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Now showing items 20921-20940 of 40729

Enhancing quality in translation research - learning from experiences in cardiac repair

Naald, Mira van der (Utrecht University, 2022-09-27)

Medical research aims to find new treatments for human diseases. Despite researchers dedication and integrity, researchers preconceived views can influence their judgement, causing suboptimal research and limiting the value ...
Correction to: A Landscape Analysis of Post-Marketing Studies Registered in the EU PAS Register and ClinicalTrials.gov Focusing on Pregnancy Outcomes or Breastfeeding Effects: A Contribution from the ConcePTION Project

Roque Pereira, Leonardo; Durán, Carlos E; Layton, Deborah; Poulentzas, Georgios; Lalagkas, Panagiotis-Nikolaos; Kontogiorgis, Christos; Sturkenboom, Miriam (Springer, 2022-04)

Correction to: Drug Safety https://doi.org/10.1007/s40264-022-01154-7
A Landscape Analysis of Post-Marketing Studies Registered in the EU PAS Register and ClinicalTrials.gov Focusing on Pregnancy Outcomes or Breastfeeding Effects: A Contribution from the ConcePTION Project

Roque Pereira, Leonardo; Durán, Carlos E; Layton, Deborah; Poulentzas, Georgios; Lalagkas, Panagiotis-Nikolaos; Kontogiorgis, Christos; Sturkenboom, Miriam (Springer, 2022-04)

INTRODUCTION: A large proportion of medicine product labels lack information on safety in pregnancy and breastfeeding. To address this gap, pharmaceutical companies are requested to develop post-approval studies regarding ...
Using Novel Precision Medicine Tools to Identify Variability in Hematopoietic Cell Transplantation

McCune, Jeannine Sue (Utrecht University, 2022-10-04)

In cancer patients, chemotherapy can be personalized based on the characteristics of the tumor and the patient. This thesis focuses on using patient characteristics to personalize an old chemotherapy drug, specifically ...
The effect of head and neck cancer on the oral food process: Deficits in mastication, salivary flow, and swallowing

Vermaire, Jorine Ariane (Utrecht University, 2022-10-10)

This thesis addresses main complications that may occur after treatment for head and neck cancer; xerostomia, dysphagia and masticatory deficits. As stated in the introduction of this thesis, there are many different steps ...
A panoramic view of the phenotypic landscape of healthy and tumor tissues: Multispectral 3D microscopy of intact tissues

Ineveld, Ravian Laurens van (Utrecht University, 2022-10-03)

Tissues contain a variety of interconnected cells with different functional states and shapes and this complex organization and tissue architecture is impossible to capture in a single plane. In this thesis, the general ...
Psychosocial challenges of childhood cancer survivorship

Erp, Loes Magdalena Elisabeth van (Utrecht University, 2022-09-15)

Psychosocial challenges of childhood cancer survivorship Childhood cancer survivors (CCS) are a growing population facing unique challenges. This thesis aimed to increase the understanding of psychosocial challenges of ...
A Poorest-First Approach to RSV Vaccine Development

Mazur, Natalie Isabelle (Utrecht University, 2022-09-12)

The principle aim of this thesis was to use a multidisciplinary approach to establish the foundations for an RSV vaccine in lower and lower-middle income countries (LMICs). Four different approaches were used: (1) Global ...
Studies on the treatment of bone metastases

Pielkenrood, Bart Jacob (Utrecht University, 2022-09-28)

Due to earlier detection and improved treatment, cancer patients’ life expectancy has improved. Patients with cancer are living longer, which means they are longer at risk of developing bone metastases. Bone metastases ...
Novel strategies to improve brain development after Encephalopathy of Prematurity: from bench to incubator

Vaes, Josine Elisabeth Gertruda (Utrecht University, 2022-10-17)

Developmental brain injury after extreme preterm birth, also known as ‘Encephalopathy of Prematurity (EoP)’, is commonly encountered in the neonatal intensive care unit and can lead to life-long neurodevelopmental impairments. ...
Individualized cardiovascular disease prevention: Clinical implementation of risk prediction

Hageman, Steven Henricus Johannes (Utrecht University, 2022-10-04)

Cardiovascular diseases are the most common non-communicable diseases globally. In the prevention of cardiovascular events, effective strategies have been developed by reduction of the most important modifiable risk factors, ...
Methods for MRI-guided treatment of painful bone metastases with Focused Ultrasound

Lena, Beatrice (Utrecht University, 2022-09-29)

Bone metastases are among the most common types of metastases and can be very painful. The current standard treatment for painful bone metastases is local external beam radiotherapy (EBRT) combined with opioids, but it is ...
Quantification of Isolated Craniosynostosis: Introducing and Implementing UCSQ as a New Skull Shape Quantification Method

Kronig, Otto Daniël Michaël (Utrecht University, 2022-10-11)

The aim of this thesis was to develop a new, objective and reproducible quantification method for (isolated) craniosynostosis. Additionally, this new method was used for the subgroups, trigonocephaly, scaphocephaly and ...
Clinical Consequences of Quantifying Unilateral Coronal Synostosis

Kronig, Sophia Agatha Johanna (Utrecht University, 2022-10-11)

This thesis focused on the introduction of a novel, objective quantification method for UCS (anterior plagiocephaly) and the volumetric and clinical consequences resulting from this diagnosis. UCS is a challenging simple ...
Towards (semi-)automated surveillance of healthcare-associated infections

Verberk, Janneke Doortje Maria (Utrecht University, 2022-09-29)

Infections that develop within a healthcare institution – simply called healthcare-associated infections – can often be prevented. However, it is important to first find out how and how often these occur. This monitoring ...
Advancements in the multimodal treatment of testicular germ cell tumor

Blok, Joost Marijn (Utrecht University, 2022-09-27)

This thesis concerns testicular germ cell tumor (TGCT). Testicular germ cell tumor is introduced in chapter 1, describing the epidemiology, etiology, diagnosis and disease management. Chapter 2 reviews the literature ...
Maintenance of the virus-specific CD8+ T-cell repertoire: Implications for vaccine strategies

Lanfermeijer, Josien (Utrecht University, 2022-09-15)

T cells play an important role in combatting pathogens. T cells recognize virus-infected cells via their T-cell receptors and are able to clear virus-infected cells from the body. Every T cell has a unique T-cell receptor, ...
Integrating information in stress research

Bonapersona, Valeria (Utrecht University, 2022-08-30)

There are few experiences as engulfing as the subjective experience of stress. It affects multiple biological systems, with temporal and spatial specificity. It depends on genetic predisposition, early- and late- life ...
Trauma Systems: Development Strategies in Emerging Nations

Chowdhury, A H M Sharfuddin Mahmud (Utrecht University, 2022-10-05)

Trauma is the leading cause of death and disability. Numerous studies have shown that trauma systems, which provide an organized approach to acutely injured patients from primary to advanced care, improve outcomes. The aim ...
Coronary artery calcium detection & quantification with current and next-generation CT: It is time for a change

Werf, Niels Roderik van der (Utrecht University, 2022-09-28)

The overall aims of this thesis, entitled ‘Coronary artery calcium detection & quantification with current and next-generation CT’, are to better understand spurious variations in coronary artery calcium (CAC) scoring and ...

Now showing items 20921-20940 of 40729