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UMC Repository: Recent submissions

  • Therapeutic Strategies for Mesenchymal Type Colorectal Cancer 
    Ubink, Inge (2020-03-12)
    Colorectal cancer is a heterogeneous disease. We are unable to predict which colorectal cancer patients will develop metastases, and which adjuvant therapy is required to prevent outgrowth of metastases in the individual ...
  • MSI as a predictive factor for treatment outcome of gastroesophageal adenocarcinoma 
    van Velzen, M J M; Derks, S; van Grieken, N C T; Haj Mohammad, N; van Laarhoven, H W M (W.B. Saunders Ltd, 2020-06)
    Gastroesophageal cancers are a major cause of death worldwide and treatment outcomes remain poor. Adequate predictive biomarkers have not been identified. Microsatellite instability (MSI) as a result of mismatch repair ...
  • Low interrater reliability of brachial plexus MRI in chronic inflammatory neuropathies 
    van Rosmalen, Marieke H J; Goedee, H Stephan; van der Gijp, Anouk; Witkamp, Theo D; Froeling, Martijn; Hendrikse, Jeroen; van der Pol, W Ludo (John Wiley & Sons Inc., 2020-06-01)
    Introduction: Magnetic resonance imaging of the brachial plexus shows nerve thickening in approximately half of the patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy ...
  • Neutrophil biomarkers after trauma : A first step towards immune-based decision making 
    Lilian, Hesselink (Utrecht University, 2020-06-12)
    About halve of the severely injured (polytrauma) patients develop an infectious complication during hospital admission. Such an infection can cause organ failure and sometimes even death in these patients. The neutrophil ...
  • Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids 
    Dekkers, Johanna F.; Whittle, James R.; Vaillant, François; Chen, Huei Rong; Dawson, Caleb; Liu, Kevin; Geurts, Maarten H.; Herold, Marco J.; Clevers, Hans; Lindeman, Geoffrey J.; Visvader, Jane E. (Oxford University Press, 2020-05-01)
    Breast cancer is characterized by histological and functional heterogeneity, posing a clinical challenge for patient treatment. Emerging evidence suggests that the distinct subtypes reflect the repertoire of genetic ...
  • Evolutionary Dynamics of the Spindle Assembly Checkpoint in Eukaryotes 
    Kops, Geert J.P.L.; Snel, Berend; Tromer, Eelco C. (Cell Press, 2020-05-18)
    The tremendous diversity in eukaryotic life forms can ultimately be traced back to evolutionary modifications at the level of molecular networks. Deep understanding of these modifications will not only explain cellular ...
  • Benefits and Risks of Primary Treatments for High-risk Localized and Locally Advanced Prostate Cancer: An International Multidisciplinary Systematic Review 
    Moris, Lisa; Cumberbatch, Marcus G; Van den Broeck, Thomas; Gandaglia, Giorgio; Fossati, Nicola; Kelly, Brian; Pal, Raj; Briers, Erik; Cornford, Philip; De Santis, Maria; Fanti, Stefano; Gillessen, Silke; Grummet, Jeremy P; Henry, Ann M; Lam, Thomas B L; Lardas, Michael; Liew, Matthew; Mason, Malcolm D; Omar, Muhammad Imran; Rouvière, Olivier; Schoots, Ivo G; Tilki, Derya; van den Bergh, Roderick C N; van Der Kwast, Theodorus H; van Der Poel, Henk G; Willemse, Peter-Paul M; Yuan, Cathy Y; Konety, Badrinath; Dorff, Tanya; Jain, Suneil; Mottet, Nicolas; Wiegel, Thomas (Elsevier, 2020-05)
    High-risk and locally advanced prostate cancer (PCa) patients are likely to undergo multimodality treatment. Patients should at all times be fully informed about all available options and the likelihood of a multimodal ...
  • Comparative performance of pooled cohort equations and Framingham risk scores in cardiovascular disease risk classification in a slum setting in Nairobi Kenya 
    Wekesah, Frederick M.; Mutua, Martin K.; Boateng, Daniel; Grobbee, Diederick E.; Asiki, Gershim; Kyobutungi, Catherine K.; Klipstein-Grobusch, Kerstin (Elsevier, 2020-06-01)
    Background: Cardiovascular diseases (CVD) cause 18 million deaths annually. Low- and middle-income countries (LMICs) account for 80% of the CVD burden, and the burden is expected to grow in the region in the coming years. ...
  • Effects of distraction on taste-related neural processing: a cross-sectional fMRI study 
    Duif, Iris; Wegman, Joost; Mars, Monica M; de Graaf, Cees; Smeets, Paul A M; Aarts, Esther (Elsevier, 2020-05-01)
    Background: In the current obesogenic environment we often eat while electronic devices, such as smart phones, computers, or the television, distract us. Such "distracted eating"is associated with increased food intake and ...
  • Timing of procedural stroke and death in asymptomatic patients undergoing carotid endarterectomy: individual patient analysis from four RCTs 
    Carotid Stenosis Trialists’ Collaboration (John Wiley & Sons Inc., 2020-05-01)
    Background: The effectiveness of carotid endarterectomy (CEA) for stroke prevention depends on low procedural risks. The aim of this study was to assess the frequency and timing of procedural complications after CEA, which ...
