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Quantification of coagulation factor VIII in human plasma with liquid chromatography tandem mass spectrometry using a selective sample purification with camelid nanobodies

El Amrani, Mohsin; Donners, Anouk A.M.; Graat, Gerard; Lentjes, Eef G.; Huisman, Albert; Musson, Ruben E.A.; van Maarseveen, Erik M. (Elsevier, 2019-10-25)

Patients with hemophilia A are currently diagnosed and monitored by measuring the activity of coagulation factor VIII (FVIII) in plasma mostly with the one-stage clotting assay (OSA). Although the OSA is routinely available ...
A phase I dose escalation study of once weekly oral administration of docetaxel as ModraDoc001 capsule or ModraDoc006 tablet in combination with ritonavir

de Weger, Vincent Anne; Stuurman, Frederik E; Koolen, Stijn Lw; Moes, Johannes J; Hendrikx, Jeroen J M A; Sawicki, Emilia; Thijssen, Bas; Keessen, Marianne; Rosing, Hilde; Mergui-Roelvink, M; Huitema, Alwin D R; Nuijen, Bastiaan; Beijnen, Jos H; Schellens, Jan H M; Marchetti, Serena (American Association for Cancer Research Inc., 2019-09-15)

Purpose: Oral bioavailability of docetaxel is poor. Absorption could be improved by development of pharmaceutical formulations based on docetaxel solid dispersions, denoted ModraDoc001 capsule and ModraDoc006 tablet (both ...
Development and validation of a liquid chromatography-tandem mass spectrometry assay for nine oral anticancer drugs in human plasma

Janssen, Julie M; de Vries, Niels; Venekamp, Nikkie; Rosing, Hilde; Huitema, Alwin D R; Beijnen, Jos H (Elsevier, 2019-09-10)

A liquid chromatography-tandem mass spectrometry assay was developed and validated for the nine oral anticancer agents alectinib, cobimetinib, lenvatinib, nintedanib, osimertinib, palbociclib, ribociclib, vismodegib and ...
Phenobarbital, Midazolam Pharmacokinetics, Effectiveness, and Drug-Drug Interaction in Asphyxiated Neonates Undergoing Therapeutic Hypothermia

Favié, Laurent M.A.; Groenendaal, Floris; Van Den Broek, Marcel P.H.; Rademaker, Carin M.A.; De Haan, Timo R.; Van Straaten, Henrica L.M.; Dijk, Peter H.; Van Heijst, Arno; Simons, Sinno H.P.; Dijkman, Koen P.; Rijken, Monique; Zonnenberg, Inge A.; Cools, Filip; Zecic, Alexandra; Van Der Lee, Johanna H.; Nuytemans, Debbie H.G.M.; Van Bel, Frank; Egberts, Toine C.G.; Huitema, Alwin D.R. (S. Karger AG, 2019-08-01)

Background: Phenobarbital and midazolam are commonly used drugs in (near-)term neonates treated with therapeutic hypothermia for hypoxic-ischaemic encephalopathy, for sedation, and/or as anti-epileptic drug. Phenobarbital ...
Relevance of Endoxifen Concentrations: Absence of Evidence Is Not Evidence of Absence

Braal, C Louwrens; Beijnen, Jos H; Koolen, Stijn L W; Oomen-de Hoop, Esther; Steeghs, Neeltje; Jager, Agnes; Huitema, Alwin D R; Mathijssen, Ron H J (Lippincott Williams & Wilkins, 2019-08-01)
Radiosurgical, neurosurgical, or no intervention for cerebral cavernous malformations: A decision analysis

Rinkel, Leon A; Salman, Rustam Al-Shahi; Rinkel, Gabriel Je; Greving, Jacoba P (SAGE Publications Ltd, 2019-12-01)

INTRODUCTION: We aimed to evaluate the preferred treatment strategy for patients with symptomatic cerebral cavernous malformations (CCM). METHODS: In a decision model, we compared neurosurgical, radiosurgical, and conservative ...
Bone-marrow derived mesenchymal stromal cells infusion in therapy refractory juvenile idiopathic arthritis patients

Swart, Joost F; de Roock, Sytze; Nievelstein, Rutger A J; Slaper-Cortenbach, Ineke C M; Boelens, Jaap J; Wulffraat, Nico M (Oxford University Press, 2019-10-01)

