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Otorhinolaryngologic manifestations of 22q11.2 deletion syndrome

Verheij, Emmy (Utrecht University, 2021-10-28)

22q11.2 deletion syndrome (22q11DS) is caused by a microdeletion on chromosome 22. It occurs in approximately 1:3000-6000 live births. The aim of this thesis was to give an overview of otorhinolaryngologic manifestations ...
Differential susceptibility to rearing conditions in mice

Knop, Jelle (Utrecht University, 2021-10-26)

The research presented in this thesis is the result of our efforts to study differential susceptibility in an animal model. By exposing heterozygous MR or Drd4 knock-out mice and control litter mates to negative, neutral ...
Quantitative MRI of physiological brain tissue deformation in humans

Sloots, Jacob Jan (Utrecht University, 2021-10-26)

The objective of the work presented in this thesis was to develop non-invasive imaging techniques of brain pulsations in response to the beating heart and respiration, in order to pave the way to non-invasive, in-vivo ...
Gene expression in sight: Single-molecule studies of gene expression control

Sonneveld, Stijn (Utrecht University, 2021-11-03)

Humans are multicellulair organisms, which means that the human body consists out of many individual cells. On average, the human body comprises an astounding number of 20 to 30 trillion cells. These cells are not all the ...
Optimizing Inguinal Hernia Surgery

Bakker, Wouter Jesse (Utrecht University, 2021-09-30)

The aim of this thesis has not just been to expose problems, obstacles, or lacking consensus, but to provide pragmatic solutions and recommendations to optimize inguinal hernia surgery. This thesis focusses on three ...
Case-finding in Multiple Endocrine Neoplasia: clues for a timely diagnosis

Broek, Medard Franciscus Maria van den (Utrecht University, 2021-11-11)

Multiple Endocrine Neoplasia (MEN) syndromes are rare, hereditary diseases, predisposing to the development of tumors in multiple endocrine organs and several non-endocrine features. Four distinct syndromes can be distinguished ...
Neoadjuvant single-dose irradiation in low-risk breast cancer

Vasmel, Jeanine Else (Utrecht University, 2021-10-28)

The aim of this thesis is to assess whether single-dose partial breast irradiation before surgery could be used as a safe and effective treatment for low-risk breast cancer patients. The majority of low-risk breast cancer ...
Structural variation in genomes and its role in disease

Vlaar, Judith Maria (Utrecht University, 2021-10-21)

Technological advances in DNA sequencing techniques provide new resources and opportunities to study genetic contributions to disease. Still, it remains a challenge to determine which of the many detected genetic changes ...
From Derailed Development to Childhood Cancer : Using organoid models to study Malignant Rhabdoid Tumors

Custers, Lars Martinus Catherina (Utrecht University, 2021-10-15)

Further improvement in the survival of children with cancer is likely to come from therapies specifically designed to target the unique oncogenic properties of childhood cancer cells. A pediatric malignancy for which ...
Sympathetic nerves: novel therapeutic targets in the treatment of inflammatory disease? : An anatomical study on sympathetic innervation of the human spleen, milky spots, lymph nodes and dorsal root ganglia

Cleypool, Cindy Gerritje Johanna (Utrecht University, 2021-10-05)

Animal studies have demonstrated that various secondary lymphoid organs (including the spleen and lymph nodes) are sympathetically innervated and that these nerves play a crucial role in regulation of immune cell activity ...
Psychotropic medication use in the Armed Forces: prescription patterns and treatment after trauma

Knotnerus-Janssen, Debbie Gerda An (Utrecht University, 2021-09-28)

What are the trends in the use of psychotropic medication by Dutch soldiers? This is the central question in this thesis in which the characteristics of psychotropic medication use within the Dutch Armed Forces and in a ...
Outcome of long-term mechanical circulatory support : Quod bonum, faustum felixque est

Felix, Susanne Elisabeth Agnes (Utrecht University, 2021-09-23)

In patients with advanced systolic heart failure, heart transplantation or durable mechanical circulatory support (MCS) may be considered. Initially, MCS was only implanted as a bridge to heart transplantation. As a ...
Towards personalized treatment of clozapine

Okhuijsen-Pfeifer, Cynthia (Utrecht University, 2021-10-07)

The aim of this thesis was to find potential factors associated with side effects and efficacy that could be used in clinical practice to personalize clozapine treatment. In this chapter, the main findings from the performed ...
The multifunctional role of Semaphorin6A during brain development and disease: Moving forward with reverse signaling

Verhagen, Marieke Geerte (Utrecht University, 2021-10-14)

The brain is a complex and versatile organ that undergoes various phases of development. This thesis focuses on the moment when neurons migrate from their birthplace to different brain areas and start to make connections ...
Beyond the diagnosis: a PROactive approach to fatigue, daily life participation, and health-related quality of life in paediatric chronic disease

Nap-van der Vlist, Merel Marlena (Utrecht University, 2021-09-14)

More than one in five children with a chronic disease, such as cystic fibrosis, an autoimmune disease, or children after the treatment of childhood cancer, reports severe fatigue. This is four times as much as children in ...
Patient profiling and prediction of response to immune-modulating treatment in moderate-to-severe atopic dermatitis

Bakker, Daphne Suzanna (Utrecht University, 2021-09-28)

Atopic dermatitis (AD) is one of the most common chronic inflammatory skin diseases worldwide. Due to new targeted treatments that are being developed, the treatment of AD will move towards an era of more personalized ...
Epidemiology of antimicrobial-resistant bacteria in food and humans

Huizinga, Pepijn (Utrecht University, 2021-09-21)

This thesis describes different aspects around the central topic if food could be a source of resistant bacteria for humans. Extended-spectrum beta-lactamase-producing E. coli (ESBL-EC) are bacteria that are resistant to ...
Microbiome and Inflammation in Antibody Deficiency

Berbers, Roos-Marijn (Utrecht University, 2021-09-21)

Common variable immunodeficiency (CVID) is an immune deficiency that not only causes increased susceptibility to infection, but also to inflammatory complications such as autoimmunity, lymphoid proliferation, cancer and ...
Novel biomarkers for sickle cell disease and other hereditary hemolytic anemias

Rab, Minke Ariena Elisabeth (Utrecht University, 2021-09-29)

The aim of this thesis was to develop and validate new biomarkers in hereditary hemolytic anemia. A new application of ektacytometry, so called oxygen gradient ektacytometry, that characterizes red cell sickling, is described ...
Characterizing early blood-induced joint damage : towards new treatment modalities of hemophilic arthropathy

Pulles, Astrid Elisabeth (Utrecht University, 2021-09-23)

Musculoskeletal bleeding is the hallmark of hemophilia and cannot be completely prevented despite clotting factor prophylaxis. Blood in the joint results in synovial inflammation, cartilage degeneration and bone remodelling. ...

Now showing items 21141-21160 of 40729