Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 21401-21420 of 40729

Tumor organoids as a personalized model of human cancer

Kristian Dijkstra, Krijn (Utrecht University, 2020-02-20)

Tumor organoids are 3D cultures of cancer cells. Research into the applications of tumor organoids as a model system for cancer has received great interest. Here, we critically evaluate which opportunities this model systems ...
Data-driven modeling of the neural dynamics underlying language processing

Berezutskaya, Julia (Utrecht University, 2020-04-14)

In this thesis, we use data-driven techniques in an attempt to explain the neural data during speech and language perception in unconstrained naturalistic setup. We aim to use a combination of data exploration approaches ...
On the treatment of zygomaticomaxillary complex fractures: Intraoperative imaging

van Hout, Walter Marinus Michaël Theodoor (Utrecht University, 2020-07-07)

Traffic accidents are the most common cause of maxillofacial fractures in the Dutch population. Therefore preventive measures aimed at decreasing the incidence of maxillofacial fractures are likely to be most efficacious ...
Modulating human iPSC-CM electrophysiology for in vitro drug screening

Goversen, Birgit (Utrecht University, 2020-07-09)

Every year drugs are retracted from the market due to serious side effects, of which 45% negatively influences heart rhythm. This can be prevented with proper testing during drug development to determine the safety for the ...
Use of anesthesia data for research

Pasma, Wietze (Utrecht University, 2020-07-07)

In CHAPTER 2 we have developed reference curves for blood pressure during anesthesia in children. We collected pediatric anesthesia data from 10 different hospitals in two different countries. With 116,362 anesthetic ...
MRI-based Measurement of Structural and Functional Connectivity in Health and Disease

Sinke, Michel Rogier Theodoor (Utrecht University, 2020-07-06)

The mammalian brain can be regarded as a highly complex and integrative network that enables mammalian brain function and behaviour. Therefore it is important to study consequences of brain disorders from a network perspective ...
Tools for quantitative MR imaging and spectroscopy for the improvement of therapy evaluation in oncology

van Houtum, Quincy (Utrecht University, 2020-07-06)

In recent years a paradigm shift in therapy evaluations for oncology is apparent. Focusing on the morphological changes with the variety of imaging modalities is not sufficient to assess therapy efficacy during treatment. ...
Molecular and morphologic study of pancreatic cancer evolution

Noë, Michaël (Utrecht University, 2020-07-08)

Pancreatic cancer has a dismal prognosis. We have studied this cancer through the eyes of Charles Darwin: with the focus on how these tumors arise and evolve. With molecular techniques and analyses from evolution theory, ...
Nutritional challenges in adult patients with cystic fibrosis pre and post lung transplantation

Hollander-Kraaijeveld, Franziska Magdalena (Utrecht University, 2020-07-09)

This thesis aims to increase the knowledge on measuring body composition, caloric demands, and effectiveness of nutritional interventions in people with cystic fibrosis (CF). This contributes to optimal nutritional care ...
From cell to society: Bioengineering auricular cartilage for ear reconstruction

Otto, Iris Anne (Utrecht University, 2020-07-02)

Regenerative medicine strategies have the potential to substitute surgical techniques for reconstruction of auricular malformations in the future. It is possible to generate new tissues in the laboratory, using a combination ...
Posttranslational modifications in the regulation of Growth Hormone Receptor and Jak2

Sedek, Magdalena (Utrecht University, 2012-01-27)

Growth hormone (GH), secreted by pituitary gland, regulates many important processes like growth, carbohydrate and lipid metabolism and immune responses. Growth hormone acts via growth hormone receptor (GHR) that is localised ...
Maximizing research value: adequate reporting and effective (de-)implementation strategies

Heus, Pauline (Utrecht University, 2020-06-30)

The term evidence-based medicine (EBM) refers to the process of integrating research findings (evidence) with clinical expertise and patient preferences in making decisions for individual patients. EBM requires useful ...
Orthopaedic Aspects of Upper Extremity Tumors

Lans, Jonathan (Utrecht University, 2020-04-09)

The PhD thesis “Orthopaedic Aspects of Upper Extremity Tumors” by Jonathan Lans, was completed with research performed at the Department of Orthopaedics at the Massachusetts General Hospital/Harvard Medical School combined ...
Application of modelling and simulation to optimize anticancer treatment of special patient populations

Janssen, Julie Michelle (2020-04-23)

Special patient groups, such as children and pregnant women, are not regularly included in drug development programs. Changes in physiological processes in these patients affect the pharmacokinetics (PK) and pharmacodynamics ...
Quantification of mRNA translation in live cells using single-molecule imaging

