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Placental Histology After Minor Trauma in Pregnancy: A Pilot Study

van der Knoop, B. J.; van der Voorn, J. P.; Nikkels, P. G.J.; Zonnenberg, I. A.; van Weissenbruch, M. M.; Vermeulen, R. J.; de Vries, J. I.P. (SAGE Publications Inc., 2019-05)

OBJECTIVE: Trauma in pregnancy may cause placental abruption. Consequences of moderate placental injury on neurodevelopment are unknown. The aim was to evaluate placental histology after maternal trauma. METHODS: A prospective ...
Liver decompensation in HIV/Hepatitis B coinfection in the combination antiretroviral therapy era does not seem increased compared to hepatitis B mono-infection

Lieveld, Faydra I.; Smit, Colette; Richter, Clemens; van Erpecum, Karel J.; Spanier, Bernhard W.M.; Gisolf, Elisabeth H.; Vrolijk, Jan M.; Siersema, Peter D.; Hoepelman, Andy I.M.; Reiss, Peter; Arends, Joop E. (Wiley-Blackwell, 2019-03)

Background & Aims: HIV/hepatitis B virus (HBV) coinfected subjects are thought to have faster progression to end-stage liver disease (ESLD) than HBV mono-infected subjects. We assessed whether this remains in the current ...
Whole exome sequencing in the diagnostic workup of patients with a bleeding diathesis

Saes, Joline L; Simons, Annet; de Munnik, Sonja A; Nijziel, Marten R; Blijlevens, Nicole M A; Jongmans, Marjolijn C; van der Reijden, Bert A; Smit, Yolba; Brons, Paul P; van Heerde, Waander L; Schols, Saskia E M (Wiley-Blackwell, 2019-01)

INTRODUCTION: Bleeding assessment tools and laboratory phenotyping often remain inconclusive in patients with a haemorrhagic diathesis. AIM: To describe the phenotype and genetic profile of patients with a bleeding tendency. ...
Pulmonary Embolism After Endovascular Aortic Repair, a Retrospective Cohort Study

Grobben, Remco B.; Frima, Cynthia; Nathoe, Hendrik M.; Leiner, Tim; Kwakkel-van Erp, Johanna M.; van Klei, Wilton A.; Peelen, Linda M.; van Herwaarden, Joost A. (W.B. Saunders Ltd, 2019-02)

Objectives: Endovascular aortic repair (EVAR) is associated with an increased risk of pulmonary embolism, which is often clinically silent and therefore difficult to recognise. The aim was to investigate the incidence of ...
De novo truncating variants in the intronless IRF2BPL are responsible for developmental epileptic encephalopathy

Tran Mau-Them, F.; Guibaud, L.; Duplomb, L.; Keren, B.; Lindstrom, K.; Marey, I.; Mochel, F.; van den Boogaard, M. J.; Oegema, R.; Nava, C.; Masurel, A.; Jouan, T.; Jansen, F. E.; Au, M.; Chen, Agnes H.; Cho, M.; Duffourd, Y.; Lozier, E.; Konovalov, F.; Sharkov, A.; Korostelev, S.; Urteaga, B.; Dickson, P.; Vera, M.; Martínez-Agosto, Julián A.; Begemann, A.; Zweier, M.; Schmitt-Mechelke, T.; Rauch, A.; Philippe, C.; van Gassen, K.; Nelson, S.; Graham, J. M.; Friedman, J.; Faivre, L.; Lin, H. J.; Thauvin-Robinet, C.; Vitobello, A. (Lippincott Williams & Wilkins, 2019-04)

Purpose: Developmental and epileptic encephalopathies (DEEs) are severe clinical conditions characterized by stagnation or decline of cognitive and behavioral abilities preceded, accompanied or followed by seizures. Because ...
Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence

Arena, Andrea; Zimmer, Till S; van Scheppingen, Jackelien; Korotkov, Anatoly; Anink, Jasper J; Mühlebner, Angelika; Jansen, Floor E; van Hecke, Wim; Spliet, Wim G; van Rijen, Peter C; Vezzani, Annamaria; Baayen, Johannes C; Idema, Sander; Iyer, Anand M; Perluigi, Marzia; Mills, James D; van Vliet, Erwin A; Aronica, Eleonora (Wiley-Blackwell, 2019-05)

Oxidative stress (OS) occurs in brains of patients with epilepsy and coincides with brain inflammation, and both phenomena contribute to seizure generation in animal models. We investigated whether expression of OS and ...
IL4-10 fusion protein: a novel immunoregulatory drug combining activities of interleukin 4 and interleukin 10

Steen-Louws, C.; Hartgring, S. A.Y.; Popov-Celeketic, J.; Lopes, A. P.; de Smet, M. B.M.; Eijkelkamp, N.; Lafeber, F. P.J.G.; Hack, C. E.; van Roon, J. A.G. (Wiley-Blackwell, 2019-01)

The objective of this study was to test the capacity of a newly developed fusion protein of interleukin 4 (IL-4) and IL-10 [IL4-10 fusion protein (FP)] to shift multiple pro-inflammatory pathways towards immune regulation, ...
CFTR modulator theratyping: Current status, gaps and future directions

