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UMC Repository: Recent submissions

  • Resection of hepatic and pulmonary metastasis from metastatic esophageal and gastric cancer: a nationwide study 
    Seesing, M F J; van der Veen, A; Brenkman, H J F; Stockmann, H B A C; Nieuwenhuijzen, G A P; Rosman, C; van den Wildenberg, F J H; van Berge Henegouwen, Mark I; van Duijvendijk, P; Wijnhoven, B P L; Stoot, J H M B; Lacle, M; Ruurda, J P; van Hillegersberg, R; Baas, P C; Boerma, D; de Steur, W O; de Waard, J W D; Heisterkamp, J; van Hillo, M; Kouwenhoven, E A; Liem, M S L; van der Peet, D L; Pierie, J P E N; Plukker, J T M; Roumen, R M H; Tetteroo, G W M; van Workum, F (Wiley-Blackwell, 2019-12-31)
    The standard of care for gastroesophageal cancer patients with hepatic or pulmonary metastases is best supportive care or palliative chemotherapy. Occasionally, patients can be selected for curative treatment instead. This ...
  • Resting State EEG Characteristics During Sedation With Midazolam or Propofol in Older Subjects 
    Numan, Tianne; van Dellen, Edwin; Vleggaar, Frank P; van Vlieberghe, Paul; Stam, Cornelis J; Slooter, Arjen J C (SAGE Publications Inc., 2019-11)
    BACKGROUND: Despite widespread application, little is known about the neurophysiological effects of light sedation with midazolam or propofol, particularly in older subjects. The aim of this study was to assess the effects ...
  • Predictive Value of Microdose Pharmacokinetics 
    van Nuland, Merel; Rosing, Hilde; Huitema, Alwin D R; Beijnen, Jos H (Adis, 2019-10)
    Phase 0 microdose trials are exploratory studies to early assess human pharmacokinetics of new chemical entities, while limiting drug exposure and risks for participants. The microdose concept is based on the assumption ...
  • Pancreatic acinar cell carcinoma is associated with BRCA2 germline mutations: a case report and literature review 
    Kryklyva, Valentyna; Haj Mohammad, Nadia; Morsink, Folkert H M; Ligtenberg, Marjolijn J L; Offerhaus, G Johan A; Nagtegaal, Iris D; de Leng, Wendy W J; Brosens, Lodewijk A A (Landes Bioscience, 2019-07-03)
    Acinar cell carcinoma (ACC) is a rare pancreatic neoplasm with dismal prognosis. Insights into the molecular basis of ACC can pave the way for the application of more effective, personalized therapies and detection of ...
  • Frequency of surgical resection after starting neoadjuvant chemoradiotherapy in patients with esophageal cancer: A population-based cohort study 
    Borggreve, Alicia S; van Rossum, Peter S N; Mook, Stella; Haj Mohammad, Nadia; van Hillegersberg, Richard; Ruurda, Jelle P (W.B. Saunders Ltd, 2019-10)
    BACKGROUND: Neoadjuvant chemoradiotherapy (nCRT) for resectable esophageal cancer is accompanied by the risk of treatment-related toxicity. The aim of this population-based cohort study was to provide insight in patients ...
  • Exhaustion of the bone marrow progenitor cell reserve is associated with major events in severe limb ischemia 
    Juventas Study Group (Springer Netherlands, 2019-08)
    Lower numbers of progenitor cells (PCs) in peripheral blood (PB) have been associated with cardiovascular events in high-risk populations. Therapies aiming to increase the numbers of PCs in circulation have been developed, ...
  • Recommendations for the clinical interpretation and reporting of copy number gains using gene panel NGS analysis in routine diagnostics 
    Eijkelenboom, Astrid; Tops, Bastiaan B J; van den Berg, Anke; van den Brule, Adrianus J C; Dinjens, Winand N M; Dubbink, Hendrikus J; Ter Elst, Arja; Geurts-Giele, Willemina R R; Groenen, Patricia J T A; Groenendijk, Floris H; Heideman, Daniëlle A M; Huibers, Manon M H; Huijsmans, Cornelis J J; Jeuken, Judith W M; van Kempen, Léon C; Korpershoek, Esther; Kroeze, Leonie I; de Leng, Wendy W J; van Noesel, Carel J M; Speel, Ernst-Jan M; Vogel, Maartje J; van Wezel, Tom; Nederlof, Petra M; Schuuring, Ed; Ligtenberg, Marjolijn J L (Springer-Verlag, 2019-06)
    Next-generation sequencing (NGS) panel analysis on DNA from formalin-fixed paraffin-embedded (FFPE) tissue is increasingly used to also identify actionable copy number gains (gene amplifications) in addition to sequence ...