  • Oligometastatic Prostate Cancer : Results of a Dutch Multidisciplinary Consensus Meeting 
    Dutch Oligometastatic Prostate Cancer Working Group (2020-04)
    Background: Oligometastatic prostate cancer (OMPC) is a heterogeneous disease state that is imperfectly understood, and its clinical implications are unclear. Objective: To determine the consensus of a Dutch multidisciplinary ...
  • Management of extracranial arteriovenous malformations of the head and neck 
    Fernández-Alvarez, Veronica; Suárez, Carlos; de Bree, Remco; Nixon, Iain J; Mäkitie, Antti A; Rinaldo, Alessandra; Downer, Jonathan; Ferlito, Alfio (Elsevier Ireland Ltd, 2020-04)
    The purpose of this study was to review the outcomes of the different therapies for extracranial head and neck arteriovenous malformations (AVMs). AVMs are high-flow congenital vascular anomalies. They are composed of a ...
  • Diffusion tensor imaging of the human thigh: consideration of DTI-based fiber tracking stop criteria 
    Forsting, Johannes; Rehmann, Robert; Froeling, Martijn; Vorgerd, Matthias; Tegenthoff, Martin; Schlaffke, Lara (Springer-Verlag, 2020-05)
    Objectives: To consider the tract-based analysis of DTI parameters in human muscle by assessing different fiber tracking stop criteria settings on diffusion parameters. Materials and methods: 30 healthy volunteers underwent ...
  • Early-life exposures and cardiovascular disease risk among Ghanaian migrant and home populations: the RODAM study 
    Boateng, Daniel; Danquah, Ina; Said-Mohamed, Rihlat; Smeeth, Liam; Nicolaou, Mary; Meeks, Karlijn; Beune, Erik; Addo, Juliet; Bahendeka, Silver; Agyei-Baffour, Peter; Mockenhaupt, Frank P; Spranger, Joachim; Schulze, Matthias B; Grobbee, Diederick E; Agyemang, Charles; Klipstein-Grobusch, Kerstin (Cambridge University Press, 2020-06)
    Early-life environmental and nutritional exposures are considered to contribute to the differences in cardiovascular disease (CVD) burden. Among sub-Saharan African populations, the association between markers of early-life ...
  • Pre-diagnostic plasma bile acid levels and colon cancer risk: A prospective study 
    Kühn, Tilman; Stepien, Magdalena; López-Nogueroles, Marina; Machado, Antje Damms; Sookthai, Disorn; Johnson, Theron; Roca, Marta; Hüsing, Anika; Maldonado, Sandra González; Cross, Amanda J; Murphy, Neil; Freisling, Heinz; Rinaldi, Sabina; Scalbert, Augustin; Fedirco, Veronika; Severi, Gianluca; Boutron-Ruault, Marie-Christine; Mancini, Francesca Romana; Sowah, Solomon A; Boeing, Heiner; Jakszyn, Paula; Sánchez, Maria-Jose; Merino, Susana; Colorado-Yohar, Sandra; Barricarte, Aurelio; Khaw, Kay Tee; Schmidt, Julie A; Perez-Cornago, Aurora; Trichopoulou, Antonia; Karakatsani, Anna; Thriskos, Paschalis; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Sacerdote, Carlotta; Panico, Salvatore; Bueno-de-Mesquita, Bas; van Gils, Carla H; Heath, Alicia; Gunter, Marc J; Riboli, Elio; Lahoz, Agustín; Jenab, Mazda; Kaaks, Rudolf (Oxford University Press, 2020-05-01)
    BACKGROUND: Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans. METHODS: Associations between prediagnostic ...
  • Q fever in the Netherlands: Occupational exposure, pregnancy outcomes, and chronic Q fever screening 
    Lange, Maria Margaretha Alida de (Utrecht University, 2020-05-25)
    Many sheep farm residents and veterinary students experienced a Q fever infection in the past, while only a few have had complaints of the acute illness. However, these people may still be at risk of a chronic infection. ...
  • Keeping antibiotic resistance at bay Hospital-based surveillance of antibiotic-resistant Gram-negative bacteria 
    Hout, Denise van (Utrecht University, 2020-05-19)
    The human body is colonised with millions of bacteria, which are usually innocent. These bacteria can also become invasive and cause infections, prompting antibiotic treatment. Bacteria can become resistant to certain or ...
  • Unmasking in vivo stem cell dynamics in mammary tissue and mammary tumors 
    Scheele, Levina Geertruida Jacoba (Utrecht University, 2020-05-07)
    Over the past decades, researchers have been trying to find the stem cells responsible for the development and homeostasis of the mammary gland. However, because of the lack of stem cell markers, the mammary stem cell ...
  • Role of novel predictive factors on clinical outcome after transcatheter aortic valve replacement 
    Abawi, Masieh (Utrecht University, 2020-05-18)
    In Chapter 2 we investigated the incidence, predictors, and prognostic effect of delirium on outcome after TAVR. Interestingly, we observed that delirium occurs among 13.4% of patients undergoing TAVR, and more commonly ...
  • Circulating phylloquinone, inactive Matrix Gla protein and coronary heart disease risk: A two-sample Mendelian Randomization study 
    Zwakenberg, Sabine R; Burgess, Stephen; Sluijs, Ivonne; Weiderpass, Elisabete; Beulens, Joline W J; van der Schouw, Yvonne T (Churchill Livingstone, 2020-04-01)
    BACKGROUND AND AIMS: Multiple observational studies and small-scale intervention studies suggest that high vitamin K intake is associated with improved markers for cardiovascular health. Circulating phylloquinone solely ...