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Π-π Stacked Polymeric Micelles as Carriers of Anticancer Therapeutics for Hematological Malignancies

Varela Moreira, Aida Alexandra (Utrecht University, 2020-09-28)

The research presented in this thesis explores mPEG-b-p(HPMA-Bz)-based micelles as nanocarriers for cancer treatment, with focus on hematological cancers. PM showed good circulation and attractive tissue distribution in ...
Novel computational approaches to predict and reconstruct bacterial plasmids: Focus on the nosocomial pathogen Enterococcus faecium

Arredondo Alonso, Sergio (Utrecht University, 2020-09-21)

Plasmids are extrachromosomal elements that can disseminate between strains or even between different bacterial species. Plasmids can also acquire novel genetic traits by acquisition of transposons or cointegration with ...
Evaluation of a stepwise prevention program for cardiometabolic diseases in primary care

Badenbroek, Ilse Francis (Utrecht University, 2020-09-22)

In order to anticipate the increasing burden of disease of cardiometabolic diseases (CMD), such as cardiovascular disease, diabetes mellitus type 2 and chronic kidney damage, the Dutch College of General Practitioners ...
Studying Prognosis and Treatment in Patients with Neuroendocrine Neoplasia

van Veenendaal, Linde Michèle (Utrecht University, 2020-09-17)

Neuroendocrine neoplasia (NEN) are often referred to as a homogeneous group of malignancies, especially gastroenteropancreatic neuroendocrine tumours (GEP-NETs). Although they might appear similar histologically, they ...
PERINATAL ASPHYXIA: PREDICTING AND IMPROVING OUTCOME

Annink, Kim Valerie (Utrecht University, 2020-09-24)

• Diffusion weighted imaging might underestimate cerebellar injury in neonates with hypoxic-ischemic encephalopathy (HIE), especially in the cerebellar hemispheres. If the apparent diffusion coefficient (ADC) values are ...
Strategies for prevention and treatment of delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage

Gathier, Celine Sophia (Utrecht University, 2020-09-24)

In this thesis, risk factors and treatment strategies for delayed cerebral ischaemia (DCI) are discussed. In Chapter 2 we showed in 333 aSAH patients that total haemorrhage volume, quantified with an automatic quantification ...
Aggression in Psychiatry: prevention, epidemiology & treatment

Faay, Margo Désirée Maria (Utrecht University, 2020-09-23)

Introduction Aggression is a major problem within psychiatry. The aim of this thesis is to contribute to the current knowledge about aggression in psychiatry with clinically relevant results and insights. This thesis ...
Machine learning for automatic segmentation of neonatal and fetal MR brain images

Khalili, Nadieh (Utrecht University, 2020-09-22)

Fetal MRI is widely used to investigate brain development in utero. MR images do not only visualize brain tissue classes and identify abnormalities but are also able to quantify brain development using volumetric measurements ...
Delirium as a disorder of brain network disintegration

van Montfort, Simone Jozefa Theodora (Utrecht University, 2020-09-22)

Delirium is a common neuropsychiatric syndrome, characterized by acute change in attention and awareness, as direct consequence of an underlying medical condition. It is affecting 10-50% of the hospitalized elderly. ...
MODELING VERTEBRATE ADULT STEM CELLS AND THEIR PROGENY

Post, Yorick (Utrecht University, 2020-09-21)

The adult human body consists of trillions of cells. These cells are the building blocks for every organ and tissue in the body. During our lifetime, cells are constantly lost at different speeds due to natural turnover ...
GESTATIONAL DIABETES MELLITUS: Challenges in diagnostics, management and impact

de Wit, Leon (Utrecht University, 2020-09-28)

Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders of pregnancy and is characterized by hyperglycemia. GDM is associated with adverse short- and long term outcomes of both mothers and their ...
The Rotterdam Diabetic Foot Study A different view on lower extremity neuropathy: a new hope against the phantom menace?

Rinkel, Willem Daniël (Utrecht University, 2020-09-15)

The first reports from the Rotterdam Diabetic Foot (RDF) Study described in this thesis show that diabetes-induced sensory loss is gradable with simple to use instruments. This grading allows stratifying those at risk for ...
Noncytotoxic functions of granzymes in inflammation and antiviral immunity

Shan, Liling (Utrecht University, 2020-09-08)

Cytotoxic lymphocytes, including cytotoxic (CD8+) T lymphocytes, natural killer (NK) cells, NKT, and gamma delta (γδ) T cells, play crucial roles in inflammation, antitumor, and antiviral immunity. Upon activation, cytotoxic ...
Utilizing organoids to study general and tissue-specific adult stem cell profiles: Exploiting organoid cultures for basic stem cell research

Boonekamp, Kim Elisabeth (Utrecht University, 2020-09-15)

In this thesis we describe our efforts to expand the organoid technology toolbox and to utilize organoid technology for basic stem cell research. Organoid technology allows for culturing primary cells from adult tissues ...
Another look at human granulocyte kinetics

Hassani, Marwan (Utrecht University, 2020-09-14)

This thesis mainly focuses on the lifespan of granulocytes in healthy humans and in patients with asthma. Using a non-toxic label in humans, called deuterated glucose, we discovered that neutrophils, have a longer ...
Technical Development of Interventional Nuclear Imaging

Dietze, Martijn Michiel Alexander (Utrecht University, 2020-09-17)

This dissertation has introduced several methodological contributions that are required to enable nuclear image guidance in the interventional suite. The contributions have primarily been evaluated for use in radioembolization ...
Time activity patterns in exposure assessment: the case of livestock related infections

Klous, Gijs (Utrecht University, 2020-09-17)

Summary Between 2007 and 2010 the Netherlands experienced the largest documented Q fever outbreak to date. This outbreak and several other incidents with infectious disease spill-overs from livestock to humans, initiated ...
The bumpy road to effective hamstring injury prevention in male amateur soccer players: Risk factors, plyometric training, adherence, return-to-play and prognostic factors

van de Hoef, Peter Alexander (Utrecht University, 2020-09-15)

Hamstring injuries are the most common muscle injuries in soccer and therefore a major concern in male amateur soccer players. Besides the high incidence, these injuries cause long absence of play and have high reinjury ...
Inflammation in Heart Failure: Is our immune response failing our heart?

van den Hoogen, Patricia (Utrecht University, 2020-09-14)

Heart failure (HF) is one of the most common cardiovascular diseases, affecting approximately 26 million people worldwide and is characterized by adverse cardiac remodeling and a reduced ability of the heart to maintain ...
mpMRI based targeted biopsy of the prostate: Is there a preferred technique?

Wegelin, Olivier (Utrecht University, 2020-09-14)

Part III: Outcomes of the FUTURE trial In chapter 5 the primary outcomes of the FUTURE trial are presented. Among the 665 recruited patients, 234 (35%) had PIRADS≥3 lesions on mpMRI and were randomised for subsequent ...

Now showing items 21361-21380 of 40729