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UMC Repository: Recent submissions

  • Membraneless organelles in cell biology 
    Rabouille, Catherine (Blackwell Munksgaard, 2019-12)
  • The hepatic WASH complex is required for efficient plasma LDL and HDL cholesterol clearance 
    Wijers, Melinde; Zanoni, Paolo; Liv, Nalan; Vos, Dyonne Y; Jäckstein, Michelle Y; Smit, Marieke; Wilbrink, Sanne; Wolters, Justina C; van der Veen, Ydwine T; Huijkman, Nicolette; Dekker, Daphne; Kloosterhuis, Niels; van Dijk, Theo H; Billadeau, Daniel D; Kuipers, Folkert; Klumperman, Judith; von Eckardstein, Arnold; Kuivenhoven, Jan Albert; van de Sluis, Bart (American Society for Clinical Investigation, 2019-06-06)
    The evolutionary conserved Wiskott-Aldrich syndrome protein and SCAR homolog (WASH) complex is one of the crucial multiprotein complexes that facilitates endosomal recycling of transmembrane proteins. Defects in WASH ...
  • The ubiquitin-conjugating enzyme UBE2QL1 coordinates lysophagy in response to endolysosomal damage 
    Koerver, Lisa; Papadopoulos, Chrisovalantis; Liu, Bin; Kravic, Bojana; Rota, Giulia; Brecht, Lukas; Veenendaal, Tineke; Polajnar, Mira; Bluemke, Anika; Ehrmann, Michael; Klumperman, Judith; Jäättelä, Marja; Behrends, Christian; Meyer, Hemmo (Springer Science and Business Media Deutschland GmbH, 2019-10-04)
    The autophagic clearance of damaged lysosomes by lysophagy involves extensive modification of the organelle with ubiquitin, but the underlying ubiquitination machinery is still poorly characterized. Here, we use an siRNA ...
  • Bruggenbouwers tussen wetenschap en praktijk 
    Bartelink, Marie Louise; Baggen, Yvette; Stevens, Diede; Smalbrugge, Martin; Scherpbier, Nynke; Damoiseaux, Roger; de Groot, Esther (Bohn Stafleu van Loghum, 2019-11-01)
    Inleiding Arts-onderzoekers zijn praktiserende dokters die ook een academische rol hebben. Zij zijn bij uitstek degenen die wetenschap en praktijk kunnen verbinden. Wij onderzochten hoe arts-onderzoekers binnen de ...
  • Three-dimensional analysis of single molecule FISH in human colon organoids 
    Omerzu, Manja; Fenderico, Nicola; De Barbanson, Buys; Sprangers, Joep; De Ridder, Jeroen; Maurice, Madelon M. (Company of Biologists Ltd, 2019-08-09)
    The culturing of mini-organs (organoids) in three-dimensions (3D) presents a simple and powerful tool to investigate the principles underlying human organ development and tissue self-organization in both healthy and diseased ...
  • EAU-EANM-ESTRO-ESUR-SIOG Prostate Cancer Guideline Panel Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer from an International Collaborative Study (DETECTIVE Study) 
    Lam, Thomas B L; MacLennan, Steven; Willemse, Peter-Paul M; Mason, Malcolm D; Plass, Karin; Shepherd, Robert; Baanders, Ruud; Bangma, Chris H; Bjartell, Anders; Bossi, Alberto; Briers, Erik; Briganti, Alberto; Buddingh, Karel T; Catto, James W F; Colecchia, Maurizio; Cox, Brett W; Cumberbatch, Marcus G; Davies, Jeff; Davis, Niall F; De Santis, Maria; Dell'Oglio, Paolo; Deschamps, André; Donaldson, James F; Egawa, Shin; Fankhauser, Christian D; Fanti, Stefano; Fossati, Nicola; Gandaglia, Giorgio; Gillessen, Silke; Grivas, Nikolaos; Gross, Tobias; Grummet, Jeremy P; Henry, Ann M; Ingels, Alexandre; Irani, Jacques; Lardas, Michael; Liew, Matthew; Lin, Daniel W; Moris, Lisa; Omar, Muhammad Imran; Pang, Karl H; Paterson, Catherine C; Renard-Penna, Raphaële; Ribal, Maria J; Roobol, Monique J; Rouprêt, Morgan; Rouvière, Olivier; Sancho Pardo, Gemma; Richenberg, Jonathan; Schoots, Ivo G; Sedelaar, J P Michiel; Stricker, Phillip; Tilki, Derya; Vahr Lauridsen, Susanne; van den Bergh, Roderick C N; Van den Broeck, Thomas; van der Kwast, Theodorus H; van der Poel, Henk G; van Leenders, Geert J L H; Varma, Murali; Violette, Philippe D; Wallis, Christopher J D; Wiegel, Thomas; Wilkinson, Karen; Zattoni, Fabio; N'Dow, James M O; Van Poppel, Hendrik; Cornford, Philip; Mottet, Nicolas (Elsevier, 2019-12)
    BACKGROUND: There is uncertainty in deferred active treatment (DAT) programmes, regarding patient selection, follow-up and monitoring, reclassification, and which outcome measures should be prioritised. OBJECTIVE: To develop ...
