Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

Now showing items 21241-21260 of 40729

Management of patients with shoulder pain in primary care : A pause for reflection

Kooijman, Margit Kirsten (Utrecht University, 2021-03-18)

Why a pause for reflection? Shoulder pain is one of the most common musculoskeletal disorders. In recent years, much research has been done to improve the diagnosis and treatment of patients with shoulder pain. However, ...
Neurorehabilitation for upper limb recovery after stroke : The use of non-invasive brain stimulation

Lieshout, Eline Christine Catharine van (Utrecht University, 2021-03-23)

Although the treatment options for a stroke (cerebral infarction or cerebral haemorrhage) have greatly improved in recent years, about half of the patients suffer from reduced arm function in the long term. The impact on ...
A pan-European perspective on food allergy : prevalence, predictors and patient profiles

Lyons, Sarah Anne (Utrecht University, 2021-03-11)

The largest study to investigate food allergy across Europe reveals that food allergy is common: the prevalence ranges from 0.3% in Greek adults to as high as 6% in Polish children and Swiss adults, with prevalence estimates ...
INVESTIGATIONS ON EPITHELIAL BIOLOGY USING ORGANOID DIFFERENTIATION AND CO-CULTURES : Building representative models of the snake venom gland and complex tissue interactions in cancer and metabolic diseases

Puschhof, Jens (Utrecht University, 2021-03-09)

The work described in this thesis revolves around one question: How can we utilize and develop organoid technology to elucidate previously intractable areas of biology? My approaches to this question in the various chapters ...
Brain temperature of infants with neonatal encephalopathy following perinatal asphyxia calculated using magnetic resonance spectroscopy

Annink, Kim V.; Groenendaal, Floris; Cohen, Daan; Aa, Niek E. van der; Alderliesten, Thomas; Dudink, Jeroen; Benders, Manon J. N. L.; Wijnen, Jannie P. (Springer Nature, 2020-01)

Background: Little is known about brain temperature of neonates during MRI. Brain temperature can be estimated non-invasively with proton Magnetic Resonance Spectroscopy ( 1H-MRS), but the most accurate 1H-MRS method has ...
The long-term effect of perinatal asphyxia on hippocampal volumes

Annink, Kim V.; Vries, Linda S. de; Groenendaal, Floris; Heuvel, Martijn P. van den; Haren, Neeltje E.M. van; Swaab, Hanna; Handel, Mariëlle van; Jongmans, Marian J.; Benders, Manon J.; Aa, Niek E. van der (Springer Nature, 2019)

Background: Hypoxic-ischemic encephalopathy (HIE) in term-born infants can lead to memory problems. The hippocampus is important for long-term episodic memory. The primary aim was to investigate the effect of HIE on ...
Cerebellar injury in term neonates with hypoxic–ischemic encephalopathy is underestimated

Annink, Kim V.; Meerts, Lilly; Aa, Niek E. van der; Alderliesten, Thomas; Nikkels, Peter G. J.; Nijboer, Cora H. A.; Groenendaal, Floris; Vries, Linda S. de; Benders, Manon J. N. L.; Hoebeek, Freek E.; Dudink, Jeroen (Springer Nature, 2021-04)

BACKGROUND: Postmortem examinations frequently show cerebellar injury in infants with severe hypoxic–ischemic encephalopathy (HIE), while it is less well visible on MRI. The primary aim was to investigate the correlation ...
Allopurinol: Old Drug, New Indication in Neonates?

Annink, Kim V.; Franz, Axel R.; Derks, Jan B.; Rüdiger, Mario; Bel, Frank van; Benders, Manon J. N. L. (Bentham Science Publishers, 2017-10-01)

Background: Hypoxic-ischemic encephalopathy (HIE) is an important cause of neonatal mortality and neurological morbidity, even despite hypothermia treatment. Neuronal damage in these infants is partly caused by the ...
Introduction of Ultra-High-Field MR Imaging in Infants : Preparations and Feasibility

Annink, K. V; Aa, N. E. van der; Dudink, J.; Alderliesten, T.; Groenendaal, F.; Lequin, M.; Jansen, F.E.; Rhebergen, K. S.; Luijten, P.; Hendrikse, J.; Hoogduin, H. J. M.; Huijing, E. R.; Versteeg, E.; Visser, F.; Raaijmakers, A. J. E.; Wiegers, E.C.; Klomp, D. W. J.; Wijnen, J. P.; Benders, M. J. N. L. (American Society of Neuroradiology, 2020-08)

