This thesis aimed to better understand the function and relevance of the GFAP protein in glioma biology. We have shown that GFAP plays a dual role in glioma cell invasion. First of all, we show that GFAP isoforms distinctively ...

Native SERPINs are currently the treatment of choice for diseases driven by excessive serine protease activity. Nonetheless, their lack of specificity and potency as well as the short half-life of their recombinant ...

The first part of this thesis focused on the individual perspective of healthy and sustainable diets. Here, we investigated the association between adherence to various healthy and/or sustainable dietary patterns in relation ...

Arrhythmogenic cardiomyopathy (ACM) is a genetic cardiomyopathy which is characterized by progressive fibro-fatty replacement of the myocardium. Clinically, this disease may lead to life-threatening arrhythmias and heart ...

Achieving an appropriate individualization of treatment in older patients with cancer remains challenging. Identifying someone’s frailty is an important aspect to guide treatment decisions. Frailty can be identified by ...

Fat tissue is more than just fat cells that store lipids. It is a highly complex tissue with a large variety of different cells that have different functions both locally and throughout the whole body. Fat cells for example, ...

In prostate cancer, aberrant androgen receptor (AR) function leads to the deregulation of AR target gene expression, driving prostate tumorigenesis. AR-directed therapies are transiently effective, and resistance to ...

This Ph.D. thesis, ‘Spontaneous cerebellar intracerebral haemorrhage: treatment and long-term outcome’, described clinical research on associations between haematoma evacuation and outcome in patients with spontaneous ...

This thesis aimed to investigate the clinical applicability of liquid biopsy circulating tumor DNA (ctDNA) in the disease management of patients with metastatic colorectal cancer (mCRC). The results from this thesis have ...

Background Systemic sclerosis (SSc) is a rare autoimmune disease in which the connective tissue in the skin and internal organs of patients thickens and hardens due to the excessive production of extracellular matrix ...