  • Targeted Therapy in Advanced Melanoma With Rare BRAF Mutations 
    Menzer, Christian; Menzies, Alexander M; Carlino, Matteo S; Reijers, Irene; Groen, Emma J; Eigentler, Thomas; de Groot, Jan Willem B; van der Veldt, Astrid A M; Johnson, Douglas B; Meiss, Frank; Schlaak, Max; Schilling, Bastian; Westgeest, Hans M; Gutzmer, Ralf; Pföhler, Claudia; Meier, Friedegund; Zimmer, Lisa; Suijkerbuijk, Karijn P M; Haalck, Thomas; Thoms, Kai-Martin; Leichsenring, Jonas; Menzer, Alexander; Kopp-Schneider, Annette; Long, Georgina V; Kefford, Richard; Enk, Alexander; Blank, Christian U; Hassel, Jessica C (Lippincott Williams & Wilkins, 2019-11-20)
    PURPOSE: BRAF/MEK inhibition is a standard of care for patients with BRAF V600E/K-mutated metastatic melanoma. For patients with less frequent BRAF mutations, however, efficacy data are limited. METHODS: In the current ...
  • Association Between Use of Primary Prevention Implantable Cardioverter-Defibrillators and Mortality in Patients with Heart Failure: A Prospective Propensity-Score Matched Analysis from the Swedish Heart Failure Registry 
    Schrage, Benedikt; Uijl, Alicia; Benson, Lina; Westermann, Dirk; Ståhlberg, Marcus; Stolfo, Davide; Dahlström, Ulf; Linde, Cecilia M; Braunschweig, Frieder; Savarese, Gianluigi (Lippincott Williams & Wilkins, 2019-11-05)
    BACKGROUND: Most randomized trials on implantable cardioverter-defibrillator (ICD) use for primary prevention of sudden cardiac death in heart failure with reduced ejection fraction enrolled patients >20 years ago. We ...
  • Agreement between skeletal muscle mass measurements using computed tomography imaging and magnetic resonance imaging in head and neck cancer patients 
    Chargi, N; Ansari, E; Huiskamp, L F J; Bol, G; de Bree, R (Elsevier Limited, 2019-12)
  • Surgical consensus guidelines on sentinel node biopsy (SNB) in patients with oral cancer 
    Schilling, Clare; Stoeckli, Sando J; Vigili, Maurizio G; de Bree, Remco; Lai, Stephen Y; Alvarez, Julio; Christensen, Anders; Cognetti, David M; D'Cruz, Anil K; Frerich, Bernhard; Garrel, Renaud; Kohno, Naoyuki; Klop, Willem Martin; Kerawala, Cyrus; Lawson, Georges; McMahon, Jeremy; Sassoon, Isabel; Shaw, Richard J; Tvedskov, Jesper F; von Buchwald, Christian; McGurk, Mark (John Wiley & Sons Inc., 2019-08)
    BACKGROUND: The eighth international symposium for sentinel node biopsy (SNB) in head and neck cancer was held in 2018. This consensus conference aimed to deliver current multidisciplinary guidelines. This document focuses ...
  • Stepped care targeting psychological distress in head and neck cancer and lung cancer patients: which groups specifically benefit? Secondary analyses of a randomized controlled trial 
    Jansen, Femke; Lissenberg-Witte, Birgit I; Krebber, Anna M H; Cuijpers, Pim; de Bree, Remco; Becker-Commissaris, Annemarie; Smit, Egbert F; van Straten, Annemieke; Eeckhout, Guus M; Beekman, Aartjan T F; Leemans, C René; Verdonck-de Leeuw, Irma M (Springer-Verlag, 2019-12)
    PURPOSE: Stepped care (SC), consisting of watchful waiting, guided self-help, problem-solving therapy, and psychotherapy/medication is, compared to care-as-usual (CAU), effective in improving psychological distress. This ...
  • Treatment and survival of resected and unresected distal cholangiocarcinoma: a nationwide study 
    Dutch Pancreatic Cancer Group (Informa Healthcare, 2019-07)
    Background: Population-based data on distal cholangiocarcinoma (DCC) from the Western world are not available, albeit essential to identify areas for improvement. This study investigated the incidence, treatment and outcomes, ...
