies, patients have a poor prognosis of 12-16 months. Glioblastoma patients suffer from both an ...
  • New disease mechanisms in Arrhythmogenic Cardiomyopathy : Focus on calcium sensitive pathways 
    Opbergen, Chantal Josephina Maria van (Utrecht University, 2020-01-16)
    The heart is the most important muscular organ in the body as it provides oxygen and vital nutrients to all tissues within the body and supports excretion of waste products. Nowadays cardiovascular disease is the number ...
  • An interprofessional approach to pressure ulcer prevention: A knowledge and attitudes evaluation 
    Clarkson, Paul; Worsley, Peter R.; Schoonhoven, Lisette; Bader, Dan L. (Dove Medical Press Ltd, 2019-05-23)
    Background: Pressure ulcers (PUs) are a major burden to individuals, impacting their physical, mental and social wellbeing. While PU prevention is traditionally regarded as a nursing issue, an interprofessional approach ...
  • One-carbon metabolism biomarkers and risk of urothelial cell carcinoma in the European prospective investigation into cancer and nutrition 
    Vrieling, Alina; Bueno-De-Mesquita, H. Bas; Ros, Martine M.; Kampman, Ellen; Aben, Katja K.; Büchner, Frederike L.; Jansen, Eugène H.; Roswall, Nina; Tjønneland, Anne; Boutron-Ruault, Marie Christine; Cadeau, Claire; Chang-Claude, Jenny; Kaaks, Rudolf; Weikert, Steffen; Boeing, Heiner; Trichopoulou, Antonia; Lagiou, Pagona; Trichopoulos, Dimitrios; Sieri, Sabina; Palli, Domenico; Panico, Salvatore; Peeters, Petra H.; Weiderpass, Elisabete; Skeie, Guri; Jakszyn, Paula; Chirlaque, María Dolores; Ardanaz, Eva; Sánchez, María José; Ehrnström, Roy; Malm, Johan; Ljungberg, Börje; Khaw, Kay Tee; Wareham, Nick J.; Brennan, Paul; Johansson, Mattias; Riboli, Elio; Kiemeney, Lambertus A. (John Wiley & Sons Inc., 2019-11-01)
    Published associations between dietary folate and bladder cancer risk are inconsistent. Biomarkers may provide more accurate measures of nutrient status. This nested case–control analysis within the European Prospective ...
  • Breast cancer risk after recent childbirth: A pooled analysis of 15 prospective studies 
    Nichols, Hazel B.; Schoemaker, Minouk J.; Cai, Jianwen; Xu, Jiawei; Wright, Lauren B.; Brook, Mark N.; Jones, Michael E.; Adami, Hans Olov; Baglietto, Laura; Bertrand, Kimberly A.; Blot, William J.; Boutron-Ruault, Marie Christine; Dorronsoro, Miren; Dossus, Laure; Eliassen, A. Heather; Giles, Graham G.; Gram, Inger T.; Hankinson, Susan E.; Hoffman-Bolton, Judy; Kaaks, Rudolf; Key, Timothy J.; Kitahara, Cari M.; Larsson, Susanna C.; Linet, Martha; Merritt, Melissa A.; Milne, Roger L.; Pala, Valeria; Palmer, Julie R.; Peeters, Petra H.; Riboli, Elio; Sund, Malin; Tamimi, Rulla M.; Tjønneland, Anne; Trichopoulou, Antonia; Ursin, Giske; Vatten, Lars; Visvanathan, Kala; Weiderpass, Elisabete; Wolk, Alicja; Zheng, Wei; Weinberg, Clarice R.; Swerdlow, Anthony J.; Sandler, Dale P. (American College of Physicians, 2019-01-01)
    Background: Parity is widely recognized as protective for breast cancer, but breast cancer risk may be increased shortly after childbirth. Whether this risk varies with breastfeeding, family history of breast cancer, or ...
