Recently added

DSpace/Manakin Repository

UMC Repository: Recent submissions

  • Organization framework and preliminary findings from the Athens First-Episode Psychosis Research Study 
    Xenaki, Lida-Alkisti; Kollias, Costas T; Stefanatou, Pentagiotissa; Ralli, Irene; Soldatos, Rigas-Filippos; Dimitrakopoulos, Stefanos; Hatzimanolis, Alex; Triantafyllou, Theoni-Fani; Kosteletos, Ioannis; Vlachos, Ilias I; Selakovic, Mirjana; Foteli, Stefania; Mantonakis, Leonidas; Ermiliou, Vassiliki; Voulgaraki, Marina; Psarra, Evagelia; Gülöksüz, Sinan; van Os, Jim; Stefanis, Nikos C (Wiley-Blackwell, 2020-06)
    Aims: Athens First-Episode Psychosis (FEP) Research study, aims to explore the potential associations between multiple genetic, environmental and neurometabolic risk factors of psychotic disorders, through the clinical ...
  • Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study 
    van Os, Jim; Pries, Lotta-Katrin; Delespaul, Philippe; Kenis, Gunter; Luykx, Jurjen J; Lin, Bochao D; Richards, Alexander L; Akdede, Berna; Binbay, Tolga; Altınyazar, Vesile; Yalınçetin, Berna; Gümüş-Akay, Güvem; Cihan, Burçin; Soygür, Haldun; Ulaş, Halis; Cankurtaran, Eylem Şahin; Kaymak, Semra Ulusoy; Mihaljevic, Marina M; Petrovic, Sanja Andric; Mirjanic, Tijana; Bernardo, Miguel; Cabrera, Bibiana; Bobes, Julio; Saiz, Pilar A; García-Portilla, María Paz; Sanjuan, Julio; Aguilar, Eduardo J; Santos, José Luis; Jiménez-López, Estela; Arrojo, Manuel; Carracedo, Angel; López, Gonzalo; González-Peñas, Javier; Parellada, Mara; Maric, Nadja P; Atbaşoğlu, Cem; Ucok, Alp; Alptekin, Köksal; Saka, Meram Can; Arango, Celso; O'Donovan, Michael; Rutten, Bart P F; Guloksuz, Sinan; Genetic Risk and Outcome Investigators (GROUP) (Cambridge University Press, 2020-08)
    BACKGROUND: First-degree relatives of patients with psychotic disorder have higher levels of polygenic risk (PRS) for schizophrenia and higher levels of intermediate phenotypes. METHODS: We conducted, using two different ...
  • Determinants of unbearable suffering in hospice patients who died due to Euthanasia: A retrospective cohort study 
    Bos, Dieuwke C.; de Graaf, Everlien; de Graeff, Alexander; Teunissen, Saskia C.C.M. (Taylor and Francis Ltd., 2021-07-03)
    In this retrospective study, determinants of unbearable suffering in hospice patients who died due to euthanasia were analyzed. The four dimensions of suffering (physical, psychological, social, and existential) were used ...
  • Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing 
    Rudnik-Jansen, Imke; Tellegen, Anna R; Pouran, Behdad; Schrijver, Karin; Meij, Björn P; Emans, Pieter J; de Gendt, Erin; Thomas, Rachel E; Kik, Marja J L; de Visser, Huub M; Weinans, Harrie; Egas, Annelies; van Maarseveen, Erik; Woike, Nina; Mihov, George; Thies, Jens; Tryfonidou, Marianna A; Creemers, Laura B (John Wiley & Sons Inc., 2019-10)
    Background and Purpose: Corticosteroids are intra-articularly injected to relieve pain in joints with osteoarthritis (OA) or acute tissue damage such as ligament or tendon tears, despite its unverified contraindication in ...
  • Motor function impairment is an early sign of CLN3 disease 
    Kuper, Willemijn F.E.; Van Alfen, Claudia; Van Eck, Linda; Huijgen, Barbara C.H.; Nieuwenhuis, Edward E.S.; Van Brussel, Marco; Van Hasselt, Peter M. (Lippincott Williams & Wilkins, 2019-07-16)
    ObjectiveTo delineate timing of motor decline in CLN3 disease.MethodsMotor function, assessed by the 6-Minute Walk Test (6MWT), was evaluated repeatedly in 15 patients with CLN3 disease, resulting in 65 test results and ...