Clancy, John Paul; Cotton, Calvin U.; Donaldson, Scott H.; Solomon, George M.; VanDevanter, Donald R.; Boyle, Michael P.; Gentzsch, Martina; Nick, Jerry A.; Illek, Beate; Wallenburg, John C.; Sorscher, Eric J.; Amaral, Margarida D.; Beekman, Jeffrey M.; Naren, Anjaparavanda P.; Bridges, Robert J.; Thomas, Philip J.; Cutting, Garry; Rowe, Steven; Durmowicz, Anthony G.; Mense, Martin; Boeck, Kris D.; Skach, William; Penland, Christopher; Joseloff, Elizabeth; Bihler, Hermann; Mahoney, John; Borowitz, Drucy; Tuggle, Katherine L. (Elsevier, 2019-01)

Background: New drugs that improve the function of the cystic fibrosis transmembrane conductance regulator (CFTR) protein with discreet disease-causing variants have been successfully developed for cystic fibrosis (CF) ...
Cardiac events within one year after a subarachnoid haemorrhage: The predictive value of troponin elevation after aneurysm occlusion

Akkermans, Annemarie; Peelen, Linda M.; van Waes, Judith A.; Rinkel, Gabriël J.; van Klei, Wilton A. (Oxford University Press, 2019-03)

Background: Patients who survive after an aneurysmal subarachnoid haemorrhage (ASAH) have an increased incidence of cardiovascular events compared with the general population. We assessed whether troponin elevation after ...
General information for patients and carers considering haematopoietic stem cell transplantation (HSCT) for severe autoimmune diseases (ADs): A position statement from the EBMT Autoimmune Diseases Working Party (ADWP), the EBMT Nurses Group, the EBMT Patient, Family and Donor Committee and the Joint Accreditation Committee of ISCT and EBMT (JACIE)

Jessop, Helen; Farge, Dominique; Saccardi, Riccardo; Alexander, Tobias; Rovira, Montserrat; Sharrack, Basil; Greco, Raffaella; Wulffraat, Nico; Moore, John; Kazmi, Majid; Badoglio, Manuela; Adams, Gillian; Verhoeven, Bregje; Murray, John; Snowden, John A. (Springer Nature, 2019-07-01)

Over the last 20 years, haematopoietic stem cell transplantation (HSCT) has been used to treat patients with severe autoimmune and inflammatory diseases whose response to standard treatment options has been limited, resulting ...
Post-trial Access in Maternal Vaccine Trials

Van Roessel, I. M.A.A.; Mazur, N. I.; Shah, S. K.; Bont, L.; Van Der Graaf, R. (Thieme Medical Publishers, 2019-01-01)

Provisions for post-trial access (PTA) of the experimental intervention are required before the start of a clinical trial. Although there has been ample attention for PTA in the context of preventive vaccine research, ...
Barbara Ansell: A person ahead of her time

Woo, Pat; Wulffraat, Nico M.; Tyndall, Alan (Elsevier, 2019-06-01)
Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases: updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE)

for the European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and EBMT (JACIE) (Springer Nature, 2020-02)

These updated EBMT guidelines review the clinical evidence, registry activity and mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple sclerosis (MS) and other immune-mediated neurological ...
A genome-wide association study of sodium levels and drug metabolism in an epilepsy cohort treated with carbamazepine and oxcarbazepine

The EpiPGX Consortium (Wiley-Blackwell Publishing Ltd, 2019-03-01)

Objective: To ascertain the clinical and genetic factors contributing to carbamazepine- and oxcarbazepine-induced hyponatremia (COIH), and to carbamazepine (CBZ) metabolism, in a retrospectively collected, cross-sectional ...
Integrated clinical and omics approach to rare diseases: Novel genes and oligogenic inheritance in holoprosencephaly

