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Now showing items 22961-22980 of 40729

Exposure to Docetaxel in the Elderly Patient Population: a Population Pharmacokinetic Study

Crombag, Marie-Rose B S; Dorlo, Thomas P C; van der Pan, Ellen; van Straten, Anoek; Bergman, Andries M; van Erp, Nielka P; Beijnen, Jos H; Huitema, Alwin D R (Springer New York, 2019-12-01)

BACKGROUND: Docetaxel is commonly used in elderly patients, who are frequently diagnosed with prostate cancer. Although previous studies revealed no clinically relevant impact of older age on docetaxel pharmacokinetics ...
Mediation analysis of the relationship between type 2 diabetes and cardiovascular events and all-cause mortality: Findings from the SMART cohort

SMART Study Group (Wiley-Blackwell, 2019-08)

Aim: To quantify the magnitude and specific contributions of known cardiovascular risk factors leading to higher cardiovascular risk and all-cause mortality caused by type 2 diabetes (T2D). Methods: Mediation analysis was ...
Adverse differences in cardiometabolic risk factor levels between individuals with pre-diabetes and normal glucose metabolism are more pronounced in women than in men: The Maastricht Study

De Ritter, Rianneke; Sep, Simone J.S.; Van Der Kallen, Carla J.H.; Schram, Miranda T.; Koster, Annemarie; Kroon, Abraham A.; Van Greevenbroek, Marleen M.J.; Eussen, Simone J.P.M.; Dagnelie, Pieter C.; De Jong, Marit; Vos, Rimke C.; Woodward, Mark; Bots, Michiel L.; Peters, Sanne A.E.; Stehouwer, Coen D.A. (BMJ Publishing Group, 2019-11-15)

Objective To investigate whether adverse differences in levels of cardiovascular risk factors in women than men, already established when comparing individuals with and without diabetes, are also present before type 2 ...
Fused high b-value diffusion weighted and T2-weighted MR images in staging of pediatric Hodgkin's lymphoma: A pilot study

Spijkers, Suzanne; Nievelstein, Rutger A.J.; de Keizer, Bart; Bruin, Marrie C.A.; Littooij, Annemieke S. (Elsevier Ireland Ltd, 2019-12-01)

Purpose: To evaluate the value of fused high b-value diffusion weighted and T2-weighted MRI compared to T1-weighted imaging, T2-weighted imaging and DWI for staging pediatric Hodgkin's lymphoma. Method: 21 consecutive ...
MRI-guided pulmonary vein isolation for atrial fibrillation: What is good enough? An early health technology assessment

Wenker, Steven; Van Lieshout, Chris; Frederix, Geert; Van Der Heijden, Jeroen; Loh, Peter; Chamuleau, Steven A.J.; Van Slochteren, Frebus (BMJ Publishing Group, 2019-11-11)

Next to anticoagulation, pulmonary vein isolation (PVI) is the most important interventional procedure in the treatment of atrial fibrillation (AF). Despite widespread clinical application of this therapy, patients often ...
Self-reported work ability in breast cancer survivors; a prospective cohort study in the Netherlands

UMBRELLA Study Group (Churchill Livingstone, 2019-12-01)

Purpose: To evaluate patient-reported work ability of breast cancer patients, to compare scores with the Dutch general population, and to identify determinants of reduced work ability in breast cancer patients. Methods: ...
The use or generation of biomedical data and existing medicines to discover and establish new treatments for patients with rare diseases-recommendations of the IRDiRC Data Mining and Repurposing Task Force

IRDiRC Data Mining and Repurposing Task Force (BioMed Central, 2019-10-15)

The number of available therapies for rare diseases remains low, as fewer than 6% of rare diseases have an approved treatment option. The International Rare Diseases Research Consortium (IRDiRC) set up the multi-stakeholder ...
Prevalence and determinants of type 2 diabetes among lean African migrants and non-migrants: the RODAM study

Chilunga, Felix P; Henneman, Peter; Meeks, Karlijn Ac; Beune, Erik; Requena-Méndez, Ana; Smeeth, Liam; Addo, Juliet; Bahendeka, Silver; Danquah, Ina; Schulze, Matthias B; Spranger, Joachim; Owusu-Dabo, Ellis; Klipstein-Grobusch, Kerstin; Mannens, Marcel Mam; Agyemang, Charles (Edinburgh University Global Health Society, 2019-12)

Background Exposure to adverse conditions earlier in life-course can predispose to type 2 diabetes in adulthood, irrespective of body mass index (BMI). However, the burden of type 2 diabetes in lean Africans is not well ...
Nonfocal Transient Neurological Attacks Are Associated With Cerebral Small Vessel Disease

Heart-Brain Connection Consortium (Lippincott Williams & Wilkins, 2019-12)

Background and Purpose- Nonfocal transient neurological attacks (TNAs), such as unsteadiness, bilateral weakness, or confusion, are associated with an increased risk of stroke and dementia. Cerebral ischemia plays a role ...
Pharmacist-Psychiatrist Interventions Triggered by Clinical Decision Support System Improve Monitoring of Patients Using Lithium in a General Hospital

Van Gorp, Freek; Kuck, Emile M.; Sonnen, Max P.A.M.; Hugenholtz, Gerard W.K.; Egberts, Toine C.G.; Wilting, Ingeborg (Lippincott Williams & Wilkins, 2019-09-01)
Effect of reimbursement restriction policy on the use of benzodiazepines in the Netherlands: An interrupted time series analysis

Stoker, Lennart Jan; Heerdink, Eibert Roelof; Janssen, Richard; Egberts, Toine C.G. (BMJ Publishing Group, 2019-09-01)