Khuperkar, Deepak; Hoek, Tim A.; Sonneveld, Stijn; Verhagen, Bram M.P.; Boersma, Sanne; Tanenbaum, Marvin E. (Springer Nature, 2020-04-01)

mRNA translation is a key step in gene expression. Proper regulation of translation efficiency ensures correct protein expression levels in the cell, which is essential to cell function. Different methods used to study ...
Surgery for Unresectable Stage IIIC and IV Melanoma in the Era of New Systemic Therapy

Blankenstein, Stephanie A; Aarts, Maureen J B; van den Berkmortel, Franchette W P J; Boers-Sonderen, Marye J; van den Eertwegh, Alfons J M; Franken, Margreet G; de Groot, Jan Willem B; Haanen, John B A G; Hospers, Geke A P; Kapiteijn, Ellen; Piersma, Djura; van Rijn, Rozemarijn S; Suijkerbuijk, Karijn P M; Ten Tije, Albert J; van der Veldt, Astrid A M; Vreugdenhil, Gerard; Wouters, Michel W J M; van Akkooi, Alexander C J (Multidisciplinary Digital Publishing Institute (MDPI), 2020-05-07)

Opportunities for surgical treatment in metastatic melanoma patients have re-emerged due to the development of novel systemic therapeutics over the past decade. The aim of this study is to present data on outcomes of surgery ...
Inter-patient variations in flow boundary conditions at middle cerebral artery from 7T PC-MRI and influence on Computational Fluid Dynamics of intracranial aneurysms

Rajabzadeh-Oghaz, Hamidreza; van Ooij, Pim; Veeturi, Sricharan S.; Tutino, Vincent M.; Zwanenburg, Jaco JM; Meng, Hui (Elsevier Limited, 2020-05)

Background: Computational fluid dynamics(CFD) of intracranial aneurysms requires flow boundary conditions(BCs) as inputs. Patient-specific BCs are usually unavailable and substituted by literature-derived generic BCs. ...
Reply to Massimo Valerio, Mark Emberton, and Hashim U. Ahmed's Letter to the Editor re: Henk G. van der Poel, Roderick C.N. van den Bergh, Erik Briers, et al. Focal Therapy in Primary Localised Prostate Cancer: The European Association of Urology Position in 2018. Eur Urol 2018;74:84-91

van der Poel, Henk G; van den Bergh, Roderick C N; Briers, Erik; Cornford, Philip; Govorov, Alex; Henry, Ann M; Lam, Thomas B; Mason, Malcolm D; Rouvière, Olivier; De Santis, Maria; Wiegel, Thomas; Willemse, Peter-Paul M; van Poppel, Hendrik; Mottet, Nicolas (Elsevier, 2019-02)
Study Protocol for the DETECTIVE Study: An International Collaborative Study To Develop Consensus Statements for Deferred Treatment with Curative Intent for Localised Prostate Cancer

Lam, Thomas B L; MacLennan, Steven; Plass, Karin; Willemse, Peter-Paul M; Mason, Malcolm D; Cornford, Philip; Donaldson, James; Davis, Niall F; Dell'Oglio, Paolo; Fankhauser, Christian; Grivas, Nikos; Ingels, Alexandre; Lardas, Michael; Liew, Matthew; Pang, Karl H; Paterson, Catherine; Omar, Muhammad I; Zattoni, Fabio; Buddingh, Karel T; Van den Broeck, Thomas; Cumberbatch, Marcus G; Fossati, Nicola; Gross, Tobias; Moris, Lisa; Schoots, Ivo G; van den Bergh, Roderick C N; Briers, Erik; Fanti, Stefano; De Santis, Maria; Gillessen, Silke; Grummet, Jeremy P; Henry, Ann M; van der Poel, Henk G; van der Kwast, Theodorus H; Rouvière, Olivier; Tilki, Derya; Wiegel, Thomas; N'Dow, James; Van Poppel, Hendrik; Mottet, Nicolas (Elsevier, 2019-04)
False positives in PIRADS (V2) 3, 4, and 5 lesions: relationship with reader experience and zonal location

Stolk, Tineke T; de Jong, Igle Jan; Kwee, Thomas C; Luiting, Henk B; Mahesh, Shekar V K; Doornweerd, Benjamin H J; Willemse, Peter-Paul M; Yakar, Derya (Springer, 2019-03)

PURPOSE: To investigate the effect of reader experience and zonal location on the occurrence of false positives (FPs) in PIRADS (V2) 3, 4, and 5 lesions on multiparametric (MP)-MRI of the prostate. MATERIALS AND METHODS: ...

Now showing items 21401-21420 of 40729