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Now showing items 21321-21340 of 40729

Partners of patients with acquired brain injury: impact, dyadic relationships and support

Cox, Vincent Cornelis Maria (Utrecht University, 2020-11-10)

Acquired brain injury (ABI), including stroke and traumatic brain injury, can have a major impact on the lives of both patients and their partners. In the Netherlands, approximately 650.000 patients live with permanent ...
Evolution, structure and assembly of basal Transcription Factor II D

Antonova, Simona Vladimirova (Utrecht University, 2020-10-22)

Numerous transcription regulatory players have emerged in order to meet the increasing demand for transcriptional complexity in the eukaryotic branch of life. Being the first member of the pre-initiation complex to engage ...
Individualized prevention in cardiovascular disease and diabetes mellitus: Risk factors, risk prediction, and treatment effects

de Vries, Tamar Irene (Utrecht University, 2020-11-05)

Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality worldwide. Preventive (pharmacological) measures such as cholesterol and blood pressure lowering, or anticoagulants, are a burden on global ...
Tackling the Achilles heel of spondyloarthritis: Is it an autoinflammatory or autoimmune disease?

van Kempen, Tessa (Utrecht University, 2020-10-27)

Spondyloarthritis (SpA) is a chronic inflammatory disease characterized by articular and extra-articular manifestations. SpA encompasses a heterogeneous spectrum of rheumatic diseases and includes, but not exclusively, ...
Mechanisms and evolution of colistin resistance in clinical Enterobacteriaceae

Janssen, Absalom Benjamin (Utrecht University, 2020-11-03)

Colistin is increasingly used as a last resort drug to treat infections with multidrug resistant Gram-negative bacteria. Colistin acts specifically on Gram negative bacteria due to the selective presence of lipopolysaccharides ...
Renal genetics in transition: On the clinical relevancy of genetic testing in renal disease

Snoek, Rozemarijn (Utrecht University, 2020-10-29)

The work in this thesis makes the case for a genetics-first approach in CKD. Though there is a high prevalence of monogenic kidney disease (MGKD), it is underdiagnosed in daily practice. This while an adequate MGKD diagnosis ...
It's all relative: A cross-disorder approach into brain structure, cognition, and familial risk in schizophrenia and bipolar disorder

de Zwarte, Sonja Maria Cornelia (Utrecht University, 2020-10-30)

Schizophrenia and bipolar disorder are two severe psychiatric disorders with shared symptoms and a strong genetic component that is partly shared between the disorders; however, which factors lead to these illnesses is ...
Progress against childhood and young adolescent cancer in the Netherlands since 1990

Reedijk, Ardine Maria Janna (Utrecht University, 2020-10-29)

Progress against childhood and young adolescent cancer in the Netherlands The incidence of childhood cancer is, albeit modestly, increasing worldwide. During the last 50 years 5-year survival of childhood cancer has ...
Causes and consequences of cerebral microinfarcts. Characterizing the “(in)visible” lesion

Ferro, Doeschka Aniek (Utrecht University, 2020-10-27)

Microinfarcts are very small brain infarcts, that have been described in autopsy studies for a number of years. These studies suggest that microinfarcts could play a role in cognitive decline and dementia. For a long time ...
Inflammation, Calcification, and Risk Prediction in Patients with Stable Cardiovascular Disease: Beyond the Scope of Usual Care

van 't Klooster, Cilie Christina (Utrecht University, 2020-10-22)

The number of patients with established cardiovascular disease (CVD) in a chronic phase is growing. Patients with stable CVD are at risk for recurrent cardiovascular events, and also at risk for cancer, due to shared risk ...
Repurposing established drugs for new indications: leflunomide and hydroxychloroquine combination therapy for Sjögren’s syndrome

Heijden, Eefje Hanna Martine van der (Utrecht University, 2020-10-27)

The immunopathology of pSS is characterized by broad immune-activation involving a wide variety of immune cells. Effective therapeutic options are lacking. Considering the complex interplay of involved immune cells, the ...
Connecting vascular inflammation and endothelial dysfunction in the cardio-renal axis

Wesseling, Marian (Utrecht University, 2020-10-20)

Chronic heart failure with gradual stiffening of the heart without a preceding myocardial infarction is more often diagnosed in woman with kidney failure compared to males. Current diagnostic tools and available therapies ...
Molecular profiling and targeting of brain cells and circuits related to energy balance and food reward

Kakava Georgiadou, Nefeli (Utrecht University, 2020-10-20)

In this thesis, we investigated neurons in the brain that are involved in energy balance and motivation using two approaches. With the first approach we used RNA sequencing in order to sequence the transcriptome of cells ...
The role of carriage in the development of healthcare-associated infections with S. aureus and P. aeruginosa

Paling, Fleur (Utrecht University, 2020-10-20)

This thesis discusses two colonizing bacteria which both have the capability to be an innocent bystander as well as an opportunistic pathogen, which are Staphylococcus aureus and Pseudomonas aeruginosa. They can, among ...
Electrical Status Epilepticus in Sleep

van den Munckhof, Bart (Utrecht University, 2020-10-15)

Encephalopathy with electrical status epilepticus in sleep (ESES) is a childhood epilepsy syndrome characterized by near-continuous epileptic activity in sleep and learning or behavioural problems. Children with ESES may ...
A tale of two measurements: protein-DNA interactions and gene expression in single cells. Protein-DNA interactions and gene expression in single cells

Markodimitraki, Corina Maria (Utrecht University, 2020-10-15)

Our bodies are composed of trillions of cells which are the building blocks that cooperate with each other. A neuron has a characteristic tree-like appearance and is specialized in transmitting electrical pulses to signal. ...
Multi-omics dissection of acquired and inherited heart failure

Pei, Jiayi (Utrecht University, 2020-10-15)

The primary aim of this thesis is to investigate the epigenetic and transcriptional changes in diseased hearts using multi-omics approaches, enabling us to better understand the pathological mechanisms underlying the ...
Cartilage Properties Quantified With 7T MRI

Brinkhof, Sander (Utrecht University, 2020-11-12)

Both the younger population with cartilage defects and the elderly population with OA can benefit from proper assessment of their articular cartilage, for which we use 7T MR imaging in this thesis. In order to get new ...
Mosaic Variegated Aneuploidy. Elucidating the molecular causes of constitutional aneuploidy in humans

Wolf, Bas de (Utrecht University, 2020-10-15)

Mosaic Variegated Aneuploidy (MVA) is a rare developmental disorder characterized by a clinically heterogeneous phenotype and the presence of mosaic aneuploidies (predominantly trisomies and monosomies of mostly random ...
Batten Disease - Beyond the Blind Spots

Kuper, Willemijn Fennie Eelkje (Utrecht University, 2020-10-14)

Batten disease (CLN3 disease) represents a major cause of childhood-onset dementia. Despite the current absence of treatment options, (early) recognition is crucial to avoid a diagnostic odyssey and ensure tailored counseling ...

Now showing items 21321-21340 of 40729