Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • Are CAR-T therapies living up to their hype?: A study using real-world data in two cohorts to determine how well they are actually working in practice compared with bone marrow transplants 
    Schulthess, Duane; Gassull, Daniel; Makady, Amr; Ludlow, Anna; Rothman, Brian; Have, Pieter Ten; Wu, Yiyang; Ekstrom, Leeland; Minnema, Monique; Jagasia, Madan (BMJ Publishing Group, 2021-06)
    With the increasing use of new regulatory tools, like the Food and Drug Administration's breakthrough designation, there are increasing challenges for European health technology assessors (HTAs) to make an accurate assessment ...
  • Enhancer signatures stratify and predict outcomes of non-functional pancreatic neuroendocrine tumors 
    Cejas, Paloma; Drier, Yotam; Dreijerink, Koen M.A.; Brosens, Lodewijk A.A.; Deshpande, Vikram; Epstein, Charles B.; Conemans, Elfi B.; Morsink, Folkert H.M.; Graham, Mindy K.; Valk, Gerlof D.; Vriens, Menno R.; Castillo, Carlos Fernandez del; Ferrone, Cristina R.; Adar, Tomer; Bowden, Michaela; Whitton, Holly J.; Da Silva, Annacarolina; Font-Tello, Alba; Long, Henry W.; Gaskell, Elizabeth; Shoresh, Noam; Heaphy, Christopher M.; Sicinska, Ewa; Kulke, Matthew H.; Chung, Daniel C.; Bernstein, Bradley E.; Shivdasani, Ramesh A. (Nature Research, 2019-08)
    Most pancreatic neuroendocrine tumors (PNETs) do not produce excess hormones and are therefore considered ‘non-functional’1–3. As clinical behaviors vary widely and distant metastases are eventually lethal2,4, biological ...
  • SAFE@HOME – Feasibility study of a telemonitoring platform combining blood pressure and preeclampsia symptoms in pregnancy care 
    van den Heuvel, Josephus F.M.; Kariman, Shariva S.; van Solinge, Wouter W.; Franx, Arie; Lely, A. Titia; Bekker, Mireille N. (Elsevier Ireland Ltd, 2019-09-01)
    Objective: To study the feasibility of a telemonitoring platform for hypertensive disease in pregnancy, consisting of a wireless blood pressure monitor and an app in combination with an integrated preeclampsia symptom ...
  • Content analysis of Advance Directives completed by patients with advanced cancer as part of an Advance Care Planning intervention: insights gained from the ACTION trial 
    Zwakman, Marieke; van Delden, J J M; Jabbarian, L J; Johnsen, A T; Korfage, I J; Preston, N J; Kars, M C; ACTION consortium (Springer-Verlag, 2020-03-01)
    PURPOSE: Writing an Advance Directive (AD) is often seen as a part of Advance Care Planning (ACP). ADs may include specific preferences regarding future care and treatment and information that provides a context for ...
  • Stroke incidence in young adults according to age, subtype, sex, and time trends 
    Ekker, Merel S.; Verhoeven, Jamie I.; Vaartjes, Ilonca; van Nieuwenhuizen, Koen M.; Klijn, Catharina J.M.; de Leeuw, Frank Erik (Lippincott Williams & Wilkins, 2019-05-21)
    OBJECTIVE: To investigate incidence of stroke and its subtypes in young adults, according to sex and age, and to study trends over time. METHODS: We established a nationwide cohort through linkage of national registries ...