  • Dietary folate intake and pancreatic cancer risk: Results from the European prospective investigation into cancer and nutrition 
    Park, Jin Young; Bueno-de-Mesquita, H. Bas; Ferrari, Pietro; Weiderpass, Elisabete; de Batlle, Jordi; Tjønneland, Anne; Kyro, Cecilie; Rebours, Vinciane; Boutron-Ruault, Marie Christine; Mancini, Francesca Romana; Katzke, Verena; Kühn, Tilman; Boeing, Heiner; Trichopoulou, Antonia; La Vecchia, Carlo; Kritikou, Maria; Masala, Giovanna; Pala, Valeria; Tumino, Rosario; Panico, Salvatore; Peeters, Petra H.; Skeie, Guri; Merino, Susana; Duell, Eric J.; Rodríguez-Barranco, Miguel; Dorronsoro, Miren; Chirlaque, Maria Dolores; Ardanaz, Eva; Gylling, Björn; Schneede, Jörn; Ericson, Ulrika; Sternby, Hanna; Khaw, Kay Tee; Bradbury, Kathryn E.; Huybrechts, Inge; Aune, Dagfinn; Vineis, Paolo; Slimani, Nadia (John Wiley & Sons Inc., 2019-04-01)
    Pancreatic cancer (PC) has an exceptionally low survival rate and primary prevention strategies are limited. Folate plays an important role in one-carbon metabolism and has been associated with the risk of several cancers, ...
  • How psychological distance of a study sample in discrete choice experiments affects preference measurement: a colorectal cancer screening case study 
    Veldwijk, Jorien; Groothuis-Oudshoorn, Catharina G M; Kihlbom, Ulrik; Langenskiöld, Sophie; Dekker, Evelien; Kallenberg, Frank G J; de Wit, G Ardine; Lambooij, Mattijs S (Dove Medical Press Ltd., 2019-02-12)
    Purpose: The purpose of this study was to investigate to what extent the outcomes of a discrete choice experiment (DCE) differ based on respondents' psychological distance to the decision at hand. Methods: A DCE questionnaire ...
  • Autoimmunity plays a role in the onset of diabetes after 40 years of age 
    Rolandsson, Olov; Hampe, Christiane S.; Sharp, Stephen J.; Ardanaz, Eva; Boeing, Heiner; Fagherazzi, Guy; Mancini, Francesca Romana; Nilsson, Peter M.; Overvad, Kim; Chirlaque, Maria Dolores; Dorronsoro, Miren; Gunter, Marc J.; Kaaks, Rudolf; Key, Timothy J.; Khaw, Kay Tee; Krogh, Vittorio; Kühn, Tilman; Palli, Domenico; Panico, Salvatore; Sacerdote, Carlotta; Sánchez, Maria José; Severi, Gianluca; Spijkerman, Annemieke M.W.; Tumino, Rosario; van der Schouw, Yvonne T.; Riboli, Elio; Forouhi, Nita G.; Langenberg, Claudia; Wareham, Nicholas J. (Springer-Verlag, 2019-11-11)
    Aims/hypothesis: Type 1 and type 2 diabetes differ with respect to pathophysiological factors such as beta cell function, insulin resistance and phenotypic appearance, but there may be overlap between the two forms of ...
  • Predicting the chances of having a baby with or without treatment at different time points in couples with unexplained subfertility 
    McLernon, D. J.; Lee, A. J.; Maheshwari, A.; Van Eekelen, R.; Van Geloven, N.; Putter, H.; Eijkemans, M. J.; Van Der Steeg, J. W.; Van Der Veen, F.; Steyerberg, E. W.; Mol, B. W.; Bhattacharya, S. (Oxford University Press, 2019-06)
    STUDY QUESTION: Can we develop a prediction model that can estimate the chances of conception leading to live birth with and without treatment at different points in time in couples with unexplained subfertility? SUMMARY ...
  • IVF for unexplained subfertility; Whom should we treat? 
    Van Eekelen, R.; Van Geloven, N.; Van Wely, M.; Bhattacharya, S.; Van Der Veen, F.; Eijkemans, M. J.; McLernon, D. J. (Oxford University Press, 2019-07)
    STUDY QUESTION: Which couples with unexplained subfertility can expect increased chances of ongoing pregnancy with IVF compared to expectant management? SUMMARY ANSWER: For couples in which the woman is under 40 years of ...