External validation of prognostic models for preeclampsia in a Dutch multicenter prospective cohort
Lamain-de Ruiter, Marije; Kwee, Anneke; Naaktgeboren, Christiana A; Louhanepessy, Rebecca D; De Groot, Inge; Evers, Inge M; Groenendaal, Floris; Hering, Yolanda R; Huisjes, Anjoke J M; Kirpestein, Cornel; Monincx, Wilma M; Schielen, Peter C J I; Van 't Zelfde, Annewil; Van Oirschot, Charlotte M; Vankan-Buitelaar, Simone A; Vonk, Mariska A A W; Wiegers, Therese A; Zwart, Joost J; Moons, Karel G M; Franx, Arie; Koster, Maria P H
(2019) Hypertension in Pregnancy, volume 38, issue 2, pp. 78 - 88
(Article)
Abstract
Objective: To perform an external validation of all published prognostic models for first-trimester prediction of the risk of developing preeclampsia (PE). Methods: Women <14 weeks of pregnancy were recruited in the Netherlands. All systematically identified prognostic models for PE that contained predictors commonly available were eligible for external validation. Results:
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3,736 women were included; 87 (2.3%) developed PE. Calibration was poor due to overestimation. Discrimination of 9 models for LO-PE ranged from 0.58 to 0.71 and of 9 models for all PE from 0.55 to 0.75. Conclusion: Only a few easily applicable prognostic models for all PE showed discrimination above 0.70, which is considered an acceptable performance.
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Keywords: First trimester, external validation, preeclampsia, prognostic model, Models, Theoretical, Prognosis, Prospective Studies, Risk Assessment, Humans, Pre-Eclampsia/diagnosis, Pregnancy, Adult, Female, Obstetrics and Gynaecology, Internal Medicine, Journal Article, Multicenter Study, Validation Studies
ISSN: 1064-1955
Publisher: Informa Healthcare
(Peer reviewed)
