Brain-computer interfaces (BCI) have the potential to improve and enhance our lives, enabling us to control devices with our thoughts and intentions. Currently, BCIs primarily aim to benefit a small patient population by, ...

This thesis evaluated the application of MRI guidance in different steps of the breast cancer radiotherapy workflow and describes how to handle several challenges for MRI-guided radiotherapy. The application of MRI is most ...

The MR-linac combines an MRI scanner with a radiotherapy treatment device and enables the visualization of a patient’s anatomy while the treatment is delivered (MRI-guided radiotherapy). However, MRI receive arrays, which ...

Spinal fusion surgery is an established treatment for various spinal disorders, like deformities, fractures and degenerative diseases. Two or more vertebrae are connected with implants for stabilization. Mostly a bone graft ...

Articular cartilage is the white, shiny layer that covers the ends of long bones and absorbs weight and shocks. As a result, the joint moves smoothly and without pain. Damage to articular cartilage is a common problem that ...

Multiple endocrine neoplasia type 1 (MEN) is a rare tumor syndrome leading to multiple neuroendocrine tumors in the duodenum and pancreas already at a young age. These tumors are the leading cause of death and can secrete ...

Actively self-renewing tissues need to maintain a delicate balance between providing sufficient cells to maintain the integrity of a tissue and preventing excessive proliferation resulting in tumorigenesis. Consequently, ...

In the current era of precision medicine in oncology, the tailoring of treatment of patients on the (molecular) characteristics of the tumor is widely performed. However, for many drugs, the full spectrum of precision ...

To better understand cardiovascular diseases, patient data from the electronic health record can be used in research. In this thesis, I captured these data manually in clinical registries and developed a research data ...

Anticoagulation is the cornerstone of treatment for venous thromboembolism (VTE; deep vein thrombosis and pulmonary embolism). After an initial treatment of at least 3 months, a decision must be made to stop treatment or ...