  • Measures used to assess impact of providing care among informal caregivers of persons with stroke, spinal cord injury, or amputation: a systematic review 
    Scholten, Eline W M; Hillebregt, Chantal F; Ketelaar, Marjolijn; Visser-Meily, Johanna M A; Post, Marcel W M (Informa Healthcare, 2021-03-12)
    Purpose: (1) To identify measures used to evaluate the impact of caregiving among caregivers of persons with stroke, spinal cord injury, and amputation; and (2) to systematically evaluate their clinimetric properties ...
  • Vitamin D concentration and psychotic disorder: Associations with disease status, clinical variables and urbanicity 
    for G.R.O.U.P. (Cambridge University Press, 2020-07-01)
    Background The association between schizophrenia and decreased vitamin D levels is well documented. Low maternal and postnatal vitamin D levels suggest a possible etiological mechanism. Alternatively, vitamin D deficiency ...
  • Neural responses during extinction learning predict exposure therapy outcome in phobia: results from a randomized-controlled trial 
    Lange, Iris; Goossens, Liesbet; Michielse, Stijn; Bakker, Jindra; Vervliet, Bram; Marcelis, Machteld; Wichers, Marieke; van Os, Jim; van Amelsvoort, Therese; Schruers, Koen (Springer Nature, 2020-02-01)
    Extinction learning is assumed to represent a core mechanism underlying exposure therapy. Empirical evaluations of this assumption, however, are largely lacking. The current study investigated whether neural activations ...
  • Premorbid Adjustment and IQ in Patients With First-Episode Psychosis: A Multisite Case-Control Study of Their Relationship With Cannabis Use 
    WP2 EU-GEI GROUP (Oxford University Press, 2020-05)
    Psychotic patients with a lifetime history of cannabis use generally show better cognitive functioning than other psychotic patients. Some authors suggest that cannabis-using patients may have been less cognitively impaired ...
  • Brain Activity and Cerebral Oxygenation After Perinatal Arterial Ischemic Stroke Are Associated With Neurodevelopment 
    Wagenaar, Nienke; van den Berk, Daphne J. M.; Lemmers, Petra M. A.; van der Aa, Niek E.; Dudink, Jeroen; van Bel, Frank; Groenendaal, Floris; de Vries, Linda S.; Benders, Manon J. N. L.; Alderliesten, Thomas (Lippincott Williams & Wilkins, 2019-10-01)
    Background and Purpose—In infants with perinatal arterial ischemic stroke (PAIS), early prognosis of neurodevelopmental outcome is important to adequately inform parents and caretakers. Early continuous neuromonitoring ...
  • Zirconium-89-labelled rituximab PET-CT in orbital inflammatory disease 
    Laban, Kamil G.; Kalmann, Rachel; Leguit, Roos J.; de Keizer, Bart (Springer Berlin, 2019-07-30)
    BACKGROUND: Orbital inflammatory diseases are a heterogenic group of conditions that often entail a difficult diagnostic process and many patients are treatment resistant. Inflammatory diseases can be visualized by ...
  • The association between schizophrenia and the immune system: Review of the evidence from unbiased ‘omic-studies’ 
    van Mierlo, Hans C.; Schot, Aron; Boks, Marco P.M.; de Witte, Lot D. (Elsevier, 2020-03)
    A role for immune processes in the pathogenesis of schizophrenia has been suggested by genetic and epidemiological studies, as well as cross-sectional studies on blood and brain samples. However, results are heterogeneous, ...
  • Predictors for losing reduction after reposition in conservatively treated both-bone forearm fractures in 38 children 
    Ploegmakers, Joris J.W.; Groen, Wilhelmina M.G.A.C.; Haverlag, Robert; Bulstra, Sjoerd K. (Elsevier, 2020-02-27)
    Backgrounds: Alignment loss after reduction and cast immobilisation of angulated and/or complete displaced forearm fractures is challenging. Many authors have tried to describe risk factors and create indices (initial ...
  • Two-year persistence with teriparatide improved significantly after introduction of an educational and motivational support program 
    van Maren, M A; Wyers, C E; Driessen, J H M; Visser, J V; de Vries, F; van de Wijdeven, K; Gevers, S; Lems, W F; Emmelot-Vonk, M H; van den Bergh, J P W (Springer Science and Business Media Deutschland GmbH, 2019-09)
    Summary: This study evaluated the 2-year persistence with teriparatide in the Netherlands. Analyses showed that the risk of non-persistence was 28% lower in patients who were followed according to an additional educational ...
