Circulating phylloquinone, inactive Matrix Gla protein and coronary heart disease risk: A two-sample Mendelian Randomization study

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Circulating phylloquinone, inactive Matrix Gla protein and coronary heart disease risk: A two-sample Mendelian Randomization study
 
Zwakenberg, Sabine R; Burgess, Stephen; Sluijs, Ivonne; Weiderpass, Elisabete; Beulens, Joline W J; van der Schouw, Yvonne T
(2020) Clinical Nutrition, volume 39, issue 4, pp. 1131 - 1136
(Article)
Abstract
BACKGROUND AND AIMS: Multiple observational studies and small-scale intervention studies suggest that high vitamin K intake is associated with improved markers for cardiovascular health. Circulating phylloquinone solely represents phylloquinone (vitamin K1) intake, while dephosphorylated uncarboxylated Matrix Gla Protein (dp-ucMGP) represents both phylloquinone and menaquinone (vitamin K2) intake. This study aims ... read more
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Keywords: Coronary heart disease, Epidemiology, Matrix Gla protein, Mendelian randomization, Phylloquinone, Vitamin K, Nutrition and Dietetics, Critical Care and Intensive Care Medicine
DOI: https://doi.org/10.1016/j.clnu.2019.04.024
ISSN: 0261-5614
Publisher: Churchill Livingstone
Note: Funding Information: We thank all EPIC participants and staff for their contribution to the study. We thank staff from the EPIC-CVD and EPIC-InterAct Coordinating Centres for carrying out sample preparation and data-handling work, particularly Sarah Spackman (EPIC-CVD Data Manager) and Nicola Kerrison (EPIC-InterAct Data Manager). EPIC-CVD has been supported by the European Union Framework 7 ( HEALTH-F2-2012-279233 ), the European Research Council ( 268834 ), the UK Medical Research Council ( G0800270 and MR/L003120/1 ), the British Heart Foundation ( SP/09/002 and RG/08/014 and RG13/13/30194 ), and the UK National Institute of Health Research . The establishment of the random subcohort was supported by the EU Sixth Framework Programme (grant LSHM_CT_2006_037197 to the InterAct project) and the Medical Research Council Epidemiology Unit (grants MC_UU_12015/1 and MC_UU_12015/5 ). The coordination of EPIC is financially supported by the European Commission and the International Agency for Research on Cancer . The funders played no role in the design of the study; the collection, analysis, and interpretation of the data; or the decision to approve publication of the finished manuscript. Funding Information: SRZ and JWJB are supported by the Senior Dr. Dekker grant ( 2013T120 ) from The Dutch Heart Foundation . IS is supported by a personal Dr. Dekker Junior Postdoctoral grant (2015T19) from The Dutch Heart Foundation. The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Publisher Copyright: © 2019 The Author(s)
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