  • Equivalency of the diagnostic accuracy of the PHQ-8 and PHQ-9: a systematic review and individual participant data meta-analysis 
    Wu, Yin; Levis, Brooke; Riehm, Kira E; Saadat, Nazanin; Levis, Alexander W; Azar, Marleine; Rice, Danielle B; Boruff, Jill; Cuijpers, Pim; Gilbody, Simon; Ioannidis, John P A; Kloda, Lorie A; McMillan, Dean; Patten, Scott B; Shrier, Ian; Ziegelstein, Roy C; Akena, Dickens H; Arroll, Bruce; Ayalon, Liat; Baradaran, Hamid R; Baron, Murray; Bombardier, Charles H; Butterworth, Peter; Carter, Gregory; Chagas, Marcos H; Chan, Juliana C N; Cholera, Rushina; Conwell, Yeates; de Man-van Ginkel, Janneke M; Fann, Jesse R; Fischer, Felix H; Fung, Daniel; Gelaye, Bizu; Goodyear-Smith, Felicity; Greeno, Catherine G; Hall, Brian J; Harrison, Patricia A; Härter, Martin; Hegerl, Ulrich; Hides, Leanne; Hobfoll, Stevan E; Hudson, Marie; Hyphantis, Thomas; Inagaki, M D; Jetté, Nathalie; Khamseh, Mohammad E; Kiely, Kim M; Kwan, Yunxin; Lamers, Femke; Liu, Shen-Ing; Lotrakul, Manote; Loureiro, Sonia R; Löwe, Bernd; McGuire, Anthony; Mohd-Sidik, Sherina; Munhoz, Tiago N; Muramatsu, Kumiko; Osório, Flávia L; Patel, Vikram; Pence, Brian W; Persoons, Philippe; Picardi, Angelo; Reuter, Katrin; Rooney, Alasdair G; Santos, Iná S; Shaaban, Juwita; Sidebottom, Abbey; Simning, Adam; Stafford, M D; Sung, Sharon; Tan, Pei Lin Lynnette; Turner, Alyna; van Weert, Henk C; White, Jennifer; Whooley, Mary A; Winkley, Kirsty; Yamada, Mitsuhiko; Benedetti, Andrea; Thombs, Brett D (Cambridge University Press, 2020-06)
    BACKGROUND: Item 9 of the Patient Health Questionnaire-9 (PHQ-9) queries about thoughts of death and self-harm, but not suicidality. Although it is sometimes used to assess suicide risk, most positive responses are not ...
  • Cerebral microbleeds are not associated with postoperative delirium and postoperative cognitive dysfunction in older individuals 
    Lachmann, Gunnar; Kant, Ilse; Lammers, Florian; Windmann, Victoria; Spies, Claudia; Speidel, Saya; Borchers, Friedrich; Hadzidiakos, Daniel; Hendrikse, Jeroen; Winterer, Georg; de Bresser, Jeroen; BioCog consortium (Public Library of Science, 2019-06-14)
    BACKGROUND: Cerebral microbleeds (CMB) occur in the context of cerebral small vessel disease. Other brain MRI markers of cerebral small vessel disease are associated with the occurrence of postoperative delirium (POD) and ...
  • Helping Babies Breathe and its effects on intrapartum-related stillbirths and neonatal mortality in low-resource settings: a systematic review 
    Versantvoort, Jorien; Kleinhout, Mirjam; Ockhuysen, HDL; Bloemenkamp, Kitty; de Vries, WB; van den Hoogen, A (BMJ Publishing Group, 2020-02-01)
    Background An important factor in worldwide neonatal mortality is the deficiency in neonatal resuscitation skills among trained professionals. a € Helping Babies Breathe' (HBB) is a simulation-based training course designed ...
  • Correction: MicroRNA regulation of persistent stress-enhanced memory (Molecular Psychiatry, (2020), 25, 5, (965-976), 10.1038/s41380-019-0432-2) 
    Sillivan, Stephanie E; Jamieson, Sarah; de Nijs, Laurence; Jones, Meghan; Snijders, Clara; Klengel, Torsten; Joseph, Nadine F; Krauskopf, Julian; Kleinjans, Jos; Vinkers, Christiaan H; Boks, Marco P M; Geuze, Elbert; Vermetten, Eric; Berretta, Sabina; Ressler, Kerry J; Rutten, Bart P F; Rumbaugh, Gavin; Miller, Courtney A (Springer Nature, 2020-05-01)
    In the original version of this article, the author ‘Christiaan H. Vinkers’ was incorrectly associated with ‘Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands’. ...
  • Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition 
    Christakoudi, Sofia; Kakourou, Artemisia; Markozannes, Georgios; Tzoulaki, Ioanna; Weiderpass, Elisabete; Brennan, Paul; Gunter, Marc; Dahm, Christina C; Overvad, Kim; Olsen, Anja; Tjønneland, Anne; Boutron-Ruault, Marie-Christine; Madika, Anne-Laure; Severi, Gianluca; Katzke, Verena; Kühn, Tilman; Bergmann, Manuela M; Boeing, Heiner; Karakatsani, Anna; Martimianaki, Georgia; Thriskos, Paschalis; Masala, Giovanna; Sieri, Sabina; Panico, Salvatore; Tumino, Rosario; Ricceri, Fulvio; Agudo, Antonio; Redondo-Sánchez, Daniel; Colorado-Yohar, Sandra M; Mokoroa, Olatz; Melander, Olle; Stocks, Tanja; Häggström, Christel; Harlid, Sophia; Bueno-de-Mesquita, Bas; van Gils, Carla H; Vermeulen, Roel C H; Khaw, Kay-Tee; Wareham, Nicholas J; Tong, Tammy Y N; Freisling, Heinz; Johansson, Mattias; Lennon, Hannah; Aune, Dagfinn; Riboli, Elio; Trichopoulos, Dimitrios; Trichopoulou, Antonia; Tsilidis, Konstantinos K (John Wiley & Sons Inc., 2020-05-15)
    Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident ...
  • Optimisation of telephone triage of callers with symptoms suggestive of acute cardiovascular disease in out-of-hours primary care: observational design of the Safety First study 
    Erkelens, Daphne Ca; Wouters, Loes Tcm; Utrecht, University; Damoiseaux, Roger Amj; De Groot, Esther; Hoes, Arno W; Rutten, Frans H (BMJ Publishing Group, 2019-07-01)
    INTRODUCTION: In the Netherlands, the 'Netherlands Triage Standard' (NTS) is frequently used as digital decision support system for telephone triage at out-of-hours services in primary care (OHS-PC). The aim of the NTS is ...
  • The mixed model for the analysis of a repeated-measurement multivariate count data 
    Martin, Ivonne; Uh, Hae-Won; Supali, Taniawati; Mitreva, Makedonka; Houwing-Duistermaat, Jeanine J. (John Wiley & Sons Inc., 2019-05-30)
    Clustered overdispersed multivariate count data are challenging to model due to the presence of correlation within and between samples. Typically, the first source of correlation needs to be addressed but its quantification ...
  • Effects of body mass on microstructural features of the osteochondral unit: A comparative analysis of 37 mammalian species 
    Mancini, I A D; Rieppo, L; Pouran, B; Afara, I O; Braganca, F M Serra; van Rijen, M H P; Kik, M; Weinans, H; Toyras, J; van Weeren, P R; Malda, J (Elsevier, 2019-10)
    Since Galileo's days the effect of size on the anatomical characteristics of the structural elements of the body has been a subject of interest. However, the effects of scaling at tissue level have received little interest ...
  • White matter microstructure and network-connectivity in emerging adults with subclinical psychotic experiences 
    Michielse, Stijn; Lange, Iris; Bakker, Jindra; Goossens, Liesbet; Verhagen, Simone; Wichers, Marieke; Lieverse, Ritsaert; Schruers, Koen; van Amelsvoort, Therese; van Os, Jim; Marcelis, Machteld (Springer New York, 2020-10-01)
    Group comparisons of individuals with psychotic disorder and controls have shown alterations in white matter microstructure. Whether white matter microstructure and network connectivity is altered in adolescents with ...
  • The Relationship Between Polygenic Risk Scores and Cognition in Schizophrenia 
    Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER) (Oxford University Press, 2020-03)
    Background: Cognitive impairment is a clinically important feature of schizophrenia. Polygenic risk score (PRS) methods have demonstrated genetic overlap between schizophrenia, bipolar disorder (BD), major depressive ...
