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Now showing items 22161-22180 of 40729

Restabilization treatment after intravenous immunoglobulin withdrawal in chronic inflammatory demyelinating polyneuropathy: Results from the pre-randomization phase of the Polyneuropathy And Treatment with Hizentra study

Mielke, Orell; Bril, Vera; Cornblath, David R; Lawo, John-Philip; van Geloven, Nan; Hartung, Hans-Peter; Lewis, Richard A; Merkies, Ingemar S J; Sobue, Gen; Durn, Billie; Shebl, Amgad; van Schaik, Ivo N; PATH study group (Wiley-Blackwell, 2019-03)

In patients with chronic inflammatory demyelinating polyneuropathy (CIDP), intravenous immunoglobulin (IVIG) is recommended to be periodically reduced to assess the need for ongoing therapy. However, little is known about ...
Unconsented genetic testing in psychiatry: an (almost) no go?

Luykx, Jurjen J.; van der Spek, Rick; van Veen, Sisco; Lo-A-Foe, Wonnie; Giesbertz, Noor A.A.; Bredenoord, Annelien L.; Palmboom, Ger G. (Elsevier Limited, 2019-08-01)
Genetic defect of the sodium-dependent multivitamin transporter: A treatable disease, mimicking biotinidase deficiency

Schwantje, Marit; de Sain-van der Velden, Monique; Jans, Judith; van Gassen, Koen; Dorrepaal, Charlotte; Koop, Klaas; Visser, Gepke (Springer Berlin, 2019-07)

The sodium-dependent multivitamin transporter that facilitates the uptake of the water-soluble vitamins biotin, pantothenic acid, and the vitamin-like substance lipoate is coded by the SLC5A6 gene. Variants in this gene ...
Calcifying fibrous tumor and inflammatory myofibroblastic tumor are epigenetically related: A comparative genome-wide methylation study

Tomassen, Tess; Koelsche, Christian; de Leng, Wendy W.J.; Kommoss, Felix K.F.; Voijs, Carmen M.A.; Peeters, Ton; van Noesel, Max M.; Creytens, David; van Gorp, Joost M.; Petersen, Iver; Vokuhl, Christian; von Deimling, Andreas; Mentzel, Thomas; Flucke, Uta (W.B. Saunders, 2019-08-01)

Based on histological findings, calcifying fibrous tumor (CFT) may be a late (burned out) stage of inflammatory myofibroblastic tumor (IMT). This concept, however, has not been proven by molecular means. Five CFTs were ...
Epigenetic drug screen identifies the histone deacetylase inhibitor NSC3852 as a potential novel drug for the treatment of pediatric acute myeloid leukemia

Wiggers, Caroline R M; Govers, Anita M A P; Lelieveld, Daphne; Egan, David A; Zwaan, C Michel; Sonneveld, Edwin; Coffer, Paul J; Bartels, Marije (Wiley-Liss Inc., 2019-08)

BACKGROUND: Acute myeloid leukemia (AML) is a heterogeneous disease regarding morphology, immunophenotyping, genetic abnormalities, and clinical behavior. The overall survival rate of pediatric AML is 60% to 70%, and has ...
Phase I/II Study of Stem-Cell Transplantation Using a Single Cord Blood Unit Expanded Ex Vivo With Nicotinamide

Horwitz, Mitchell E; Wease, Stephen; Blackwell, Beth; Valcarcel, David; Frassoni, Francesco; Boelens, Jaap Jan; Nierkens, Stefan; Jagasia, Madan; Wagner, John E; Kuball, Jurgen; Koh, Liang Piu; Majhail, Navneet S; Stiff, Patrick J; Hanna, Rabi; Hwang, William Y K; Kurtzberg, Joanne; Cilloni, Daniela; Freedman, Laurence S; Montesinos, Pau; Sanz, Guillermo (Lippincott Williams & Wilkins, 2019-02-10)

PURPOSE Increasing the number of hematopoietic stem and progenitor cells within an umbilical cord blood (UCB) graft shortens the time to hematopoietic recovery after UCB transplantation. In this study, we assessed the ...
A survey of undetected, clinically relevant chromosome abnormalities when replacing postnatal karyotyping by Whole Genome Sequencing

