Redox signaling is crucial for cells to maintain homeostasis. The goal of this research is to understand the molecular mechanisms that underlie redox signal propagation and how changes in the cellular redox state affect ...

This thesis focusses on cognitive decline in HIV infection, of which the different forms are summarized under the term HIV-Associated Neurocognitive Disorder (HAND). The different parts of the thesis discuss separate aspects ...

Immunotherapy has been considered a breakthrough in cancer treatment in the past decade. Immune checkpoint inhibitors and Chimeric Antigen Receptor T cells (CAR-T cells) have entered clinical practice and achieved promising ...

Moderate and severe traumatic brain injury are a common cause of death and disability in the Netherlands and pose a threat, much bigger than exsanguination and multi-organ failure, for our isolated TBI and multiple injured ...

Worldwide 3.5 million patients receive dialysis treatment of which 89% is treated with hemodialysis (HD) and 11% with peritoneal dialysis (PD). Although life sustaining, existing dialysis techniques have major shortcomings. ...

T-cell acute lymphoblastic leukemia (T-ALL) is a rare hematologic malignancy which yearly affects around 15-20 children in the Netherlands (SKION database). Resistance to steroid treatment (i.e. prednisolone and dexamethasone) ...

Arrhythmogenic cardiomyopathy (ACM) is an inherited myocardial disease which is characterized by fibrofatty replacement of the myocardial tissue and pre-dominantly, but not exclusively, affects the epicardial side of the ...

Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by progressive muscle weakness and is the leading genetic cause of infant death and disability in childhood. Its prognosis is now being altered by ...

Organoid research is currently rapidly emerging as a valuable tool for numerous applications in biomedicine. These developments are well-aligned with the current broader movement aimed at tailoring healthcare to the specific ...