  • External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort 
    Lamain-de Ruiter, Marije; Kwee, Anneke; Naaktgeboren, Christiana A; Louhanepessy, Rebecca D; De Groot, Inge; Evers, Inge M; Groenendaal, Floris; Hering, Yolanda R; Huisjes, Anjoke J M; Kirpestein, Cornel; Monincx, Wilma M; Schielen, Peter C J I; Van 't Zelfde, Annewil; Van Oirschot, Charlotte M; Vankan-Buitelaar, Simone A; Vonk, Mariska A A W; Wiegers, Therese A; Zwart, Joost J; Moons, Karel G M; Franx, Arie; Koster, Maria P H (Informa Healthcare, 2019-03-20)
    Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Methods: Women <14 weeks of pregnancy were recruited in the ...
  • Updated Survival Analysis of the Randomized Phase III Trial of S-1 Versus Capecitabine in the First-Line Treatment of Metastatic Colorectal Cancer by the Dutch Colorectal Cancer Group 
    Kwakman, Johannes J M; van Werkhoven, Erik; Simkens, Lieke H J; van Rooijen, Johan M; van de Wouw, Yes A J; Tije, Albert J Ten; Creemers, Geert-Jan M; Hendriks, Mathijs P; Los, Maartje; van Alphen, Robbert J; Polée, Marco B; Muller, Erik W; van der Velden, Ankie M T; van Voorthuizen, Theo; Koopman, Miriam; Mol, Linda; Punt, Cornelis J A (Elsevier, 2019-06)
  • Randomized, Open-Label, Crossover Studies Evaluating the Effect of Food and Liquid Formulation on the Pharmacokinetics of the Novel Focal Adhesion Kinase (FAK) Inhibitor BI 853520 
    Verheijen, Remy B; van der Biessen, Diane A J; Hotte, Sebastien J; Siu, Lillian L; Spreafico, Anna; de Jonge, Maja J A; Pronk, Linda C; De Vos, Filip Y F L; Schnell, David; Hirte, Hal W; Steeghs, Neeltje; Lolkema, Martijn P (Springer Paris, 2019-02)
    Background: BI 853520 is a potent inhibitor of focal adhesion kinase and is currently under clinical development for the treatment of non-hematological malignancies. Objective: The objective of this study was to evaluate ...
  • ASO Author Reflections: The Role of Robotic Surgery in Liver Resection 
    Nota, Carolijn L; Hagendoorn, Jeroen; Fong, Yuman (Springer New York, 2019-02-15)
  • Clinical prediction of thrombectomy eligibility: A systematic review and 4-item decision tree 
    Koster, Gaia T.; Nguyen, T. Truc My; van Zwet, Erik W.; Garcia, Bjarty L.; Rowling, Hannah R.; Bosch, J.; Schonewille, Wouter J.; Velthuis, Birgitta K.; van den Wijngaard, Ido R.; den Hertog, Heleen M.; Roos, Yvo B.W.E.M.; van Walderveen, Marianne A.A.; Wermer, Marieke J.H.; Kruyt, Nyika D. (SAGE Publications Ltd, 2019-07-01)
    BACKGROUND: A clinical large anterior vessel occlusion (LAVO)-prediction scale could reduce treatment delays by allocating intra-arterial thrombectomy (IAT)-eligible patients directly to a comprehensive stroke center. AIM: ...
  • Outcomes and Risk Score for Distal Pancreatectomy with Celiac Axis Resection (DP-CAR): An International Multicenter Analysis 
    E-AHPBA DP-CAR study group (Springer New York, 2019-03)
    BACKGROUND: Distal pancreatectomy with celiac axis resection (DP-CAR) is a treatment option for selected patients with pancreatic cancer involving the celiac axis. A recent multicenter European study reported a 90-day ...
  • Nivolumab for Relapsed/Refractory Diffuse Large B-Cell Lymphoma in Patients Ineligible for or Having Failed Autologous Transplantation: A Single-Arm, Phase II Study 
    Ansell, Stephen M; Minnema, Monique C; Johnson, Peter; Timmerman, John M; Armand, Philippe; Shipp, Margaret A; Rodig, Scott J; Ligon, Azra H; Roemer, Margaretha G M; Reddy, Nishitha; Cohen, Jonathon B; Assouline, Sarit; Poon, Michelle; Sharma, Manish; Kato, Kazunobu; Samakoglu, Selda; Sumbul, Anne; Grigg, Andrew (Lippincott Williams & Wilkins, 2019-02-20)
    PURPOSE: Treatment options are limited for patients with relapsed/refractory diffuse large B-cell lymphoma (DLBCL). Tumor cells can exploit the programmed death-1 checkpoint pathway to evade immune surveillance. In the ...
  • Superiority of Step-up Approach vs Open Necrosectomy in Long-term Follow up of Patients With Necrotizing Pancreatitis 
    Dutch Pancreatitis Study Group (W.B. Saunders, 2019-03)
    Background & Aims: In a 2010 randomized trial (the PANTER trial), a surgical step-up approach for infected necrotizing pancreatitis was found to reduce the composite endpoint of death or major complications compared with ...