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UMC Repository: Recent submissions

Now showing items 21341-21360 of 40729

The role of the general practitioner in Shared Decision Making for cancer treatment

Noteboom, Eveline Anne (Utrecht University, 2020-10-13)

The increasing number of treatment options for cancer patients creates the opportunity for patients to choose a treatment that best fits their preferences. Patient involvement is key for personalized cancer care and is ...
Surrogate Outcome Markers and Cerebral Haemodynamics in Carotid Interventions

Rots, Marjolijn Lette (Utrecht University, 2020-10-09)

In this thesis, various aspects of diagnostics and treatment for patients with carotid artery disease are described. We mainly focused on how individualized assessments of both procedural risks as well as potential advantages ...
Progress in diagnostic testing and management of idiopathic ventricular fibrillation

Blom, Lennart Johannes (Utrecht University, 2020-10-06)

Despite the progress in diagnostic testing and management of life-threatening arrhythmia's over the last few decades in a small part of the survivors a cause for the arrhythmia remains unknown. This group is known as ...
New strategies for the management of patients with difficult-to-control hypertension

Kleef, Monique Elisabeth Anna Maria van (Utrecht University, 2020-10-07)

Despite the availability of effective pharmacological treatments, at least half of treated hypertensive patients do not achieve blood pressure lowering to <140/90 mmHg and thus remain at increased risk of cardiovascular ...
Optimizing outcomes of patients with systemic sclerosis

Spierings, Julia (2020-10-12)

Despite improved health care standards and better understanding of pathophysiology, systemic sclerosis (SSc) has an increased mortality and high morbidity. Management of SSc can be challenging due to its heterogeneous ...
Uncovering new cardiac biology by the application of novel techniques in the adult heart

Molenaar, Bas (Utrecht University, 2020-10-06)

The heart is a vital organ that pumps blood though the body, thereby supplying the organs with enough oxygen and nutrients. Since the heart has such a crucial function, heart diseases and failure lead to a significant ...
Novel Therapeutic Approaches to Overcome Acquired Resistance to Enzalutamide in Patients with Advanced Prostate Cancer

Schmidt, Keith Thomas (Utrecht University, 2020-10-06)

This thesis addresses the development of novel therapeutic approaches to combat acquired resistance to enzalutamide, a second-generation androgen receptor antagonist (SG-ARA), in patients with advanced prostate cancer. ...
Personalized medicine for patients with advanced cancer. Towards tailored anti-cancer treatment

Ooft, Salo Noël (Utrecht University, 2020-09-29)

The central theme of precision medicine is designing effective therapeutic interventions for individual patients. In the era of countless treatment options and rising healthcare costs, there is a clear and unmet need to ...
Morphometric analyses to study risk factors in thoracic aortic diseases

Belvroy, V.M. (Utrecht University, 2020-09-24)

In this dissertation, two main aortic pathologies, aneurysmal and dissections, can both be treated with thoracic aortic endovascular repair (TEVAR). TEVAR is the treatment of choice, due to a fast recovery period after ...
Exploring the etiology in spontaneous intracerebral hemorrhage

Jolink, Wilmar (Utrecht University, 2020-10-01)

Intracerebral hemorrhage (ICH) is the most deadly stroke subtype with two out of five patients dying within one month and a high morbidity in those surviving the ICH. Spontaneous ICH is non-traumatic hemorrhage caused by ...
Endochondral bone regeneration: Stepping stones towards clinical translation

Longoni, Alessia (Utrecht University, 2020-09-25)

Bone possesses a great regenerative capacity, as the majority of injuries reach resolution through complete healing. Nevertheless, incomplete healing is observed in 10% of all fractures, usually because the size of the ...
IMPLEMENTATION OF INNOVATION AND ETHICS USING VIDEO-BASED LEARNING IN NERVE SURGERY

Yee, Andrew (Utrecht University, 2020-09-24)

An online video-based learning program in nerve surgery was developed in this thesis as an educational framework to (1) translate expertise globally into clinical practice, (2) implement the constant improvements and ...
New insights from the international registry for extracranial carotid artery aneurysms. Perspectives on etiology and follow-up.

van Laarhoven, Constance (Utrecht University, 2020-09-24)

The thesis describes various aspects on how to improve healthcare for patients with aneurysmal disease of the extracranial carotid artery (ECAA). Due to the rarity of these aneurysms, the natural clinical course and risk ...
Technical developments for MR-based electrical property mapping

Gavazzi, Soraya (Utrecht University, 2020-09-25)

The electrical properties of tissues (permittivity and conductivity) regulate the effects of electromagnetic (EM) fields in the human body. Knowledge of the electrical properties (EPs) permits assessing the safety of human ...
Congenital platelet defects. Clinical features and diagnostic tests

Blaauwgeers, Maaike Willemijn (Utrecht University, 2020-10-01)

Congenital platelet defects (CPDs) are rare disorders of primary hemostasis. Clinical characteristics and burden of disease are poorly described. Next to that, the current diagnostic tools lack sensitivity and specificity ...
Technical developments for MR-based electrical property mapping

Gavazzi, Soraya (Utrecht University, 2020-09-25)

The electrical properties of tissues (permittivity and conductivity) regulate the effects of electromagnetic (EM) fields in the human body. Knowledge of the electrical properties (EPs) permits assessing the safety of human ...
HIV & Comorbidity in the era of modern antiretroviral therapy: Heritages of the past & challenges for the future

van Welzen, Berend Joost (Utrecht University, 2020-09-29)

The introduction of combination antiretroviral therapy (cART) has led to a dramatic increase in life expectancy for people living with HIV (PLWH). As a result, the long-term effects of HIV and cART on different organ systems ...
Prognosis, proportionality and preferences: Deciding on continuing or limiting intensive care treatment

Kerckhoffs, Monika Cecilia (Utrecht University, 2020-09-30)

Each year around 80.000 patients are treated in a Dutch Intensive Care Unit (ICU). Although most patients survive, the aftermath can be severe and mortality during and after the ICU remains significant. Therefore, the ...
Quality improvement of biomarker assessment in breast cancer

van Dooijeweert, Carmen (Utrecht University, 2020-09-29)

Breast cancer treatment is largely guided by the results of tumor tissue analyses, i.e. evaluation of so called biomarkers, by pathologists. These biomarkers determine whether the tumor is sensitive to treatment with hormone ...
Cutting edge tools to reveal lineages and epigenetic modifications in single cells

Florescu, Maria (Utrecht University, 2020-09-29)

Every cell in our body has a past, present and future that is coded in biomolecules. The history of a cell can be, for example, encrypted in small changes in the DNA. Once the DNA in a cell is changed, it transfers these ...

Now showing items 21341-21360 of 40729