Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease which affects motor neurons, the cells that control movement. Loss of motor neurons leads to muscle paralysis and, therefore, ALS is invariably fatal in 3 ...

While primary colorectal cancer (CRC) can usually be treated well through surgical removal of the affected tissue parts, the threat of this disease lies in the spread to other organs and the formation of secondary lesions, ...

The human intestinal tract is densely colonized by bacteria, fungi, viruses and phages, that together form the gut microbiome. The results presented in this PhD thesis highlight the importance of the gut microbiome as a ...

In this thesis, we focus on using driver and/or passenger mutations detected from WGS to develop machine learning classifiers for cancer diagnostics (Chapter 2 and Chapter 3), as well as to study cancer development (Chapter ...

Hypertension is a major risk factor for the development and progression of cardiovascular disease and the leading risk factor for all-cause mortality worldwide. Although awareness and control of hypertension have improved ...

The resuscitation of severely injured patients is one of the most challenging processes in healthcare. A trauma team must assemble rapidly at unpredictable times and must be prepared for unique and chaotic circumstances ...

Pediatric renal tumors are among the most frequent malignancies in children. The majority of patients is diagnosed with Wilms tumors. While survival rates have reached 90%, patients still suffer from severe long-term side ...

The brain consists of various cell types, including neurons, astrocytes, and microglia. Neurons are important for signal transduction and responsible for the communication within and between brain areas. Astrocytes and ...

In part 1 of this thesis, the accelerated aging process of damaged kidney cells (“cellular senescence) in Chronic Kidney Disease (CKD), and targets for intervention are explored. Senescent kidney cells contribute to renal ...

Epilepsy is characterized by recurrent seizures and affects 50-70 million people worldwide, of which a third do not become seizure free with currently available drugs. Most current drugs are found serendipitously and despite ...