Abstract
Background: Hypoxic-ischemic encephalopathy (HIE) is an important cause of neonatal mortality and
neurological morbidity, even despite hypothermia treatment. Neuronal damage in these infants is partly caused by
the production of superoxides via the xanthine-oxidase pathway and concomitant free radical formation. Allopurinol is a xanthine-oxidase inhibitor and can potentially reduce the formation of
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