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UMC Repository: Recent submissions

  • Enabling single-site laparoscopy: the SPORT platform 
    Seeliger, Barbara; Diana, Michele; Ruurda, Jelle P; Konstantinidis, Konstantinos M; Marescaux, Jacques; Swanström, Lee L (Springer New York, 2019-11)
    BACKGROUND: The Single Port Orifice Robotic Technology (SPORT) Surgical System by Titan Medical Inc. is designed to overcome the inherent challenges of minimally invasive single-access procedures. The aim of this preclinical ...
  • Promoting shared decision making in advanced cancer: Development and piloting of a patient communication aid 
    Henselmans, Inge; Brugel, Sabrina D.; de Haes, Hanneke C.J.M.; Wolvetang, Kim J.A.; de Vries, Laura M.; Pieterse, Arwen H.; Baas-Thijssen, Monique C.M.; de Vos, Filip Y.F.; van Laarhoven, Hanneke W.M.; Smets, Ellen M.A. (Elsevier Ireland Ltd, 2019-05)
    Objective: To learn how to configure a patient communication aid (PCA) to facilitate shared decision-making (SDM) about treatment for advanced cancer. Methods: The PCA consists of education about SDM, a question prompt ...
  • An assisted structured reflection on life events and life goals in advanced cancer patients: Outcomes of a randomized controlled trial (Life InSight Application (LISA) study) 
    Kruizinga, Renske; Scherer-Rath, Michael; Schilderman, Johannes Bam; Hartog, Iris D; Van Der Loos, Jacoba Pm; Kotzé, Hantie P; Westermann, Anneke M; Klümpen, Heinz-Josef; Kortekaas, Francesco; Grootscholten, Cecile; Bossink, Frans; Schrama, Jolanda; Van De Vrande, Willem; Schrama, Natascha Awp; Blokland, Willem; De Vos, Filip Yfl; Kuin, Annemieke; Meijer, Wim G; Van Oijen, Martijn Gh; Sprangers, Mirjam Ag; Van Laarhoven, Hanneke Wm (SAGE Publications Ltd, 2019-02)
    BACKGROUND:: Diagnosis and treatment of incurable cancer as a life-changing experience evokes difficult existential questions. AIM:: A structured reflection could improve patients' quality of life and spiritual well-being. ...
  • The effect of helminths on granulocyte activation: a cluster-randomized placebo-controlled trial in Indonesia 
    de Ruiter, Karin; Tahapary, Dicky L; Sartono, Erliyani; Nutman, Thomas B; Smit, Johannes W A; Koenderman, Leo; Supali, Taniawati; Yazdanbakhsh, Maria (Oxford University Press, 2019-04-16)
    Background: Eosinophils are a prominent cell type in the host response to helminths, and some evidence suggests that neutrophils might also play a role. However, little is known about the activation status of these ...
  • Falsely decreased ferritin concentrations in two patients with haemophagocytic lymphohistiocytosis: A case report 
    Roozen, Geert; Revet, Ingrid; Raymakers, Reinier; Kemperman, Hans (SAGE Publications Ltd, 2019-01)
    The high-dose hook effect, or prozone effect, can lead to negative or falsely lowered plasma ferritin results. Here, cases of a 16-year-old boy and a 70-year-old woman with haemophagocytic lymphohystiocytosis with extremely ...
  • Feasibility and efficacy of addition of individualized dose lenalidomide to chlorambucil and rituximab as first-line treatment in elderly and FCR-unfit patients with advanced chronic lymphocytic leukemia 
    Kater, Arnon P; van Oers, Marinus H J; van Norden, Yvette; van der Straten, Lina; Driessen, Julia; Posthuma, Ward F M; Schipperus, Martinus; Chamuleau, Martine E D; Nijland, Marcel; Doorduijn, Jeanette K; Van Gelder, Michel; Hoogendoorn, Mels; De Croon, Francien; Wittebol, Shulamiet; Kerst, J Martijn; Marijt, Erik W A; Raymakers, Reinier A P; Schaafsma, Martijn R; Dobber, Johan A; Kersting, Sabina A; Levin, Mark-David; HOVON CLL study group (Ferrata Storti Foundation, 2019-01)
    Lenalidomide has been proven to be effective but with a distinct and difficult to manage toxicity profile in the context of chronic lymphocytic leukemia, potentially hampering combination treatment with this drug. We ...