Objectives Use of benzodiazepines has health risks. Reimbursement was restricted in the Netherlands from January 2009 onwards with the goal to reduce chronic use and healthcare expenditures. The aim of this study is to ...
Simultaneous Quantification of Free Adalimumab and Infliximab in Human Plasma Using a Target-Based Sample Purification and Liquid Chromatography-Tandem Mass Spectrometry

El Amrani, Mohsin; Bosman, Sabine M; Egas, Annelies C; Hack, C Erik; Huitema, Alwin D R; van Maarseveen, Erik M (Lippincott Williams & Wilkins, 2019-10-01)

Background: Therapeutic drug monitoring of tumor necrosis factor alpha (TNF-α) inhibitors such as adalimumab (ADM) and infliximab (IFX) is considered of added value for patients with systemic inflammatory diseases. In ...
Pharmacological considerations in antithymocyte globulin exposure calculation

Admiraal, Rick; de Witte, Moniek A; Huitema, Alwin; Nierkens, Stefan (Elsevier, 2019-06-01)
Tyrosine kinase inhibitor levels matter in treating chronic GVHD

van der Wagen, Lotte; Janssen, Julie; Raijmakers, Reinier; Petersen, Eefke; de Witte, Moniek; de Jong, Niels; Bellido, Mar; Meijer, Ellen; Bär, Brigitte; Jan Boelens, Jaap; Huitema, Alwin; Kuball, Jürgen (Springer Nature, 2019-07-01)

We observed a possible concentration effect relationship for nilotinib on resolution of chronic Graft versus Host disease.These data suggest therapeutic drug monitoring might be useful for patients receiving tyrosine kinase ...
Interventions for unexplained infertility: a systematic review and network meta-analysis

Wang, Rui; Danhof, Nora A; Tjon-Kon-Fat, Raissa I; Eijkemans, Marinus Jc; Bossuyt, Patrick Mm; Mochtar, Monique H; van der Veen, Fulco; Bhattacharya, Siladitya; Mol, Ben Willem J; van Wely, Madelon (John Wiley & Sons Inc., 2019-09-05)

BACKGROUND: Clinical management for unexplained infertility includes expectant management as well as active treatments, including ovarian stimulation (OS), intrauterine insemination (IUI), OS-IUI, and in vitro fertilisation ...
Implications of spirometric reference values for amyotrophic lateral sclerosis

van Eijk, Ruben P A; Bakers, Jaap N E; van Es, Michael A; Eijkemans, Marinus J C; van den Berg, Leonard H (Informa Healthcare, 2019-11)

Objective: Spirometry is commonly used as screening tool for respiratory insufficiency in neuromuscular diseases. Despite the well-known effects of reference standards on spirometric outcomes, its standardization is ...
Phenotypic factors associated with amisulpride-induced weight gain in first-episode psychosis patients (from the OPTiMiSE cohort)

Pandit, R; Cianci, D; Ter Hark, S E; Winter-van Rossum, I; Ebdrup, B H; Broberg, B V; Garcia-Portilla, M P; Bobes, J; Vinkers, C H; Kahn, R S; Guloksuz, S; Huitema, A D R; Luykx, J J (Wiley-Blackwell, 2019-09)

OBJECTIVE: Antipsychotic-induced weight gain (AiWG) is a debilitating adverse effect of most antipsychotics. First-episode psychosis patients are particularly vulnerable to the detrimental consequences of AiWG. Amisulpride ...
Development and validation of an LC-MS/MS method with a broad linear dynamic range for the quantification of tivozanib in human and mouse plasma, mouse tissue homogenates, and culture medium

Bruin, M.A.C.; Rosing, H; Lucas, L; Wang, J; Huitema, A D R; Schinkel, A H; Beijnen, J H (Elsevier, 2019-09-01)

The first bioanalytical assay for tivozanib in human and mouse plasma, mouse tissue homogenates and culture medium was developed and validated over a linear dynamic range from 0.5 to 5000 ng/mL. The extended concentration ...
European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)

Düzel, Emrah; Acosta-Cabronero, Julio; Berron, David; Biessels, Geert Jan; Björkman-Burtscher, Isabella; Bottlaender, Michel; Bowtell, Richard; Buchem, Mark V; Cardenas-Blanco, Arturo; Boumezbeur, Fawzi; Chan, Dennis; Clare, Stuart; Costagli, Mauro; de Rochefort, Ludovic; Fillmer, Ariane; Gowland, Penny; Hansson, Oskar; Hendrikse, Jeroen; Kraff, Oliver; Ladd, Mark E; Ronen, Itamar; Petersen, Esben; Rowe, James B; Siebner, Hartwig; Stoecker, Tony; Straub, Sina; Tosetti, Michela; Uludag, Kamil; Vignaud, Alexandre; Zwanenburg, Jaco; Speck, Oliver (John Wiley & Sons Inc., 2019-12)

Introduction: The goal of European Ultrahigh-Field Imaging Network in Neurodegenerative Diseases (EUFIND) is to identify opportunities and challenges of 7 Tesla (7T) MRI for clinical and research applications in ...
On the sensitivity of the diffusion MRI signal to brain activity in response to a motor cortex paradigm

De Luca, Alberto; Schlaffke, Lara; Siero, Jeroen C.W.; Froeling, Martijn; Leemans, Alexander (Wiley-Liss Inc., 2019-12-01)

Diffusion functional magnetic resonance imaging (dfMRI) is a promising technique to map functional activations by acquiring diffusion-weighed spin-echo images. In previous studies, dfMRI showed higher spatial accuracy at ...

Now showing items 22961-22980 of 40729