In recent years, the treatment of acute pancreatitis has significantly improved. However, there is still room for improvement, especially on rarer and less known complications, which is the focus of this dissertation. A ...

Big Data hold great promise for scientific health research and healthcare. Yet data-intensive health research in which various types of data from different sources are collected, (re)used, shared and/or linked on a large ...

The classic structure-function paradigm has long been considered a cornerstone of protein biology, as it posits that the specific functionality of a protein is determined by its unique three-dimensional (3D) structure. ...

Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) are the two most frequently diagnosed developmental conditions. Given their high prevalence, frequent chronic morbidity, and related ...

Cancer is a broad term encompassing various disease. One common characteristic among all types of cancer is the exploitation of physiological processes to their advantage. This exploitation typically involves acquisition ...

The harmonious dance between academia and industry This is an exciting time for RSV research. With the recent approval of the first-ever RSV vaccines and monoclonal antibody (mAb) for all infants, we are on the cusp ...

The aim of this thesis was to study sources of inter-individual variation in brain structure and function in pre-adolescence. This thesis focused on several factors that contribute to this variation, including test-retest ...

Gaining insight into the pathophysiology of rare genetic disorders is of great importance for both diagnosis and treatment. A valuable tool in identifying and characterizing these diseases is untargeted metabolomics, a ...

Over the past decades, cure of children with cancer has become increasingly feasible. However, excess multimorbidity and mortality due to treatment are observed throughout adulthood. Metabolic syndrome (MetS), a risk factor ...

Breast cancer patients and survivors may experience local side effects during and after breast cancer treatment involving breast surgery and adjuvant radiotherapy. The first part of this thesis focuses on the occurrence ...