Kim, Artem; Savary, Clara; Dubourg, Christèle; Carré, Wilfrid; Mouden, Charlotte; Hamdi-Rozé, Houda; Guyodo, Hélène; Douce, Jerome Le; Génin, Emmanuelle; Campion, Dominique; Dartigues, Jean François; Deleuze, Jean François; Lambert, Jean Charles; Redon, Richard; Ludwig, Thomas; Grenier-Boley, Benjamin; Letort, Sébastien; Lindenbaum, Pierre; Meyer, Vincent; Quenez, Olivier; Dina, Christian; Bellenguez, Céline; Charbonnier-Le Clézio, Camille; Giemza, Joanna; Chatel, Stéphanie; Férec, Claude; Le Marec, Hervé; Letenneur, Luc; Nicolas, Gaël; Rouault, Karen; Bacq, Delphine; Boland, Anne; Lechner, Doris; Wijmenga, Cisca; Swertz, Morris A.; Eline Slagboom, P.; Van Ommen, Gert Jan B.; Van Duijn, Cornelia M.; Boomsma, Dorret I.; De Bakker, Paul I.W.; Bovenberg, Jasper A.; Eline Slagboom, P.; De Craen, Anton J.M.; Beekman, Marian; Hofman, Albert; Willemsen, Gonneke; Wolffenbuttel, Bruce; Platteel, Mathieu; Du, Yuanping; Chen, Ruoyan; Cao, Hongzhi; Cao, Rui; Sun, Yushen; Sujie Cao, Jeremy; Van Dijk, Freerk; Neerincx, Pieter B.T.; Deelen, Patrick; Dijkstra, Martijn; Byelas, George; Kanterakis, Alexandros; Bot, Jan; Ye, Kai; Lameijer, Eric Wubbo; Vermaat, Martijn; Laros, Jeroen F.J.; Den Dunnen, Johan T.; De Knijff, Peter; Karssen, Lennart C.; Van Leeuwen, Elisa M.; Amin, Najaf; Koval, Vyacheslav; Rivadeneira, Fernando; Estrada, Karol; Hehir-Kwa, Jayne Y.; De Ligt, Joep; Abdellaoui, Abdel; Hottenga, Jouke Jan; Mathijs Kattenberg, V.; Van Enckevort, David; Mei, Hailiang; Santcroos, Mark; Van Schaik, Barbera D.C.; Handsaker, Robert E.; McCarroll, Steven A.; Eichler, Evan E.; Ko, Arthur; Sudmant, Peter; Francioli, Laurent C.; Kloosterman, Wigard P.; Nijman, Isaac J.; Guryev, Victor; Pasquier, Laurent; Flori, Elisabeth; Gonzales, Marie; Bénéteau, Claire; Boute, Odile; Attié-Bitach, Tania; Roume, Joelle; Goujon, Louise; Akloul, Linda; Odent, Sylvie; Watrin, Erwan; Dupé, Valérie; De Tayrac, Marie; David, Véronique (Oxford University Press, 2019-01-01)

Holoprosencephaly is a pathology of forebrain development characterized by high phenotypic heterogeneity. The disease presents with various clinical manifestations at the cerebral or facial levels. Several genes have been ...
Pathology image exchange: The Dutch digital pathology platform for exchange of whole-slide images for efficient teleconsultation, telerevision, and virtual expert panels

van Diest, Paul J.; Huisman, André; van Ekris, Jaap; Meijer, Jos; Willems, Stefan; Hofhuis, Hannelore; Verbeek, Xander; van der Wel, Myrtle; Vos, Shoko; Leguit, Roos; van den Brand, Michiel; Hebeda, Konnie; Grünberg, Katrien (Lippincott Williams & Wilkins, 2019-06-13)

Among the many uses of digital pathology, remote consultation, remote revision, and virtual slide panels may be the most important ones. This requires basic slide scanner infrastructure in participating laboratories to ...
A Multicenter Application of the 2018 Banff Classification for BK Polyomavirus-associated Nephropathy in Renal Transplantation

Bouatou, Yassine; Nguyen, Tri Q; Roelofs, Joris J T H; Bemelman, Frederike J; Michielsen, Laura; Goldschmeding, Roel; Kers, Jesper; Florquin, Sandrine (Lippincott Williams & Wilkins, 2019-12)

BACKGROUND: With current immunosuppressive regimens, BK polyomavirus-associated nephropathy (BKPyVAN) is still a matter of concern. Stratification of patients at risk for allograft loss is of uttermost importance to guide ...
Investigating the effectiveness and cost-effectiveness of FITNET-NHS (Fatigue in Teenagers on the interNET in the NHS) compared to activity management to treat paediatric chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME): Amendment to the published protocol

Anderson, Emma; Gaunt, Daisy; Metcalfe, Chris; Rai, Manmita; Hollingworth, William; Mills, Nicola; Beasant, Lucy; Parslow, Roxanne; Kessler, David; Macleod, John; Stallard, Paul; Knoop, Hans; Van De Putte, Elise; Nijhof, Sanne; Bleijenberg, Gijs; Crawley, Esther (BioMed Central, 2019-12-19)

The FITNET-NHS Trial is a UK, national, trial investigating whether an online cognitive behavioural therapy program (FITNET-NHS) for treating chronic fatigue syndrome/ME in adolescents is clinically effective and cost-effective ...
Parenteral hydroxocobalamin dose intensification in five patients with different types of early onset intracellular cobalamin defects: Clinical and biochemical responses

Scalais, Emmanuel; Osterheld, Elise; Geron, Christine; Pierron, Charlotte; Chafai, Ronit; Schlesser, Vincent; Borde, Patricia; Regal, Luc; Laeremans, Hilde; van Gassen, Koen L I; van den Heuvel, L Bert; De Meirleir, Linda (Springer Berlin, 2019-09)

Intracellular cobalamin metabolism (ICM) defects can be present as autosomal recessive or X-linked disorders. Parenteral hydroxocobalamin (P-OHCbl) is the mainstay of therapy, but the optimal dose has not been determined. ...
Recognizing a Non-classical Telomeropathy before Hematopoietic Stem Cell Transplantation in Pediatric Patients: A Case Series

Nederlof, Iris; Lindemans, Caroline A; Bierings, Marc B; Mohseny, Alexander B; Bresters, Dorine; Bartels, Marije (Wolters Kluwer Health, 2019-08)

Now showing items 22141-22160 of 40729