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Optimizing drug delivery in oncology using imaging and therapeutic ultrasound

Maar, Josanne Sophia de (Utrecht University, 2023-01-26)

In the recent years much progress has been made in cancer treatment. Besides the traditional therapies such as chemotherapy, surgery and radiotherapy, targeted therapy and immunotherapy are increasingly being used and have ...
Natural and synthetic lipid nanoparticles for therapeutic RNA delivery

Evers, Martijn Johannes Wilhelmus (Utrecht University, 2023-01-19)

RNA therapeutics can potentially revolutionize the way in which we are able to treat a disease, namely directly at its biological origin. RNA therapeutics can modulate the expression of almost any gene. However, clinical ...
Mechanisms, diagnostics and therapies for thromboinflammation

Clark, Chantal Cheryl (Utrecht University, 2022-01-10)

Thrombosis, the disruption of blood flow in the circulation by a blood clot (thrombus), can cause serious and life-threatening disease and still forms an important healthcare challenge. Thrombosis resulting from cardiovascular ...
Incidence, risk factors and interventions addressing mortality associated with HIV and TB infections among children and adults in Kenya

Onyango, Dickens Otieno (Utrecht University, 2023-01-31)

Tuberculosis (TB) and infection with human immuno-deficiency virus (HIV) are leading infectious causes of morbidity particularly in sub-Saharan Africa, which is disproportionately affected by the two epidemics. Kenya is ...
Doppler ultrasound to improve prediction of adverse perinatal outcomes in low resource settings

Ali, Sam (Utrecht University, 2023-01-12)

Chapter 1 provides the general background for the thesis, providing an overview of the global burden and trends of stillbirths. While most stillbirths result from preventable causes, the possible reasons behind the lack ...
Effective and sustainable patient participation: The patient’s perspective in CF care and CF research

Noordhoek-van der Staaij, Jacqueline Jeannette (Utrecht University, 2023-01-10)

This thesis focuses on how the Dutch CF Foundation defined the patients’ perspective as a starting point for the improvement of quality of care and the making of a patient prioritized research agenda. Quality of care and ...
Food allergy management in daily life: accidental allergic reactions, cofactors and adherence to dietary advice

Versluis, Astrid (Utrecht University, 2023-01-10)

Food allergy is caused by an IgE-mediated immune response to allergenic proteins in a food. It manifests by symptoms of the skin, mucous membranes, gastrointestinal tract, respiratory tract and/or cardiovascular system. ...
Unraveling new therapeutic avenues for breast cancer brain metastasis

Cruz Margarido, Andreia Sofia da (Utrecht University, 2023-01-20)

Significant clinical improvements in diagnostics and therapeutic strategies have increased the survival of patients with breast cancer. The current challenge in the clinic lies in treating patients with metastatic disease, ...
Optimizing perioperative settings after (minimally invasive) esophagectomy: Short-term improvements and long-term outcomes

Fransen, Laura Floor Cornelia (Utrecht University, 2023-01-19)

An esophagectomy – the surgical removal of the esophagus – is a complex procedure, frequently accompanied by complications. To reduce these complications, quick recovery (i.e. ERAS) protocols are being adopted. While oral ...
Structure and hearing preservation in cochlear implant surgery

Jwair, Saad (Utrecht University, 2022-12-22)

Preserving cochlear structures during cochlear implantation is considered one of the most important steps in improving the hearing performance of CI patients. Minimizing trauma to the cochlea, i.e. preserving the residual ...
Hemodynamic changes in acute stroke: Implications for prognosis and treatment

Uniken Venema, Simone Maria (Utrecht University, 2022-12-22)

Herseninfarcten en intracerebrale bloedingen zijn tezamen de één na meest voorkomende oorzaak voor overlijden wereldwijd en de derde meest voorkomende oorzaak van invaliditeit. Er is een gebrek aan effectieve en breed ...
MRI-guided stereotactic radiotherapy for localised prostate cancer

Willigenburg, Thomas (Utrecht University, 2023-01-26)

Although the incidence of prostate cancer is high, improvements in treatments have led to high survival rates in patients with low- and intermediate-risk prostate cancer. Therefore, it is even more important that treatments ...
Geometry, angular momentum and the intrinsic drift of oceanic monopolar vortices

Toorn, Ramses van der (Utrecht University, 1997-10-01)

The intrinsic westward drift of oceanic monopolar vortices is explained in terms of angular momentum dynamics. In turn, the physical origin of this is shown to reside in the broken spherical symmetry of the fluid dynamics ...
Estimands in clinical drug development: from design to regulatory assessment

Mitroiu, Marian (Utrecht University, 2022-12-12)

In this thesis, I investigated the (implicit) use of estimands in the pre-estimand era in clinical trials for regulatory evaluation and approval to understand what estimands may correspond to efficacy investigations and ...
Not All Chromosomes Are Created Equal: Following individual chromosomes in mitosis and beyond

Klaasen, Sjoerd Jurian (Utrecht University, 2023-02-23)

Aneuploidy is a hallmark of cancer and one of the main causes of miscarriages in humans1. Recent technical developments in the field of genomics allows one to count the number of chromosomes in a single cell at high-throughput. ...
Personalizing endocrine therapy for breast cancer using MRI

Ragusi, Massimiliano Achille Adolf-Dino Domenico (Utrecht University, 2022-12-15)

The introduction of adjuvant systemic therapy (AST) has improved patient outcome in breast cancer. However, as the AST indication has shifted towards including more favorable disease profiles, increasingly more patients ...
Optimizing surveillance strategies in gastroenteropancreatic neuroendocrine tumours: Moving towards individualized management

Treijen, Mark Jean Cornel van (Utrecht University, 2022-12-15)

Important challenges in GEP NET management are the wide spectrum in clinical behaviour and heterogeneous course of disease. The aim of this thesis was to optimize and improve current surveillance strategies and promote a ...
Intracranial artery calcifications: Histology, risk factors and clinical relevance

Brouwer, Esther Joanna Maria de (Utrecht University, 2022-12-19)

This dissertation is about the presence and consequences of calcifications in the head. We investigated calcifications in the carotid artery siphon, the basilar artery and calcifications deep in the brain tissue; the basal ...
Remaining challenges for hepatitis C virus elimination in the era of direct-acting antiviral agents

Isfordink, Cas Joos (Utrecht University, 2022-12-15)

Hepatitis C (HCV) is an infectious disease caused by a virus primarily affecting the liver. Approximately 70-80% of HCV-infected individuals develop a chronic HCV infection. If left untreated, progressive liver damage ...
Patient-Tailored Cardiac Resynchronization Therapy: Imaging and Exercise Strategies

Wouters, Philippe Constant (Utrecht University, 2022-11-24)

Better characterisation of the electromechanical substrate (part I) may promote more appropriate patient selection for cardiac resynchronization therapy (CRT) implantation. By developing an and-to-end automated and explainable ...

Now showing items 20841-20860 of 40725