Accurate and fast diagnostic tests for sepsis are important to improve patient outcomes. This thesis discusses different diagnostic approaches for sepsis. There exists no perfect gold standard for sepsis, which complicates ...

In this thesis, we have described organoids as a model to study developmental cues underpinning homeostatic turnover with a focus on the intestine and its hormone-producing enteroendocrine cells ...

This thesis reports upon clinical outcomes of atrioventricular septal defect (AVSD) repair and of left atrioventricular valve (LAVV) replacement in neonates, infants and adults and reports upon outcomes hypoplastic left ...

Ion channel trafficking, this is the transport of ion channel proteins within the heart cell, is an underestimated cause of severe cardiac arrhythmias. Importantly, it is often missed in initial cardiac safety assessment ...

A large body of previous research indicates the importance of dynamics in transcription regulation, yet our understanding of this aspect is quite poor. The overall aim of the work described in this thesis is to study ...

Hospitals are being challenged to deliver high quality of care while demands are increasing and budgets are shrinking. Nurses are pivotal in delivering high quality of care and have a significant influence on patient ...

Patients with spinal cord injury or acquired brain injury often receive rehabilitation treatment. Treatment is mainly aimed to optimize independent functioning, and to learn how to cope with the new situation. There is ...