This thesis describes various projects focusing on the development of live-cell single-molecule imaging assays to grasp dynamic processes. Chapter 2 and 3 focus on heterogeneity of translation on single mRNAs over time. ...

Sleep problems are common in children with Cerebral Palsy (CP), and can greatly impact on the health and functioning of the child. Health-promotion strategies and goals for rehabilitation programs for children with CP have ...

The biological differences between males and females encompass different sex chromosomes and differing sex hormones. These differences contribute to sex differences in the development of disease. Typical examples are the ...

During the development of the brain, different types of neuronal and non-neuronal cell types are formed. These cells migrate through the developing brain to arrive at their final location. In addition, they send out axons ...

The treatment of cancer is increasingly personalized, with dose optimization being an important factor. In this thesis, a number of factors is studied to determine how these factors can be used to optimize the dose. First, ...

Nearly 98 - 99% of the genome has little to no coding function and it is transcribed into non-coding RNAs (ncRNAs). These influence transcription, RNA processing and translation and include different sorts of molecules ...

Renal tumors account for ~5% of all childhood cancer diagnoses. Among them, Wilms tumor is by far the most common. In this thesis, we investigated which factors play a role in the development and treatment of childhood ...

Osteoarthritis is a progressive degenerative joint disease. There is increasing evidence that osteoarthritis is a disease of the whole joint, including multiple joint tissues, with an important role for synovial inflammation. ...

Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a hereditary heart muscle disease, characterized by fibrofatty replacement of predominantly the right ventricle (RV). ARVC is one of the major causes of sudden ...