  • Primary lung cancer in patients with previous malignancies: a nationwide study 
    Mets, Onno M; Schaefer-Prokop, Cornelia M; de Jong, Pim A (BMJ Publishing Group, 2019-05)
    Overall survival of patients with cancer continues to increase and so they receive more frequent CT imaging, making oncological patients a growing population that effectively receives lung cancer screening in the course ...
  • Value of MRI in medicine: More than just another test? 
    van Beek, Edwin J R; Kuhl, Christiane; Anzai, Yoshimi; Desmond, Patricia; Ehman, Richard L; Gong, Qiyong; Gold, Garry; Gulani, Vikas; Hall-Craggs, Margaret; Leiner, Tim; Lim, C C Tschoyoson; Pipe, James G; Reeder, Scott; Reinhold, Caroline; Smits, Marion; Sodickson, Daniel K; Tempany, Clare; Vargas, H Alberto; Wang, Meiyun (John Wiley & Sons Inc., 2019-06)
    There is increasing scrutiny from healthcare organizations towards the utility and associated costs of imaging. MRI has traditionally been used as a high-end modality, and although shown extremely important for many types ...
  • Surgical margins in head and neck cancer: Intra- and postoperative considerations 
    Thomas Robbins, K; Triantafyllou, Asterios; Suárez, Carlos; López, Fernando; Hunt, Jennifer L; Strojan, Primož; Williams, Michelle D; Braakhuis, Boudewijn J M; de Bree, Remco; Hinni, Michael L; Kowalski, Luiz P; Rinaldo, Alessandra; Rodrigo, Juan P; Vander Poorten, Vincent; Nixon, Iain J; Takes, Robert P; Silver, Carl E; Ferlito, Alfio (Elsevier Ireland Ltd, 2019-02)
    OBJECTIVE: To provide a perspective on the significance of recent reports for optimizing cancer free surgical margins that have challenged standard practices. METHODS: We conducted a review of the recent literature (2012-2018) ...
  • Training for Medical Oncologists on Shared Decision-Making About Palliative Chemotherapy: A Randomized Controlled Trial 
    Henselmans, Inge; van Laarhoven, Hanneke W M; de Haes, Hanneke C J M; Tokat, Meltem; Engelhardt, Ellen G; van Maarschalkerweerd, Pomme E A; Kunneman, Marleen; Ottevanger, Petronella B; Dohmen, Serge E; Creemers, Geert-Jan; Sommeijer, Dirkje W; de Vos, Filip Y F L; Smets, Ellen M A (AlphaMed Press, 2019-02)
    BACKGROUND: Systemic treatment for advanced cancer offers uncertain and sometimes limited benefit, while the burden can be high. This study examines the effect of shared decision-making (SDM) training for medical oncologists ...
  • Generative Adversarial Network for Segmentation of Motion Affected Neonatal Brain MRI 
    Khalili, N.; Turk, E.; Zreik, M.; Viergever, M. A.; Benders, M. J.N.L.; Išgum, I. (Springer, 2019-01-01)
    Automatic neonatal brain tissue segmentation in preterm born infants is a prerequisite for evaluation of brain development. However, automatic segmentation is often hampered by motion artifacts caused by infant head movements ...
  • Polymeric siRNA gene delivery- transfection efficiency versus cytotoxicity 
    Sluijter, Joost P.G.; Kargaard, A; Klumperman, B. (Elsevier, 2019-12-28)
    Within the field of gene therapy, there is a considerable need for the development of non-viral vectors that are able to compete with the efficiency obtained by viral vectors, while maintaining a good toxicity profile and ...
  • ASO Author Reflections: The Changing Role of Gene Expression Profiling in ER+/HER2- Breast Cancer 
    van Steenhoven, Julia E C; van Dalen, T (Springer New York, 2019-12)
  • A National Cohort Study Evaluating the Association Between Short-term Outcomes and Long-term Survival After Esophageal and Gastric Cancer Surgery 
    van der Werf, Leonie R; Wijnhoven, Bas P L; Fransen, Laura F C; van Sandick, Johanna W; Nieuwenhuijzen, Grard A P; Busweiler, Linde A D; van Hillegersberg, Richard; Wouters, Michel W J M; Luyer, Misha D P; van Berge Henegouwen, Mark I (Lippincott Williams & Wilkins, 2019-11)
    Objective:The aim of this study was to investigate the association between short-term outcome indicators and long-term survival after esophagogastric resections.Summary Background Data:Short-term outcome indicators are ...