OBJECTIVES: To compare the total number of adverse events (AEs) before and after mesenchymal stromal cell (MSC) infusion in refractory JIA and to evaluate its effectiveness. METHODS: Single-centre Proof of Mechanism Phase ...
Exposure-response modeling of tocilizumab in rheumatoid arthritis using continuous composite measures and their individual components

Bastida, Carla; Soy, Dolors; Ruiz-Esquide, Virginia; Sanmartí, Raimon; Huitema, Alwin D R (Wiley-Blackwell, 2019-08-01)

Aims: Tocilizumab has a direct effect on inflammatory markers. Therefore, composite measures for disease activity assessment in rheumatoid arthritis (RA) using these inflammatory markers may not be suitable for tocilizumab ...
Neutropenia and docetaxel exposure in metastatic castration-resistant prostate cancer patients: A meta-analysis and evaluation of a clinical cohort

de Vries Schultink, Aurelia H M; Crombag, Marie-Rose B S; van Werkhoven, Erik; Otten, Hans-Martin; Bergman, Andre M; Schellens, Jan H M; Huitema, Alwin D R; Beijnen, Jos H (John Wiley & Sons Inc., 2019-04-01)

The incidence of neutropenia in metastatic castration-resistant prostate cancer (mCRPC) patients treated with docetaxel has been reported to be lower compared to patients with other solid tumors treated with a similar dose. ...
Insights in work rehabilitation after minimally invasive esophagectomy

Geeraerts, Melissa; Silva Corten, Luis Carlos; van Det, Marc; Luyer, Misha; Nieuwenhuijzen, Grard; Vermeer, Marloes; Ruurda, Jelle; van Hillegersberg, Richard; Kouwenhoven, Ewout (Springer New York, 2019-10)

Background: Little is known about work rehabilitation after totally minimally invasive esophagectomy. The goal of this study was to further objectify the postoperative work rehabilitation. Not only duration of sick leave, ...
Improved repeatability of dynamic contrast-enhanced MRI using the complex MRI signal to derive arterial input functions: a test-retest study in prostate cancer patients

Klawer, Edzo M E; van Houdt, Petra J; Simonis, Frank F J; van den Berg, Cornelis A T; Pos, Floris J; Heijmink, Stijn W T P J; Isebaert, Sofie; Haustermans, Karin; van der Heide, Uulke A (John Wiley & Sons Inc., 2019-05)

PURPOSE: The arterial input function (AIF) is a major source of uncertainty in tracer kinetic (TK) analysis of dynamic contrast-enhanced (DCE)-MRI data. The aim of this study was to investigate the repeatability of AIFs ...
Innate immune recovery predicts CD4+ T-cell reconstitution after Hematopoietic Cell Transplantation

de Koning, Coco; Langenhorst, Jurgen; van Kesteren, Charlotte; Lindemans, Caroline A; Huitema, Alwin D R; Nierkens, Stefan; Boelens, Jaap Jan (Elsevier, 2019-04-01)

Innate immune cells are the first to recover after allogeneic hematopoietic cell transplantation (HCT). Nevertheless, reports of innate immune cell recovery and their relation to adaptive recovery after HCT are largely ...
Impact of CYP3A4*22 on Pazopanib Pharmacokinetics in Cancer Patients

Bins, Sander; Huitema, Alwin D R; Laven, Pim; Bouazzaoui, Samira El; Yu, Huixin; van Erp, Nielka; van Herpen, Carla; Hamberg, Paul; Gelderblom, Hans; Steeghs, Neeltje; Sleijfer, Stefan; van Schaik, Ron H N; Mathijssen, Ron H J; Koolen, Stijn L W (Adis, 2019-05-01)

Background and Objective: As pazopanib plasma trough concentrations are correlated with treatment outcome, we explored whether single nucleotide polymorphisms in the elimination pathway of pazopanib affect systemic pazopanib ...
Independent development of lymphoid and histiocytic malignancies from a shared early precursor

Waanders, E.; Hebeda, K. M.; Kamping, E. J.; Groenen, P. J T A; Simons, A.; Hoischen, A.; Jongmans, M. C J; Hoogerbrugge, P. M.; Van Leeuwen, F. N.; Kuiper, R. P.; Te Loo, D. M W M (Springer Nature, 2016-04-01)
Uncompromised MRI of knee cartilage while incorporating sensitive sodium MRI

