Aims and objectives: To identify interventions to prevent and treat malnutrition in older adults, which can be integrated in nursing care, and to evaluate the effects of these interventions on outcomes related to malnutrition. ...

BACKGROUND: Coronary artery disease (CAD) will increasingly determine outcome in the aging adult congenital heart disease (CHD) population. We aimed to determine sex-specific incidence of CAD in adult CHD patients throughout ...

Therapeutic monoclonal antibodies are widely used for the treatment of various diseases were conventional small molecule based drugs are not effective. For patients with inflammatory autoimmune disease for example, the ...

This thesis concerns the Unity MRI-linac (and its prototypes). The overall aim was to ensure that the MRI-linac was safe and effective for clinical use, and could be introduced into the clinic. To this end it was necessary ...

Globally, stroke affects 16 million individuals every year. Patients who survive a stroke are at high risk for recurrent stroke and other cardiovascular events. In the next decades, the prevalence of stroke is expected to ...

The pharmacological and physiological profiles of progestogens used for luteal phase support during assisted reproductive technology are likely to be important in guiding clinical choice towards the most appropriate treatment ...

Background: Fertility rates in Europe are among the lowest in the world, which may be attributed to both biological and lifestyle factors. Cost and reimbursement of fertility treatments vary across Europe, although its ...

Cancer is a genetic disease characterized by the unrestrained proliferation of malignantly transformed cells. In this thesis we study the mechanisms of resistance to targeted therapeutics, drugs that target specifically ...