  • Why is Pancreatic Cancer so Deadly?: The Pathologist's View 
    Hruban, Ralph H; Gaida, Matthias M; Thompson, Elizabeth; Hong, Seung-Mo; Nöe, Michaël; Brosens, Lodewijk A A; Jongepier, Martine; Offerhaus, G Johan A; Wood, Laura D (John Wiley & Sons Inc., 2019-06)
    The remarkable aggressiveness of pancreatic cancer has never been fully explained. Although clearly multifactorial, we postulate that venous invasion, a finding seen in most pancreatic cancers but not in most cancers of ...
  • A 5-day course of oral antibiotics followed by faecal transplantation to eradicate carriage of multidrug-resistant Enterobacteriaceae: a randomized clinical trial 
    the R-Gnosis WP3 study group (Elsevier, 2019-07)
    Objectives: Intestinal carriage with extended spectrum β-lactamase Enterobacteriaceae (ESBL-E) and carbapenemase-producing Enterobacteriaceae (CPE) can persist for months. We aimed to evaluate whether oral antibiotics ...
  • Submaximal heart rate seems inadequate to prescribe and monitor intensified training 
    Ten Haaf, Twan; Foster, Carl; Meeusen, Romain; Roelands, Bart; Piacentini, Maria Francesca; van Staveren, Selma; Koenderman, Leo; de Koning, Jos J (2019-09)
    The aim of this study is to investigate whether the change in (sub)maximal heart rate after intensified training is associated with the change in performance. Thirty subjects were recruited who performed cardiopulmonary ...
  • Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2 
    Pekkinen, Minna; Terhal, Paulien A; Botto, Lorenzo D; Henning, Petra; Mäkitie, Riikka E; Roschger, Paul; Jain, Amrita; Kol, Matthijs; Kjellberg, Matti A; Paschalis, Eleftherios P; van Gassen, Koen; Murray, Mary; Bayrak-Toydemir, Pinar; Magnusson, Maria K; Jans, Judith; Kausar, Mehran; Carey, John C; Somerharju, Pentti; Lerner, Ulf H; Vesa, Olkkonen M; Klaushofer, Klaus; Holthuis, Joost Cm; Mäkitie, Outi (American Society for Clinical Investigation, 2019-04-04)
    Mechanisms leading to osteoporosis are incompletely understood. Genetic disorders with skeletal fragility provide insight into metabolic pathways contributing to bone strength. We evaluated 6 families with rare skeletal ...
  • Large variability in clinical judgement and definitions of left bundle branch block to identify candidates for cardiac resynchronisation therapy 
    van Stipdonk, A M W; Vanbelle, S; Ter Horst, I A H; Luermans, J G; Meine, M; Maass, A H; Auricchio, A; Prinzen, F W; Vernooy, K (Elsevier Ireland Ltd, 2019-07-01)
    BACKGROUND: Left bundle branch block (LBBB) morphology is associated with improved outcome of cardiac resynchronisation therapy (CRT) and is an important criterion for patient selection. There are, however, multiple ...
  • Phase I Study of BI 853520, an Inhibitor of Focal Adhesion Kinase, in Patients with Advanced or Metastatic Nonhematologic Malignancies 
    de Jonge, Maja J A; Steeghs, Neeltje; Lolkema, Martijn P; Hotte, Sebastien J; Hirte, Hal W; van der Biessen, Diane A J; Abdul Razak, Albiruni R; De Vos, Filip Y F L; Verheijen, Remy B; Schnell, David; Pronk, Linda C; Jansen, Monique; Siu, Lillian L (Springer Paris, 2019-02)
    BACKGROUND: Overexpression/activation of focal adhesion kinase (FAK) in human malignancies has led to its evaluation as a therapeutic target. We report the first-in-human phase I study of BI 853520, a novel, potent, highly ...
