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Now showing items 19881-19900 of 40729

Comparison of multi-delay FAIR and pCASL labeling approaches for renal perfusion quantification at 3T MRI

Harteveld, Anita A; de Boer, Anneloes; Franklin, Suzanne Lisa; Leiner, Tim; van Stralen, Marijn; Bos, Clemens (Springer-Verlag, 2020-02)

OBJECTIVE: To compare the most commonly used labeling approaches, flow-sensitive alternating inversion recovery (FAIR) and pseudocontinuous arterial spin labeling (pCASL), for renal perfusion measurement using arterial ...
Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons

Döhner, Katinka; Ramos-Nascimento, Ana; Bialy, Dagmara; Anderson, Fenja; Hickford-Martinez, Ana; Rother, Franziska; Koithan, Thalea; Rudolph, Kathrin; Buch, Anna; Prank, Ute; Binz, Anne; Hügel, Stefanie; Lebbink, Robert Jan; Hoeben, Rob C; Hartmann, Enno; Bader, Michael; Bauerfeind, Rudolf; Sodeik, Beate (Public Library of Science, 2018-01)

Herpesviruses are large DNA viruses which depend on many nuclear functions, and therefore on host transport factors to ensure specific nuclear import of viral and host components. While some import cargoes bind directly ...
Attenuation of cGAS-STING signaling is mediated by a p62/SQSTM1-dependent autophagy pathway activated by TBK1

Prabakaran, Thaneas; Bodda, Chiranjeevi; Krapp, Christian; Zhang, Bao-Cun; Christensen, Maria H; Sun, Chenglong; Reinert, Line; Cai, Yujia; Jensen, Søren B; Skouboe, Morten K; Nyengaard, Jens R; Thompson, Craig B; Lebbink, Robert Jan; Sen, Ganes C; van Loo, Geert; Nielsen, Rikke; Komatsu, Masaaki; Nejsum, Lene N; Jakobsen, Martin R; Gyrd-Hansen, Mads; Paludan, Søren R (Springer Science and Business Media Deutschland GmbH, 2018-04-13)

Negative regulation of immune pathways is essential to achieve resolution of immune responses and to avoid excess inflammation. DNA stimulates type I IFN expression through the DNA sensor cGAS, the second messenger cGAMP, ...
Comment on "Type I CD20 Antibodies Recruit the B Cell Receptor for Complement-Dependent Lysis of Malignant B Cells"

Evers, Mitchell; Kruse, Elizabeth; Hamdan, Firas; Lebbink, Robert-Jan; Leusen, Jeanette H W (American Association of Immunologists, 2018-04-15)
RNA accessibility impacts potency of Tough Decoy microRNA inhibitors

Hooykaas, Marjolein J G; Soppe, Jasper A; De Buhr, Hendrik M; Kruse, Elisabeth; Wiertz, Emmanuel J H J; Lebbink, Robert J (Landes Bioscience, 2018-11-02)

MicroRNAs (miRNAs) are small RNA molecules that post-transcriptionally regulate gene expression through silencing of complementary target mRNAs. miRNAs are involved in many biological processes, including cell proliferation, ...
Advanced single voxel 1H magnetic resonance spectroscopy techniques in humans: Experts' consensus recommendations

The Experts' Working Group on Advanced Single Voxel H MRS (John Wiley & Sons Inc., 2020-01-10)

Conventional proton MRS has been successfully utilized to noninvasively assess tissue biochemistry in conditions that result in large changes in metabolite levels. For more challenging applications, namely, in conditions ...
Pure Fruit Juice and Fruit Consumption Are Not Associated with Incidence of Type 2 Diabetes after Adjustment for Overall Dietary Quality in the European Prospective Investigation into Cancer and Nutrition-Netherlands (EPIC-NL) Study

Scheffers, Floor R; Wijga, Alet H; Verschuren, W M Monique; van der Schouw, Yvonne T; Sluijs, Ivonne; Smit, Henriëtte A; Boer, Jolanda M A (Elsevier, 2020-06-01)

Dietary guidelines on pure fruit juice consumption vary from country to country regarding the inclusion of pure fruit juice in the recommendations as an acceptable alternative for fruit. Current epidemiological evidence ...
Inherently decoupled H-1 antennas and P-31 loops for metabolic imaging of liver metastasis at 7 T

Rivera, Debra; Kalleveen, Irene; de Castro, Catalina Arteaga; van Laarhoven, Hanneke; Klomp, Dennis; van der Kemp, Wybe; Stoker, Jaap; Nederveen, Aart (John Wiley & Sons Inc., 2020-04-01)

High field 31P spectroscopy has thus far been limited to diffuse liver disease. Unlike lower field-strength scanners, there is no body coil in the bore of the 7 T and despite inadequate penetration depth (<10 cm), surface ...
Feasibility of imaging 90Y microspheres at diagnostic activity levels for hepatic radioembolization treatment planning

Kunnen, Britt; Dietze, Martijn M A; Braat, Arthur J A T; Lam, Marnix G E H; Viergever, Max A; de Jong, Hugo W A M (John Wiley & Sons Inc., 2020-03-01)

PURPOSE: Prior to 90 Y hepatic radioembolization, a dosage of 99m Tc-macroaggregated albumin ( 99m Tc-MAA) is administered to simulate the distribution of the 90 Y-loaded microspheres. This pretreatment procedure enables ...
A single nucleotide C3 polymorphism associates with clinical outcome after lung transplantation

Kardol-Hoefnagel, Tineke; Budding, Kevin; van de Graaf, Eduard A.; Setten, Jessica van; van Rossum, Oliver A.; Oudijk, Erik Jan D.; Otten, Henderikus G. (Frontiers Media S. A., 2019-09-01)

