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Now showing items 19861-19880 of 40729

Subtype switching in breast cancer brain metastases: a multicenter analysis

Hulsbergen, Alexander F C; Claes, An; Kavouridis, Vasileios K; Ansaripour, Ali; Nogarede, Claudine; Hughes, Melissa E; Smith, Timothy R; Brastianos, Priscilla K; Verhoeff, Joost J C; Lin, Nancy U; Broekman, Marike L D (Oxford University Press, 2020-08-01)

BACKGROUND: Breast cancer (BC) brain metastases (BM) can have discordant hormonal or human epidermal growth factor receptor 2 (HER2) expression compared with corresponding primary tumors. This study aimed to describe ...
Gram-negative Late-onset Sepsis in Extremely Low Birth Weight Infants Is Emerging in The Netherlands Despite Quality Improvement Programs and Antibiotic Stewardship!: Late-onset sepsis in extremely low birth weight infants

Ran, Nicolien; van den Hoogen, A; Hemels, Marieke A C (Lippincott Williams & Wilkins, 2019-09-01)

BACKGROUND: Late-onset sepsis (LOS) is still an important cause of morbidity and mortality in premature infants. Indwelling devices and lower birth weight (BW) are the most important risk factors. Quality improvement ...
Expressive deficits and amotivation as mediators of the associations between cognitive problems and functional outcomes: Results from two independent cohorts

PROGR-S investigators; GROUP Investigators (Elsevier, 2020-04)

Many individuals with severe mental disorders have difficulties in vocational and social functioning, which are regarded the most important outcomes, together with clinical symptoms. To understand the underlying mechanisms, ...
Atypical chromosome 22q11.2 deletions are complex rearrangements and have different mechanistic origins

International 22q11.2 Brain, Behavior Consortium (Oxford University Press, 2019-11-15)

The majority (99%) of individuals with 22q11.2 deletion syndrome (22q11.2DS) have a deletion that is caused by non-allelic homologous recombination between two of four low copy repeat clusters on chromosome 22q11.2 (LCR22s). ...
Long-term follow-up after successful Essure sterilization: evaluation of patient satisfaction, symptoms, and the influence of negative publicity

Vleugels, Michel P H; Veersema, Sebastiaan; Braat, Didi D M; Nieboer, Theodoor E (Elsevier, 2019-12-01)

OBJECTIVE: To evaluate long-term patient satisfaction and symptoms after successful Essure sterilization and the influence of negative publicity on patients' opinion. DESIGN: Survey study. SETTING: Two nonacademic hospitals. ...
Symptomatic Bilateral Granulomas after Essure Sterilization

Hoogendam, Jacob P; Vreuls, Celien P H; Veersema, Sebastiaan (Elsevier, 2020-09)
Doppler gradients, valve area and ventricular function in pregnant women with aortic or pulmonary valve disease: Left versus right

Siegmund, Anne S.; Pieper, Petronella G.; Mulder, Barbara J.M.; Sieswerda, Gertjan Tj; van Dijk, Arie P.J.; Roos-Hesselink, Jolien W.; Jongbloed, Monique R.M.; Konings, Thelma C.; Bouma, Berto J.; Groen, Henk; Sollie-Szarynska, Krystyna M.; Kampman, Marlies A.M.; Bilardo, Caterina M.; van Veldhuisen, Dirk J.; Aalberts, Jan J.J. (Elsevier Ireland Ltd, 2020-05-01)

OBJECTIVE: Little is known about the course of echocardiographic parameters used for the evaluation of valvular heart disease (VHD) during pregnancy, hampering interpretation of possible changes (physiological vs. ...
Erratum to “Systematic review of progressive familial intrahepatic cholestasis” (Clinics and Research in Hepatology and Gastroenterology (2019) 43(1) (20–36), (S2210740118301499), (10.1016/j.clinre.2018.07.010))

Baker, Alastair; Kerkar, Nanda; Todorova, Lora; Kamath, Binita M; Houwen, Roderick H J (Elsevier Masson, 2020-02)

The publisher regrets that the running title that appeared at the top of each page was incorrect. This title should have read, “PFIC systematic review”. The publisher would like to apologise for any inconvenience caused.
A 7 Tesla fMRI investigation of human tinnitus percept in cortical and subcortical auditory areas

Berlot, Eva; Arts, Remo; Smit, Jasper; George, Erwin; Gulban, Omer Faruk; Moerel, Michelle; Stokroos, Robert; Formisano, Elia; De Martino, Federico (Elsevier, 2020)

Tinnitus is a clinical condition defined by hearing a sound in the absence of an objective source. Early experiments in animal models have suggested that tinnitus stems from an alteration of processing in the auditory ...
A comparison of international clinical practice guidelines on adult chronic rhinosinusitis shows considerable variability of recommendations for diagnosis and treatment

Kaper, N. M.; van der Heijden, G. J.M.G.; Cuijpers, S. H.; Stokroos, R. J.; Aarts, M. C.J. (Springer-Verlag, 2020-03)

Objectives: To compare international clinical practice guidelines on adult chronic rhinosinusitis (CRS). Design: Extensive literature search in Embase, PubMed and the internet (Google, websites of well-known guideline ...
Splenic Red Pulp Macrophages Cross-Prime Early Effector CTL That Provide Rapid Defense against Viral Infections

