Protein tyrosine phosphatases (PTPs) have a central role in cell signaling, by dephosphorylating other proteins. PTPs are highly susceptible to oxidation, due to the low pKa of their active sites. Their reactive cysteine ...

Breast cancer is the most common cancer in women and despite advancements in diagnostics and treatment methods that have led to lower mortality rates, it remains one of the leading causes of cancer death among women. In ...

This thesis described the current state of longitudinal data analysis in the pediatric gastrointestinal (GI) surgical literature. Studies on two procedures were performed to gather the best available evidence for minimally ...

Psoriasis is a complex autoimmune disease characterized by dysregulated interactions between keratinocytes and immune cells. Over the past decade, various antimicrobial peptides, chemokines, and cytokines have been discovered ...

Extracellular vesicles (EVs) are small vesicles naturally produced by cells to transfer bioactive content to other cells. This thesis addresses key challenges in translating EV therapeutics in the context of cardiac repair. ...

Bronchiectasis is a heterogenous disease and is diagnosed in patients of all ages, with geographic variability around the globe. The prevalence of bronchiectasis worldwide rose by 40% between 2004 and 2014, and still ...

Traditional biomarkers of breast cancer are dependent on invasive sampling of the areas suspicious of malignancy. In contrast, MRI not only investigates the whole tumor in vivo, but also evaluates the surrounding tissues ...

Every year about 75 children in the Netherlands undergo an allogeneic stem cell transplantation (SCT) as an ultimate treatment for leukemia for instance. Unfortunately, often the complication acute Graft-versus-Host disease ...

In recent years, drug development in oncology switched focus from conventional cytotoxic drugs to targeted therapies. Despite this change in focus, dose selection of anticancer drugs in early drug development is still often ...

Nurses are frequently confronted with situations in which they must deviate from organizational rules and regulations when these rules do not align with their professional standards and beliefs concerning delivering ...