Hochstenbach, Ron; van Binsbergen, Ellen; Schuring-Blom, Heleen; Buijs, Arjan; Ploos van Amstel, Hans Kristian (Elsevier Masson SAS, 2019-09)

Whole genome sequencing (WGS) holds the potential to identify pathogenic gene mutations, copy number variation, uniparental disomy and structural rearrangements in a single genetic test. With its high diagnostic yield and ...
Visie op toekomstige surveillance van respiratoire bacteriële pathogenen

Mariman, Rob; Bosch, Thijs; Miellet, Willem; Pluister, Gerlinde N.; van Veldhuizen, Janieke; Sanders, Elisabeth; Trzcinski, Krzysztof (Elsevier, 2019)

The link between carriage and disease is utilized in monitoring effects of vaccines targeting respiratory bacteria. The gold standard for carriage detection is the culturing of live bacteria from nasopharyngeal (pneumococcus) ...
IGF and mTOR pathway expression and in vitro effects of linsitinib and mTOR inhibitors in adrenocortical cancer

De Martino, Maria Cristina; van Koetsveld, Peter M.; Feelders, Richard A.; de Herder, Wouter W.; Dogan, Fadime; Janssen, Joseph A.M.J.L.; Hofste op Bruinink, Davine; Pivonello, Claudia; Waaijers, A. Marlijn; Colao, Annamaria; de Krijger, Ronald R.; Pivonello, Rosario; Hofland, Leo J. (Humana Press, 2019-06-15)

Purpose: The IGF and mTOR-pathways are considered as potential targets for therapy in patients with adrenocortical carcinoma (ACC). This study aims to describe the IGF pathway in ACC and to explore the response to the ...
Association of PDGFRB Mutations with Pediatric Myofibroma and Myofibromatosis

Dachy, Guillaume; De Krijger, Ronald R.; Fraitag, Sylvie; Théate, Ivan; Brichard, Bénédicte; Hoffman, Suma B.; Libbrecht, Louis; Arts, Florence A.; Brouillard, Pascal; Vikkula, Miikka; Limaye, Nisha; Demoulin, Jean Baptiste (American Medical Association, 2019-08-01)

Importance: Myofibroma is the most frequent fibrous tumor in children. Multicentric myofibroma (referred to as infantile myofibromatosis) is a life-threatening disease. Objective: To determine the frequency, spectrum, and ...
Molecular alterations in dog pheochromocytomas and paragangliomas

Korpershoek, Esther; Dieduksman, Daphne A.E.R.; Grinwis, Guy C.M.; Day, Michael J.; Reusch, Claudia E.; Hilbe, Monika; Fracassi, Federico; Krol, Niels M.G.; Uitterlinden, André G.; De Klein, Annelies; Eussen, Bert; Stoop, Hans; De Krijger, Ronald R.; Galac, Sara; Dinjens, Winand N.M. (Multidisciplinary Digital Publishing Institute (MDPI), 2019-05-01)

Recently, genetic alterations in the genes encoding succinate dehydrogenase subunit B and D (SDHB and SDHD) were identified in pet dogs that presented with spontaneously arising pheochromocytomas (PCC) and paragangliomas ...
An Update on the Histology of Pheochromocytomas: How Does it Relate to Genetics?

Oudijk, Lindsey; Gaal, José; Koopman, Karen; De Krijger, Ronald R. (Georg Thieme Verlag, 2019-01-01)

Pheochromocytomas are rare neuroendocrine tumors of the adrenal gland, whereas any extra-adrenal tumor with similar histology is designated as paraganglioma. These tumors have a very high rate of germline mutations in a ...
Pheochromocytomas and paragangliomas: New developments with regard to classification, genetics, and cell of origin

Koopman, Karen; Gaal, Jose; de Krijger, Ronald R. (Multidisciplinary Digital Publishing Institute (MDPI), 2019-08-01)

Pheochromocytomas (PCC) and paragangliomas (PGL) are rare neuroendocrine tumors that arise in the adrenal medulla and in extra-adrenal locations, such as the head, neck, thorax, abdomen, and pelvis. Classification of these ...
Incidence of and Risk Factors for Histologically Confirmed Solid Benign Tumors among Long-term Survivors of Childhood Cancer