  • Tamoxifen and pregnancy: an absolute contraindication? 
    Schuurman, T. N.; Witteveen, P. O.; van der Wall, E.; Passier, J. L.M.; Huitema, A. D.R.; Amant, F.; Lok, C. A.R. (Springer New York, 2019-05)
    Purpose: Breast cancer is the most common malignancy among young women of reproductive age. Adjuvant treatment with tamoxifen reduces the risk of recurrence in hormone-sensitive breast cancer. However, the use of tamoxifen ...
  • Autosomal dominant Marfan syndrome caused by a previously reported recessive FBN1 variant 
    Overwater, Eline; Efrat, Rifka; Barge-Schaapveld, Daniela Q C M; Lakeman, Phillis; Weiss, Marjan M; Maugeri, Alessandra; van Tintelen, J Peter; Houweling, Arjan C (John Wiley & Sons Inc., 2019-02)
    BACKGROUND: Pathogenic variants in FBN1 cause autosomal dominant Marfan syndrome but can also be found in patients presenting with apparently isolated features of Marfan syndrome. Moreover, several families with autosomal ...
  • Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use 
    CHD Exome+ Consortium; Consortium for Genetics of Smoking Behaviour (Elsevier, 2019-06-01)
    Background: Smoking and alcohol use have been associated with common genetic variants in multiple loci. Rare variants within these loci hold promise in the identification of biological mechanisms in substance use. Exome ...
  • Microbiome Analytics of the Gut Microbiota in Patients With Juvenile Idiopathic Arthritis: A Longitudinal Observational Cohort Study 
    van Dijkhuizen, E. H.Pieter; Del Chierico, Federica; Malattia, Clara; Russo, Alessandra; Pires Marafon, Denise; ter Haar, Nienke M.; Magni-Manzoni, Silvia; Vastert, Sebastiaan J.; Dallapiccola, Bruno; Prakken, Berent; Martini, Alberto; De Benedetti, Fabrizio; Putignani, Lorenza; the Model Driven Paediatric European Digital Repository Consortium (John Wiley & Sons Inc., 2019-06-01)
    OBJECTIVE: To assess the composition of gut microbiota in Italian and Dutch patients with juvenile idiopathic arthritis (JIA) at baseline, with inactive disease, and with persistent activity compared to healthy controls. ...
  • European validation of the Yonsei Gastric Cancer Prognosis Prediction Model after gastrectomy: Validation with the Netherlands Cancer Registry 
    Brenkman, Hylke J F; Cho, Minah; Ruurda, Jelle P; Song, Kijun; Son, Taeil; Kim, Hyoung-Il; Noh, Sung Hoon; van Hillegersberg, Richard; Hyung, Woo Jin (W.B. Saunders Ltd, 2019-06)
    Background: Recently, a novel model predicting 5-year survival after gastrectomy was developed, the Yonsei Gastric Cancer Prognosis Prediction Model, to overcome limitations of the tumor-node-metastases (TNM)staging system. ...
  • Behavior problems and health-related quality of life in Dravet syndrome 
    Sinoo, Claudia; de Lange, Iris Marie Louise; Westers, Paul; Gunning, Willem Boudewijn; Jongmans, Marian Jacqueline; Brilstra, Eva Henriëtte (Academic Press Inc., 2019-01)
    Objective: Behavior problems in Dravet syndrome (DS) are common and can impact the lives of patients tremendously. The current study aimed to give more insight into (1) the prevalence of a wide range of specific behavior ...
  • Salvage Surgery for Recurrence after Radiotherapy for Squamous Cell Carcinoma of the Head and Neck 
    Elbers, Joris B W; Al-Mamgani, Abrahim; van den Brekel, Michiel W M; Jóźwiak, Katarzyna; de Boer, J P; Lohuis, Peter J F M; Willems, Stefan M; Verheij, Marcel; Zuur, Charlotte L (Mosby Inc., 2019-06)
    OBJECTIVE: Most studies that report on salvage surgery after primary radiotherapy for head and neck squamous cell carcinoma (HNSCC) are small and heterogeneous. Subsequently, some relevant questions remain unanswered. We ...