Systemic sclerosis (SSc) is an autoimmune rheumatic disease characterized by vasculopathy, inflammation and fibrosis of the skin and internal organs. The aetiology of SSc is largely unknown, and its pathogenesis is complex ...

During life, the DNA of our cells is constantly damaged by various exposures. These exposures can be both cell-intrinsic, or originate outside the body, such as sunlight or chemotherapy. DNA-damage in a healthy cell can ...

In this thesis, we elucidate the important role of mathematical models for infectious disease control with a focus on the transmission of SARS-CoV-2 in the community and in hospital settings, as well as the transmission ...

Bacteria live all around us and in general they live peacefully in balance with us. Sometimes however this balance is disrupted when a bacteria starts to adapt and explore new areas. This is also the case for the gut ...

The heart has one task: circulating blood throughout our bodies. An adequate circulation is essential for making sure all parts of our bodies receive enough oxygen and nutrients. This, in turn, is required for our health ...

The built environment is associated with various environmental exposures such as air pollution, noise, and fast-food outlets. In this thesis, we use environmental data at fine resolution and we integrate time-activity ...

1. The occurrence of neurocognitive deficits in diffuse glioma Treatment-naive glioma patients Cognitive impairments occur in the large majority of glioma patients. Because neurocognitive functioning (NCF) in glioma ...

This thesis describes the introduction of a new method for bedside analysis of innate immune cells in health and disease. Flow cytometry is an analysis method, that is almost 50 years old and has been extensively used in ...

Osteoarthritis (OA) is a debilitating disease that causes a giant socioeconomic burden. Until now, there is no drug to limit disease progression. There are important steps towards a drug for OA. First, we need to be able ...

The unconventional γδT cells share the property of innate and adaptive immunity that allows recognition of infected, stress-induced, and malignantly-transformed cells and undergo clonal expansion and memory formation. γδT ...