Hereditary proximal spinal muscular atrophy (SMA) is a severe hereditary neuromuscular disorder, which usually presents in infancy or (early) childhood. SMA is caused by loss of SMN1 gene function, leading to a deficiency ...

over 2000 genetic mutations that can cause CF, resulting in many phenotypes. Recently new drugs were developed that treat the disease at the origin of the problem; they enhance the function of the Cystic Fibrosis Transmembrane ...

Nano is a prefix derives from the Greek word ‘νᾶνος’, which means ‘drawf’. Nanomedicine is the healthcare application of nanoscale or nanostructure materials. It is an inter-disciplinary field involving chemistry, biology, ...

The lack of effective treatment options has led to a reluctant attitude towards recurrence-focused surveillance for early detection of pancreatic ductal adenocarcinoma (PDAC) recurrence in most pancreatic cancer clinicians. ...

It was the aim of this thesis to bioengineer a hierarchical vascular supply for the application of pre-vascularized osteogenic tissues that are readily perfusable upon implantation. To this end, we were inspired by the ...

The treatment of advanced rectal cancer has been subjected to many changes in recent years. Diagnostics has improved and the number of treatment options has been expanded. The current neoadjuvant treatment consists of ...

In the quest for new treatments for (osteo)chondral defects and to eliminate or postpone total knee replacement surgery, the potential of 3D bioprinting of (osteo)chondral implants as a surgical procedure has been explored. ...

In order to achieve the Sustainable Development Goals on maternal mortality, it is crucial to implement the maternal death surveillance and response (MDSR) cycle in Suriname. Our nationwide research focussed on the prevalence, ...

Chlamydia is a sexually transmitted infection (STI) and can cause long-term complications, such as subfertility. Therefore, prevention of chlamydia is important, for example through condom use. Whether people use condoms ...