  • The Translational Landscape of the Human Heart 
    van Heesch, Sebastiaan; Witte, Franziska; Schneider-Lunitz, Valentin; Schulz, Jana F; Adami, Eleonora; Faber, Allison B; Kirchner, Marieluise; Maatz, Henrike; Blachut, Susanne; Sandmann, Clara-Louisa; Kanda, Masatoshi; Worth, Catherine L; Schafer, Sebastian; Calviello, Lorenzo; Merriott, Rhys; Patone, Giannino; Hummel, Oliver; Wyler, Emanuel; Obermayer, Benedikt; Mücke, Michael B; Lindberg, Eric L; Trnka, Franziska; Memczak, Sebastian; Schilling, Marcel; Felkin, Leanne E; Barton, Paul J R; Quaife, Nicholas M; Vanezis, Konstantinos; Diecke, Sebastian; Mukai, Masaya; Mah, Nancy; Oh, Su-Jun; Kurtz, Andreas; Schramm, Christoph; Schwinge, Dorothee; Sebode, Marcial; Harakalova, Magdalena; Asselbergs, Folkert W; Vink, Aryan; de Weger, Roel A; Viswanathan, Sivakumar; Widjaja, Anissa A; Gärtner-Rommel, Anna; Milting, Hendrik; Dos Remedios, Cris; Knosalla, Christoph; Mertins, Philipp; Landthaler, Markus; Vingron, Martin; Linke, Wolfgang A; Seidman, Jonathan G; Seidman, Christine E; Rajewsky, Nikolaus; Ohler, Uwe; Cook, Stuart A; Hubner, Norbert (Elsevier, 2019-06-27)
    Gene expression in human tissue has primarily been studied on the transcriptional level, largely neglecting translational regulation. Here, we analyze the translatomes of 80 human hearts to identify new translation events ...
  • Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration 
    Małecki, Jędrzej; Willemen, Hanneke L D M; Pinto, Rita; Ho, Angela Y Y; Moen, Anders; Eijkelkamp, Niels; Falnes, Pål Ø (American Society for Biochemistry and Molecular Biology Inc., 2019-08-02)
    Lysine methylation is a common post-translational modification of nuclear and cytoplasmic proteins, but is also present in mitochondria. The human protein denoted "family with sequence similarity 173 member B" (FAM173B) ...
  • MicroRNA regulation of persistent stress-enhanced memory 
    Sillivan, Stephanie E; Jamieson, Sarah; de Nijs, Laurence; Jones, Meghan; Snijders, Clara; Klengel, Torsten; Joseph, Nadine F; Krauskopf, Julian; Kleinjans, Jos; Vinkers, Christiaan H; Boks, Marco P M; Geuze, Elbert; Vermetten, Eric; Berretta, Sabina; Ressler, Kerry J; Rutten, Bart P F; Rumbaugh, Gavin; Miller, Courtney A (Springer Nature, 2020-05-01)
    Disruption of persistent, stress-associated memories is relevant for treating posttraumatic stress disorder (PTSD) and related syndromes, which develop in a subset of individuals following a traumatic event. We previously ...
  • Antenatal staging of congenital lower urinary tract obstruction 
    Fontanella, F; van Scheltema, P N Adama; Duin, L; Cohen-Overbeek, T E; Pajkrt, E; Bekker, M N; Willekes, C; Oepkes, D; Bilardo, C M (John Wiley & Sons Inc., 2019-04-01)
    Objective: To propose a staging system for congenital lower urinary tract obstruction (LUTO) capable of predicting the severity of the condition and its prognosis. Methods: This was a national retrospective study carried ...
  • Fetal megacystis: a lot more than LUTO 
    Fontanella, F; Maggio, L; Verheij, J B G M; Duin, L K; Adama Van Scheltema, P N; Cohen-Overbeek, T E; Pajkrt, E; Bekker, M; Willekes, C; Bax, C J; Gracchi, V; Oepkes, D; Bilardo, C M (John Wiley & Sons Inc., 2019-06-01)
    Objective: Fetal megacystis presents a challenge in terms of counseling and management because of its varied etiology and evolution. The aim of this study was to present a comprehensive overview of the underlying etiologies ...