  • Locally Advanced Pancreatic Cancer: Work-Up, Staging, and Local Intervention Strategies 
    Dutch Pancreatic Cancer Group and International Collaborative Group on Locally Advanced Pancreatic Cancer (Multidisciplinary Digital Publishing Institute (MDPI), 2019-07-12)
    Locally advanced pancreatic cancer (LAPC) has several definitions but essentially is a nonmetastasized pancreatic cancer, in which upfront resection is considered not beneficial due to extensive vascular involvement and ...
  • Treatment of disrupted and disconnected pancreatic duct in necrotizing pancreatitis: A systematic review and meta-analysis 
    Dutch Pancreatitis Study Group (Elsevier, 2019-10)
    BACKGROUND: Necrotizing pancreatitis may lead to loss of integrity of the pancreatic duct, resulting in leakage of pancreatic fluid. Pancreatic duct disruption or disconnection is associated with a prolonged disease course ...
  • Long-term survival and complications following bladder-preserving brachytherapy in patients with cT1-T2 bladder cancer 
    Voskuilen, Charlotte S; Bosschieter, Judith; van Werkhoven, Erik; Hendricksen, Kees; Vis, André N; Witteveen, Thelma; Pieters, Bradley R; Burger, Max; Bex, Axel; van der Poel, Henk G; Moonen, Luc M; Horenblas, Simon; Nieuwenhuijzen, Jakko A; van Rhijn, Bas W G (Elsevier Ireland Ltd, 2019-12)
    BACKGROUND AND PURPOSE: Radical cystectomy (RC) is considered standard treatment for muscle-invasive bladder cancer (BC) and high-risk non-muscle invasive BC. In selected cases, bladder-sparing treatment using brachytherapy ...
  • Targeted Intervention to Improve the Quality of Head and Neck Radiation Therapy Treatment Planning in the Netherlands: Short and Long-Term Impact 
    Verbakel, Wilko F A R; Doornaert, Patricia A H; Raaijmakers, Cornelis P J; Bos, Luc J; Essers, Marion; van de Kamer, Jeroen B; Dahele, Max; Terhaard, Chris H J; Kaanders, Johannes H A M (Elsevier, 2019-11-01)
    PURPOSE: To benchmark and improve, through means of a targeted intervention, the quality of intensity modulated radiation therapy treatment planning for locally advanced head and neck cancer (HNC) in the Netherlands. The ...
  • Genome-wide cell-free DNA fragmentation in patients with cancer 
    Cristiano, Stephen; Leal, Alessandro; Phallen, Jillian; Fiksel, Jacob; Adleff, Vilmos; Bruhm, Daniel C; Jensen, Sarah Østrup; Medina, Jamie E; Hruban, Carolyn; White, James R; Palsgrove, Doreen N; Niknafs, Noushin; Anagnostou, Valsamo; Forde, Patrick; Naidoo, Jarushka; Marrone, Kristen; Brahmer, Julie; Woodward, Brian D; Husain, Hatim; van Rooijen, Karlijn L; Ørntoft, Mai-Britt Worm; Madsen, Anders Husted; van de Velde, Cornelis J H; Verheij, Marcel; Cats, Annemieke; Punt, Cornelis J A; Vink, Geraldine R; van Grieken, Nicole C T; Koopman, Miriam; Fijneman, Remond J A; Johansen, Julia S; Nielsen, Hans Jørgen; Meijer, Gerrit A; Andersen, Claus Lindbjerg; Scharpf, Robert B; Velculescu, Victor E (Nature Research, 2019-06)
    Cell-free DNA in the blood provides a non-invasive diagnostic avenue for patients with cancer1. However, characteristics of the origins and molecular features of cell-free DNA are poorly understood. Here we developed an ...
  • Evaluation of Continuous Tumor-Size-Based End Points as Surrogates for Overall Survival in Randomized Clinical Trials in Metastatic Colorectal Cancer 
    Aide et Recherche en Cancerologie Digestive Group (American Medical Association, 2019-09-04)
    Importance: Tumor measurements can be used to estimate time to nadir and depth of nadir as potential surrogates for overall survival (OS). Objective: To assess time to nadir and depth of nadir as surrogates for OS in ...