Brinkhof, S.; Ali Haghnejad, A.; Ito, K.; Markenroth Bloch, K.; Klomp, D. W.J. (John Wiley & Sons Inc., 2019-11-01)

Sodium imaging is able to assess changes in ion content, linked to glycosaminoglycan content, which is important to guide orthopeadic procedures such as articular cartilage repair. Sodium imaging is ideally performed using ...
Methodological consensus on clinical proton MRS of the brain: Review and recommendations

Wilson, Martin; Andronesi, Ovidiu; Barker, Peter B.; Bartha, Robert; Bizzi, Alberto; Bolan, Patrick J.; Brindle, Kevin M.; Choi, In Young; Cudalbu, Cristina; Dydak, Ulrike; Emir, Uzay E.; Gonzalez, Ramon G.; Gruber, Stephan; Gruetter, Rolf; Gupta, Rakesh K.; Heerschap, Arend; Henning, Anke; Hetherington, Hoby P.; Huppi, Petra S.; Hurd, Ralph E.; Kantarci, Kejal; Kauppinen, Risto A.; Klomp, Dennis W.J.; Kreis, Roland; Kruiskamp, Marijn J.; Leach, Martin O.; Lin, Alexander P.; Luijten, Peter R.; Marjańska, Małgorzata; Maudsley, Andrew A.; Meyerhoff, Dieter J.; Mountford, Carolyn E.; Mullins, Paul G.; Murdoch, James B.; Nelson, Sarah J.; Noeske, Ralph; Öz, Gülin; Pan, Julie W.; Peet, Andrew C.; Poptani, Harish; Posse, Stefan; Ratai, Eva Maria; Salibi, Nouha; Scheenen, Tom W.J.; Smith, Ian C.P.; Soher, Brian J.; Tkáč, Ivan; Vigneron, Daniel B.; Howe, Franklyn A. (John Wiley & Sons Inc., 2019-08-01)

Proton MRS ( 1 H MRS) provides noninvasive, quantitative metabolite profiles of tissue and has been shown to aid the clinical management of several brain diseases. Although most modern clinical MR scanners support MRS ...
Low SAR P-31 (multi-echo) spectroscopic imaging using an integrated whole-body transmit coil at 7T

van Houtum, Q.; Welting, D.; Gosselink, W. J.M.; Klomp, D. W.J.; Arteaga de Castro, C. S.; van der Kemp, W. J.M. (John Wiley & Sons Inc., 2019-12-01)

Phosphorus (31P) MRSI provides opportunities to monitor potential biomarkers. However, current applications of 31P MRS are generally restricted to relatively small volumes as small coils are used. Conventional surface coils ...
Opening a new window on MR-based Electrical Properties Tomography with deep learning

Mandija, Stefano; Meliadò, Ettore F.; Huttinga, Niek R.F.; Luijten, Peter R.; van den Berg, Cornelis A.T. (Nature Publishing Group, 2019-06-20)

In the radiofrequency (RF) range, the electrical properties of tissues (EPs: conductivity and permittivity) are modulated by the ionic and water content, which change for pathological conditions. Information on tissues EPs ...
Contradiction between amide-CEST signal and pH in breast cancer explained with metabolic MRI

Krikken, Erwin; van der Kemp, Wybe J.M.; Khlebnikov, Vitaliy; van Dalen, Thijs; Los, Maartje; van Laarhoven, Hanneke W.M.; Luijten, Peter R.; van den Bosch, Maurice A.A.J.; Klomp, Dennis W.J.; Wijnen, Jannie P. (John Wiley & Sons Inc., 2019-08-01)

Purpose: Metabolic MRI is a noninvasive technique that can give new insights into understanding cancer metabolism and finding biomarkers to evaluate or monitor treatment plans. Using this technique, a previous study has ...
Eliminating biasing signals in lung cancer images for prognosis predictions with deep learning

van Amsterdam, W. A. C.; Verhoeff, J. J. C.; de Jong, P. A.; Leiner, T.; Eijkemans, M. J. C. (Nature Publishing Group, 2019-12-10)

Deep learning has shown remarkable results for image analysis and is expected to aid individual treatment decisions in health care. Treatment recommendations are predictions with an inherently causal interpretation. To use ...

Now showing items 22981-23000 of 40729