Background and purpose: Cerebral MR imaging in infants is usually performed with a field strength of up to 3T. In adults, a growing number of studies have shown added diagnostic value of 7T MR imaging. 7T MR imaging might ...
Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO) : study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)

Maiwald, Christian A.; Annink, Kim V.; Rüdiger, Mario; Benders, Manon J. N. L.; Bel, Frank van; Allegaert, Karel; Naulaers, Gunnar; Bassler, Dirk; Klebermaß-Schrehof, Katrin; Vento, Maximo; Guimarães, Hercilia; Stiris, Tom; Cattarossi, Luigi; Metsäranta, Marjo; Vanhatalo, Sampsa; Mazela, Jan; Metsvaht, Tuuli; Jacobs, Yannique; Franz, Axel R.; ALBINO Study Group (BMC, 2019-06-27)

BACKGROUND: Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death and long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE in Europe and even ...
The development and validation of a cerebral ultrasound scoring system for infants with hypoxic-ischaemic encephalopathy

Annink, Kim; Vries, Linda de; Groenendaal, Floris; Vijlbrief, Daniel; Weeke, Lauren; Roehr, Charles; Lequin, Maarten; Reiss, Irwin K M; Govaert, Paul; Benders, Manon; Dudink, Jeroen (Springer Nature, 2020-03)

BACKGROUND: Hypoxic-ischaemic encephalopathy (HIE) is an important cause of morbidity and mortality in neonates. When the gold standard MRI is not feasible, cerebral ultrasound (CUS) might offer an alternative. In this ...
Patient outcome after cerebrovascular interventions : Perioperative respiratory and cardiovascular management

Akkermans, Annemarie (Utrecht University, 2021-03-11)

Although cerebrovascular interventions aim to improve long-term neurologic outcome, these procedures are accompanied by a risk of perioperative cerebral hypoperfusion and ischemia. This thesis explored several approaches ...
Improvement of in vitro food allergy diagnostics by identifying unique antibody traits

Ehlers, Anna Maria (Utrecht University, 2021-02-18)

Food allergy is a major health concern, which affects around 3% of the Western population. The backbone of food allergy management is still comprised of emergency treatment prescription and food restrictions. To avoid ...
Antiepileptic drug withdrawal

Lamberink, Herman Jan (Utrecht University, 2019-10-15)

Epilepsy is a disorder characterized by recurrent epileptic seizures. Antiepileptic drugs are successful in preventing seizures for the majority of patients. When a person with epilepsy is seizure-free, drugs can be stopped ...
The Many Faces of Gene Regulation: Extrinsic Control of Cell Fate and Function

Sporrij, Audrey (Utrecht University, 2021-03-30)

Cell fate and function is determined by the complex interplay between extrinsic and intrinsic factors. Environmental signals play important roles in the processes that underlie cell behavior. All cells have the ability to ...
Lost in transition? Immune regulatory mechanisms in early life

Hoeks - de Gruijter, Sanne Birgit Elisabeth Anne (Utrecht University, 2021-03-18)

Fetal life and early infancy are recognized as a critical period to shape the immune system for life. Slowly the neonatal immune system changes its regulatory responses into effector responses. Genes, environmental factors ...
Self-management support using mHealth in patients with COPD: From promise to proof

Korpershoek, Yvonne Johanna Gerarda (Utrecht University, 2021-03-04)

Patients with Chronic Obstructive Pulmonary Disease (COPD) can experience periods of symptom deterioration called exacerbations. Self-management is important to reduce the negative impact of these exacerbations and requires ...
A Safer Care Pathway from ICU to Home: With wearable & wireless monitoring

Breteler, Martine Josefien Maria (Utrecht University, 2021-02-04)

Changes in vital signs are often the first sign of patient deterioration and the need for escalation of care. Unfortunately, vital signs are typically recorded not more than every 4-8 hours as the current standard on ...
Frailty and postoperative functional outcome Preoperative evaluation in elderly cardiac surgery patients: Preoperative evaluation in elderly cardiac surgery patients

Verwijmeren, Lisa (Utrecht University, 2021-01-19)

Patients presenting for cardiac surgery are ageing. Older patients often have multiple chronic diseases and may be frail. Frailty is a biological syndrome characterised by a loss of functional reserves across multiple organ ...
Fatigability in spinal muscular atrophy : quantification, characterization and treatment

Bartels, Bart (Utrecht University, 2020-09-03)

Fatigability is frequently mentioned and considered as a highly debilitating impairment of daily life by many patients with SMA, but has nevertheless been given little priority for a long time. Until recently, clinical ...

Now showing items 21241-21260 of 40729