Background: Development of chronic rejection is still a severe problem and causes high mortality rates after lung transplantation (LTx). Complement activation is important in the development of acute rejection (AR) and ...
De novo and inherited variants in ZNF292 underlie a neurodevelopmental disorder with features of autism spectrum disorder

Undiagnosed Diseases Network, (Lippincott Williams & Wilkins, 2020-03-01)

PURPOSE: Intellectual disability (ID) and autism spectrum disorder (ASD) are genetically heterogeneous neurodevelopmental disorders. We sought to delineate the clinical, molecular, and neuroimaging spectrum of a novel ...
Fostering patient-centredness by following patients outside the clinical setting: an interview study

Grau Canét-Wittkampf, Christel; Eijkelboom, Charlotte; Mol, Saskia; Utrecht, University; Hendriks, Iris; de Groot, Esther (BioMed Central, 2020-01-15)

BACKGROUND: Patient-centredness is considered a core competency for health professionals. To support faculty in designing courses focused on patient-centredness, an understanding of how educational interventions lead to ...
T-Cell Compartmentalization and Functional Adaptation in Autoimmune Inflammation: Lessons From Pediatric Rheumatic Diseases.

Mijnheer, Gerdien; van Wijk, Femke (Frontiers Media S. A., 2019-05)

Chronic inflammatory diseases are characterized by a disturbed immune balance leading to recurring episodes of inflammation in specific target tissues, such as the joints in juvenile idiopathic arthritis. The tissue becomes ...
Using Machine Learning and Structural Neuroimaging to Detect First Episode Psychosis: Reconsidering the Evidence

Vieira, Sandra; Gong, Qi Yong; Pinaya, Walter H.L.; Scarpazza, Cristina; Tognin, Stefania; Crespo-Facorro, Benedicto; Tordesillas-Gutierrez, Diana; Ortiz-García, Victor; Setien-Suero, Esther; Scheepers, Floortje E.; Van Haren, Neeltje E.M.; Marques, Tiago R.; Murray, Robin M.; David, Anthony; Dazzan, Paola; McGuire, Philip; Mechelli, Andrea (Oxford University Press, 2020-01-04)

Despite the high level of interest in the use of machine learning (ML) and neuroimaging to detect psychosis at the individual level, the reliability of the findings is unclear due to potential methodological issues that ...
Trends in pediatric epilepsy surgery in Europe between 2008 and 2015: Country-, center-, and age-specific variation

European Survey Group (Wiley-Blackwell, 2020-02)

OBJECTIVE: To profile European trends in pediatric epilepsy surgery (<16 years of age) between 2008 and 2015. METHODS: We collected information on volumes and types of surgery, pathology, and seizure outcome from 20 ...
Influence of epilepsy surgery on developmental outcomes in children

Braun, Kees P.J. (W.B. Saunders Ltd, 2020-01-01)

Epilepsy surgery is the most effective treatment option for children with refractory focal lesional epilepsy, with seizure-freedom rates exceeding 70% two years after surgery. Although numbers of procedures in children are ...
Using three-dimensional ultrasound in predicting complex gastroschisis: A longitudinal, prospective, multicenter cohort study

Hijkoop, Annelieke; Lap, Chiara C.M.M.; Aliasi, Moska; Mulder, Eduard J.H.; Kramer, William L.M.; Brouwers, Hens A.A.; van Baren, Robertine; Pajkrt, Eva; van Kaam, Anton H.; Bilardo, Caterina M.; Pistorius, Lourens R.; Visser, Gerard H.A.; Wijnen, René M.H.; Tibboel, Dick; Manten, Gwendolyn T.R.; Cohen-Overbeek, Titia E. (John Wiley & Sons Inc., 2019-12)

OBJECTIVE: To determine whether complex gastroschisis (ie, intestinal atresia, perforation, necrosis, or volvulus) can prenatally be distinguished from simple gastroschisis by fetal stomach volume and stomach-bladder ...
4C-seq from beginning to end: A detailed protocol for sample preparation and data analysis

Krijger, Peter H L; Geeven, Geert; Bianchi, Valerio; Hilvering, Catharina R E; de Laat, Wouter (Academic Press Inc., 2020-01-01)

Chromosome conformation capture (3C) methods measure DNA contact frequencies based on nuclear proximity ligation, to uncover in vivo genomic folding patterns. 4C-seq is a derivative 3C method, designed to search the genome ...
Differential insular cortex subregional vulnerability to alpha-synuclein pathology in Parkinson's disease and dementia with Lewy bodies

Fathy, Y. Y.; Jonker, A. J.; Oudejans, E.; de Jong, F. J.J.; van Dam, A. M.W.; Rozemuller, A. J.M.; van de Berg, W. D.J. (Wiley-Blackwell, 2019-04-01)

Aim: The insular cortex consists of a heterogenous cytoarchitecture and diverse connections and is thought to integrate autonomic, cognitive, emotional and interoceptive functions to guide behaviour. In Parkinson's disease ...
Quantitative Third Harmonic Generation Microscopy for Assessment of Glioma in Human Brain Tissue

Zhang, Zhiqing; de Munck, Jan C.; Verburg, Niels; Rozemuller, Annemieke J.; Vreuls, Willem; Cakmak, Pinar; van Huizen, Laura M.G.; Idema, Sander; Aronica, Eleonora; de Witt Hamer, Philip C.; Wesseling, Pieter; Groot, Marie Louise (Wiley-VCH Verlag, 2019-06-05)

Distinguishing tumors from normal brain cells is important but challenging in glioma surgery due to the lack of clear interfaces between the two. The ability of label-free third harmonic generation (THG) microscopy in ...

Now showing items 19881-19900 of 40729