  • Coronary artery calcification in middle-aged women with premature ovarian insufficiency 
    Gunning, Marlise N.; Meun, Cindy; van Rijn, Bas B.; Maas, Angela H.E.M.; Benschop, Laura; Franx, Arie; Boersma, Eric; Budde, Ricardo P.J.; Appelman, Yolande; Lambalk, Cornelis B.; Eijkemans, Rene; Velthuis, Birgitta K.; Laven, Joop S.E.; Fauser, Bart C.J.M.; Baart, Sara; Brouwers, Laura; Cannegieter, Suzanne; Dam, Veerle; Daan, Nadine; Eijkemans, Rene; Ferrari, Michel; de Groot, Christianne; Hoek, Annemieke; Koffijberg, Erik; Koster, Wendy; Kruit, Mark; Lagerweij, Giske; Lambalk, Nils; Linstra, Katie; van der Lugt, Aad; van den Brink, Antoinette Maassen; Middeldorp, Saskia; Moons, Karel; van Lennep, Jeanine Roeters; Roos-Hesselink, Jolien; Scheres, Luuk; van der Schouw, Yvonne; Steegers, Eric; Steegers, Regine; Terwindt, Gisela; Wermer, Marieke; Zick, Bart; Zoet, Gerbrand; On behalf of the CREW-consortium (Wiley-Blackwell, 2019-08-01)
    Objective: Women with premature ovarian insufficiency (POI) enter menopause before age 40. Early menopause was associated with increased risk for coronary artery disease (CAD), death from cardiovascular disease and all-cause ...
  • Glioma EVs Contribute to Immune Privilege in the Brain 
    Abels, Erik R.; Broekman, Marike L.D.; Breakefield, Xandra O.; Maas, Sybren L.N. (Cell Press, 2019-07-01)
    Glioblastoma cells release extracellular vesicles (EVs), sometimes referred to as microvesicles and exosomes, to transfer immune modulating molecules to immune cells, resulting in an immune privileged microenvironment. ...
  • Enterococcus faecium TIR-Domain Genes Are Part of a Gene Cluster Which Promotes Bacterial Survival in Blood 
    Wagner, Theresa M.; Janice, Jessin; Paganelli, Fernanda L.; Willems, Rob J.; Askarian, Fatemeh; Pedersen, Torunn; Top, Janetta; De Haas, Carla; Van Strijp, Jos A.; Johannessen, Mona; Hegstad, Kristin (Elsevier, 2018-01-01)
    Enterococcus faecium has undergone a transition to a multidrug-resistant nosocomial pathogen. The population structure of E. faecium is characterized by a sharp distinction of clades, where the hospital-adapted lineage is ...
  • Phylogenomics of Enterococcus faecalis from wild birds: new insights into host-associated differences in core and accessory genomes of the species 
    León-Sampedro, Ricardo; del Campo, Rosa; Rodriguez-Baños, Mercedes; Lanza, Val F.; Pozuelo, María José; Francés-Cuesta, Carlos; Tedim, Ana P.; Freitas, Ana R.; Novais, Carla; Peixe, Luísa; Willems, Rob J.L.; Corander, Jukka; González Candelas, Fernando; Baquero, Fernando; Coque, Teresa M. (Wiley-Blackwell, 2019-08)
    Wild birds have been suggested to be reservoirs of antimicrobial resistant and/or pathogenic Enterococcus faecalis (Efs) strains, but the scarcity of studies and available sequences limit our understanding of the population ...
  • Fully automated QRS area measurement for predicting response to cardiac resynchronization therapy 
    Plesinger, Filip; van Stipdonk, Antonius M W; Smisek, Radovan; Halamek, Josef; Jurak, Pavel; Maass, Alexander H; Meine, Mathias; Vernooy, Kevin; Prinzen, Frits W (Churchill Livingstone, 2020-11-01)
    BACKGROUND: Cardiac resynchronization therapy (CRT) is an established treatment in patients with heart failure and conduction abnormalities. However, a significant number of patients do not respond to CRT. Currently employed ...
  • Significant inter- and intra-laboratory variation in grading of invasive breast cancer: A nationwide study of 33,043 patients in the Netherlands 
    van Dooijeweert, Carmen; van Diest, Paul J; Willems, Stefan M; Kuijpers, Chantal C H J; van der Wall, Elsken; Overbeek, Lucy I H; Deckers, Ivette A G (John Wiley & Sons Inc., 2020-02-01)
    Accurate, consistent and reproducible grading by pathologists is of key-importance for identification of individual patients with invasive breast cancer (IBC) that will or will not benefit from adjuvant systemic treatment. ...