Rupture of an intracranial aneurysm leads to aneurysmal subarachnoid hemorrhage, a severe type of stroke which is, in part, driven by genetic variation. In the past 10 years, genetic studies of IA have boosted the number ...

Dosing of (chemotherapeutic) agents in pediatric patients with cancer can be challenging. An optimal exposure to chemotherapeutic and anti-emetic agents is needed, either to be effective, and on the other hand, to minimize ...

Although advances have been made toward elucidating the molecular mechanisms of stroke pathology, there are still no clinically effective strategies for poststroke brain repair. A potential therapeutic target, the peri-infarct ...

Pancreatic surgery is complex and remains associated with a high risk of complications. A single complication may provoke a potentially lethal cascade of associated complications. Early recognition and management of ...

Antibiotic resistant bacteria (ARB) and COVID-19 are both important infectious diseases of the 21st century. During my PhD I firstly summarized the available knowledge on ARB transmission pathways, I studied whether ARB ...

Delivering high-quality healthcare requires interprofessional collaboration and shared understanding of patient care goals. However, few health professions education programs are designed with consideration of the interactive ...

Our genomes are 99.5% identical, and yet we are different. Part of this variation can be explained by genetic variation. The genomic locations where a certain nucleotide (a different 'letter' in the DNA sequence) is ...

The overall aim of this thesis was to determine if and how topography of calcium phosphates can be improved for increased efficacy as bone graft materials for maxillofacial and orthopedic surgery. To achieve this objective, ...

Mevalonate Kinase Deficiency (MKD)is a inflammatory disease, characterized by fever and inflammation in different organ systems. The disease is rare with approximately 300 known cases worldwide. This complicates the diagnosis ...

Pediatric oncologic surgery can be improved by bringing novel imaging strategies from the scientific bench to the operation room. This thesis focusses on 3D imaging innovation in surgery for children with neuroblastoma ...