Prediction models are a valuable tool in medical practice, as they can help in diagnosis and prognosis. In diagnosis they can be used to calculate the most likely disease or other health status for a patient. In prognosis ...

Aneurysmal subarachnoid hemorrhage (SAH) can lead to poor functional outcome and cognitive impairment. The most important determinant of poor functional outcome after aneurysmal SAH is early brain injury, which is directly ...

Pharmacotherapy is an essential element of primary care. Generally, medication is very effective. Yet, medication can also cause harm. Especially elderly patients using multiple medications are at risk of such medication-related ...

In this thesis the potential of immune monitoring before and after stem cell transplantation in pediatric patients is described. As each patient is unique, it is often unknown how the immune system will respond to medication ...

Part I is an introduction on the rehabilitation of single-sided deafness (SSD). In the first literature review, the current treatment options for SSD are discussed: bone conduction devices (BCD) and contralateral routing ...

In this thesis the trend over the last two decades of improved survival after a first hospitalisation for heart failure is shown in the Netherlands for both men and women. Furthermore it is shown that there is a relation ...

Organoid technology is an emerging new model system that enables to closely capture and study the physiology and properties of the epithelial tissues “in a dish”. The model relies on the presence of stem cell pools within ...

This thesis addresses a major challenge in head and neck surgical oncology; detection of lymphatic metastasis in patients with early stage oral cancer. The sentinel lymph node biopsy (SLNB) procedure has been introduced ...

In the Dutch breast cancer screening program, all women aged 50 to 75 years are invited for mammography screening biennially. Yearly, approximately 1 million screening examinations are performed in the screening ...

This thesis investigates the effects of uveitis on the function of the retina using the electroretinogram (ERG). Uveitis comprises a group of diseases with an inflammation in the eye. Uveitis can usually be treated, but ...