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UMC Repository: Recent submissions

  • Skin immunity in protection against Staphylococcus aureus infections 
    Mnich, Malgorzata Ewa (Utrecht University, 2022-01-12)
    Gram-positive bacterium Staphylococcus aureus is a common member of the human microbiome colonizing up to 30% of the population. Mostly residing in the nares and on the skin S. aureus is a leading cause of surgical site ...
  • Improving allergenicity risk assessment of novel foods 
    Smits, Marcus Wilhelmus (Utrecht University, 2022-01-19)
    Both protein consumption and the world’s population are increasing, which leads to an urgent demand for new sustainable food protein sources. However, introduction of novel protein sources is not without risk. Novel protein ...
  • How staphylococcal protein A blocks IgG effector functions: A golden way to evade phagocytosis 
    Queiroz da Cruz, Ana Rita (Utrecht University, 2022-01-13)
    Antibiotic resistance is a major problem for public health. Staphylococcus aureus, commonly known as “multi-drug resistant bacterium” or simply as “super bug”, is one of the pathogens for which new antibiotics and other ...
  • Locally Advanced Pancreatic Cancer: Exploring treatment strategies 
    Walma, Marieke Suzanne (Utrecht University, 2022-01-13)
    With a worldwide incidence of approximately 496,000 new cases and 466,000 deaths in 2020, pancreatic cancer is among the most deadliest of cancers. The majority of patients present with an advanced stage of cancer at ...
  • Traumatic Rib Fractures: Epidemiology, Treatment and Outcome 
    Peek, Jesse (Utrecht University, 2021-07-08)
    Rib fractures are still a relevant and frequently occurring injury associated with a significant morbidity and mortality. Six percent of all hospitalized trauma patients appeared to sustain one or more fractured ribs and ...
  • Bittersweet memories: Immunity against Staphylococcus aureus wall teichoic acid 
    Hendriks, Astrid (Utrecht University, 2022-01-12)
    Staphylococcus aureus is a leading cause of bacterial infections, including superficial skin infections and bacteremia, which occur both inside and outside the hospital. The emergence of antibiotic-resistant S. aureus ...
  • Digital health in obstetric care 
    Heuvel, Josephus Fransiscus Maria van den (Utrecht University, 2021-06-22)
    Around 10% of pregnancies in the Netherlands are complicated by different obstetric complications. Follow up of these pregnancies need extra surveillance with weekly visits or antenatal hospital admission. This thesis ...
  • Brain morphology, survival and patient-reported outcomes after cranial radiotherapy 
    Nagtegaal, Steven Hermanus Johannes (Utrecht University, 2022-01-27)
    Survival after cancer treatment is continuously improving due to new medication, surgery techniques and technological innovation. This forces us to consider long-term effects of treatment, that might be detrimental to a ...
  • Reno-cardiovascular disease and regeneration: focus on interactions with the immune system 
    Krebber, Merle Meis (Utrecht University, 2022-01-11)
    Reno-cardiovascular diseases (reno-CVD) are characterized by a vicious cycle of injury to the kidneys, heart and blood vessels. Risk factors for CVD, including kidney disease and obesity, probably lead to similar disease ...
  • Gene re-activation mechanisms in the context of acquired drug resistance 
    González Manjón, Anna (Utrecht University, 2022-01-13)
    In this thesis we aim to better understand the molecular mechanisms that cells employ to upregulate genes undergoing chemotherapeutic drug treatments. We use the ABCB1 gene as our model gene to study this process as its ...
  • Prediction in cutaneous melanomas : A multicontinental approach 
    Sharouni, Mary-Ann el (Utrecht University, 2022-01-25)
    This thesis is a collaboration between the University Medical Center Utrecht and Melanoma Institute Australia, Sydney, Australia. One in 5 Dutch people will get diagnosed with skin cancer in their life. In 10% of cases ...
  • Promoting inpatients' physical activity : From the development of a family participation intervention to the implementation of a multidimensional action plan 
    Delft, Lotte Martine Maria van (Utrecht University, 2022-02-17)
    In order to prevent physical decline it is necessary that patients remain physically active as much as possible during hospitalization. In this thesis, two intervention projects aiming to increase physical activity in ...
  • Improving outcomes for patients with necrotizing soft tissue infections 
    Nawijn, Femke (Utrecht University, 2022-01-18)
    Necrotizing soft tissue infections (NSTIs) are lethal and rare infections of the soft tissues, which are especially notorious for their rapid spreading nature and sometimes mutilating surgeries, consisting of resecting all ...
  • Intracranial aneurysms : family history and risk of rupture 
    Zuurbier, Charlotte Catharina Maria (Utrecht University, 2021-12-21)
    Intracranial aneurysms are acquired dilations of the arteries in the brain. Approximately 3% of the adult population has an intracranial aneurysm. When an intracranial aneurysm bursts (this is also called rupture) this ...
  • Born just a few weeks early… is this relevant? : Insights into brain lesions, brain growth, and outcome in moderate-late preterm infants 
    Boswinkel, Vivian (Utrecht University, 2021-12-09)
    This thesis gives insights into neonatal brain injury, brain growth and neurodevelopmental outcome in moderate-late preterm (MLPT) infants, born at 32–36 weeks’ gestation. Additionally, we describe the neurodevelopmental ...
  • Biomarkers of Frailty: Explorative research with a multi-domain approach 
    Rietman, Maaike Liset (Utrecht University, 2021-12-16)
    Frailty is an age-associated syndrome and can be described as a state of increased vulnerability to adverse health outcomes when exposed to stressors (e.g. an infection), caused by the cumulative decline in one or more ...
  • Thoughts on dysnatremia 
    Voets, Philippus Johannes Gerdiaan Maria (Utrecht University, 2021-12-23)
    Osmoregulation is the result of the complex interplay of several physiological processes, which control the water fluxes in the human body. A concise overview is presented in Chapter 1. The plasma sodium concentration is ...
  • Protective and pathological remodeling in cardiac disease 
    Kohela, Arwa Obada Abdelrahman Reda (Utrecht University, 2022-01-11)
    Cardiovascular disease (CVD) is the leading cause of death worldwide. During disease progression, the heart undergoes changes in its size, shape, structure and function referred to as cardiac remodeling. These changes can ...
  • De sCepsis voorbij : oratie 
    Cremer, Olaf (UMC Utrecht, 2021-11-05)
    We spreken van sepsis wanneer de afweerreactie tegen een infectie zo hevig en ongecontroleerd verloopt dat het lichaam schade toebrengt aan de eigen weefsels en organen. Patiënten worden hierdoor levensbedreigend ziek en ...
  • A Culture Change in Geriatric Traumatology 
    Schuijt, Henk Jan (Utrecht University, 2021-12-14)
    To design and consolidate a more patient-tailored approach for geriatric fracture patients will require a culture change. The author proposes to regard falls and subsequent fractures in geriatric patients not just as a ...