Cognitive deficits frequently occur in brain tumor patients, regardless of tumor type or location, and have a significant impact on their quality of life. To date, unfortunately, the underlying cause of these overarching ...

The complement system is an important part of the human immune system that fights invading pathogens and removes apoptotic host cells, tumor cells and immune complexes. It consists of roughly 30 proteins that circulate in ...

Patients who underwent cancer treatment like surgery or chemotherapy are frequently admitted to the hospital. However, within the hospital sedentary behavior is deeply rooted in the hospital culture. In order te prevent ...

Primary antibody deficiencies (PAD) are a group of disorders characterized by reduced antibody production, leading to a common form of primary immunodeficiency. This group includes specific polysaccharide antibody deficiency, ...

In this thesis, we aim to better understand how the genetic predisposition of ERAPs and MHC-I contributes to autoimmunity. These endoplasmic reticulum aminopeptidases (ERAPs) are involved in trimming peptides before these ...

Although the MR-HIFU treatment of uterine fibroids have been available for over 20 years, still most women worldwide, including the Netherlands, have no access to this noninvasive treatment option. In this thesis some of ...

Following advancements in diagnostic imaging and its widespread use, there has been an increase in the detection of differentiated thyroid cancers (DTC), contributing to the rising incidence of this disease. The increasing ...

Coordination of the electrical signal to induce orchestrated contraction is vital for a proper functioning of the heart. If the signal gets disturbed, the heart becomes vulnerable for the onset of fatal ventricular ...

This thesis discussed ocular surface disease (OSD) in patients with atopic dermatitis (AD) and the effect of dupilumab treatment. The clinical characteristics, risk factors and pathomechanism of OSD were investigated. It ...

Part 1 and Chapter 1 of this dissertation review the available knowledge on intracranial arteriosclerosis. Chapter 1 describes that most studies on the prevalence and risk factors of intracranial arteriosclerosis focus on ...