Kok, Judith L.; Teepen, Jop C.; Van Der Pal, Helena J.; Van Leeuwen, Flora E.; Tissing, Wim J.E.; Neggers, Sebastian J.C.M.M.; Loonen, Jacqueline J.; Louwerens, Marloes; Versluys, Birgitta; Van Den Heuvel-Eibrink, Marry M.; Van Dulmen-Den Broeder, Eline; Jaspers, Monique M.W.; Van Santen, Hanneke M.; Van Der Heiden-Van Der Loo, Margriet; Janssens, Geert O.; Maduro, John H.; Bruggink, Annette H.; Jongmans, Marjolijn C.; Kremer, Leontien C.M.; Ronckers, Cécile M. (American Medical Association, 2019-05-01)

Importance: Survivors of childhood cancer (CCSs) face risk of developing subsequent tumors. Solid benign tumors may be cancer precursors; benign tumors and cancers may share etiologic factors. However, comprehensive data ...
A decrease in vitamin D levels is associated with methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia

Oosterom, N.; Dirks, N. F.; Heil, S. G.; de Jonge, R.; Tissing, W. J.E.; Pieters, R.; van den Heuvel-Eibrink, M. M.; Heijboer, A. C.; Pluijm, S. M.F. (Springer-Verlag, 2019-01-01)

PURPOSE: Children with acute lymphoblastic leukemia (ALL) are at increased risk of vitamin D deficiency, which might make them more susceptible to developing adverse events. Previous studies showed that low vitamin D levels ...
Uterine function, pregnancy complications, and pregnancy outcomes among female childhood cancer survivors

DCOG-LATER Study Group (Elsevier, 2019-02-01)

OBJECTIVE: To evaluate whether abdominal-pelvic radiotherapy for childhood cancer impairs uterine function and increases the risk of pregnancy complications and adverse pregnancy outcomes. DESIGN: Nested cohort study. ...
The involvement of primary care physicians in care for childhood cancer survivors

DCOG-LATER Study Group (Wiley-Liss Inc., 2019-08-01)

Background: Childhood cancer survivors (CCS) are at risk of developing long-term morbidity, which is likely to be presented to a primary care physician (PCP). Therefore, insight into CCS's PCP-based health care use is ...
Long-Term Risk of Skin Cancer among Childhood Cancer Survivors: A DCOG-LATER Cohort Study

Teepen, Jop C.; Kok, Judith L.; Kremer, Leontien C.; Tissing, Wim J.E.; Van Den Heuvel-Eibrink, Marry M.; Loonen, Jacqueline J.; Bresters, Dorine; Van Der Pal, Helena J.; Versluys, Birgitta; Van Dulmen-Den Broeder, Eline; Nijsten, Tamar; Hauptmann, Michael; Hollema, Nynke; Dolsma, Wil V.; Van Leeuwen, Flora E.; Ronckers, Cécile M. (Oxford University Press, 2019-08-01)

BACKGROUND: Skin cancer is common after radiotherapy among childhood cancer survivors (CCSs). We studied risks and risk factors for subsequent skin cancers, with emphasis on radiation dose, exposed skin surface area, and ...
Clinical characteristics and survival patterns of subsequent sarcoma, breast cancer, and melanoma after childhood cancer in the DCOG-LATER cohort

DCOG-LATER Study Group (Springer Netherlands, 2019-09-01)

Purpose: Childhood cancer survivors are at increased risk of developing subsequent malignant neoplasms (SMNs). We compared survival and clinical characteristics of survivors with SMNs (sarcoma, breast cancer, or melanoma) ...
Building a Professional Identity and an Academic Career Track in Translational Medicine

van Dijk, Sabine J; Domenighetti, Andrea A; Gomez-Ospina, Natalia; Hunter, Patricia; Lindemans, Caroline A; Melotte, Veerle; van Rossum, Annemarie M C; Rosenblum, Norman D (Frontiers Media S. A., 2019)

Biomedical scientists aim to contribute to further understanding of disease pathogenesis and to develop new diagnostic and therapeutic tools that relieve disease burden. Yet the majority of biomedical scientists do not ...

Now showing items 22161-22180 of 40729