Enders, Marika; Franken, Lars; Philipp, Marie-Sophie; Kessler, Nina; Baumgart, Ann-Kathrin; Eichler, Melanie; Wiertz, Emmanuel J H; Garbi, Natalio; Kurts, Christian (American Association of Immunologists, 2020-01-01)

Cross-presentation allows dendritic cells (DCs) to present peptides derived from endocytosed Ags on MHC class I molecules, which is important for activating CTL against viral infections and tumors. Type 1 classical DCs ...
A Prospective Observational Registry Evaluating Clinical Outcomes of Radium-223 Treatment in a Non-study Population

ROTOR investigators and the Dutch Uro-Oncology Study group (DUOS15101). (John Wiley & Sons Inc., 2020-08-15)

The ALSYMPCA study established a 3.6 month Overall Survival (OS) benefit in metastatic Castration Resistant Prostate Cancer (mCRPC) patients treated with Radium-223 dichloride (Ra-223) over placebo. Here we report clinical ...
Longitudinal epigenome-wide association studies of three male military cohorts reveal multiple CpG sites associated with post-traumatic stress disorder

PGC PTSD EWAS Consortium (Springer-Verlag, 2020-01-13)

BACKGROUND: Epigenetic mechanisms have been suggested to play a role in the development of post-traumatic stress disorder (PTSD). Here, blood-derived DNA methylation data (HumanMethylation450 BeadChip) collected prior to ...
Dutch Pharmacogenetics Working Group (DPWG) guideline for the gene–drug interaction of DPYD and fluoropyrimidines

Lunenburg, Carin A.T.C.; van der Wouden, Cathelijne H.; Nijenhuis, Marga; Crommentuijn-van Rhenen, Mandy H.; de Boer-Veger, Nienke J.; Buunk, Anne Marie; Houwink, Elisa J.F.; Mulder, Hans; Rongen, Gerard A.; van Schaik, Ron H.N.; van der Weide, Jan; Wilffert, Bob; Deneer, Vera H.M.; Swen, Jesse J.; Guchelaar, Henk Jan (Springer Nature, 2020-04)

Despite advances in the field of pharmacogenetics (PGx), clinical acceptance has remained limited. The Dutch Pharmacogenetics Working Group (DPWG) aims to facilitate PGx implementation by developing evidence-based ...
Consensus recommendations for the role and competencies of the EBMT clinical pharmacist and clinical pharmacologist involved in hematopoietic stem cell transplantation

EBMT Working Group (Springer Nature, 2020-01-01)
Clinical trial simulation to optimize trial design for fludarabine dosing strategies in allogeneic hematopoietic cell transplantation

Langenhorst, Jurgen B; Dorlo, Thomas P C; van Kesteren, Charlotte; van Maarseveen, Erik M; Nierkens, Stefan; de Witte, Moniek A; Jan Boelens, Jaap; Huitema, Alwin D R (American Society for Clinical Pharmacology and Therapeutics, 2020-05)

Optimal fludarabine exposure has been associated with improved treatment outcome in allogeneic hematopoietic cell transplantation, suggesting potential benefit of individualized dosing. A randomized controlled trial (RCT) ...
Addressing heterogeneity in amyotrophic lateral sclerosis CLINICAL TRIALS

Goyal, Namita A; Berry, James D; Windebank, Anthony; Nathan, P; Maragakis, Nicholas J; van den Berg, Leonard H; Genge, Angela; Miller, Robert; Baloh, Robert H; Kern, Ralph; Gothelf, Yael; Lebovits, Chaim; Cudkowicz, Merit (John Wiley & Sons Inc., 2020-08)

Amyotrophic lateral sclerosis (ALS) is a debilitating neurodegenerative disorder with complex biology and significant clinical heterogeneity. Many preclinical and early phase ALS clinical trials have yielded promising ...
Increased assessment of HER2 in metastatic gastroesophageal cancer patients: a nationwide population-based cohort study

Dijksterhuis, Willemieke P M; Verhoeven, Rob H A; Meijer, Sybren L; Slingerland, Marije; Haj Mohammad, Nadia; de Vos-Geelen, Judith; Beerepoot, Laurens V; van Voorthuizen, Theo; Creemers, Geert-Jan; van Oijen, Martijn G H; van Laarhoven, Hanneke W M (Springer Japan, 2020-07-01)

Background: Addition of trastuzumab to first-line palliative chemotherapy in gastroesophageal cancer patients with HER2 overexpression has shown to improve survival. Real-world data on HER2 assessment and administration ...
Effectiveness of a stepwise cardiometabolic disease prevention program: Results of a randomized controlled trial in primary care

Stol, Daphne M; Badenbroek, Ilse F; Hollander, Monika; Nielen, Mark M J; Kraaijenhagen, Roderik A; Schellevis, François G; de Wit, Niek J (Academic Press Inc., 2020-03-01)

Effective preventive strategies for cardiometabolic disease (CMD) are needed. We aim to establish the effectiveness of a stepwise CMD risk assessment followed by individualized treatment if indicated compared to care as ...
Biomechanical quality assurance criteria for deformable image registration algorithms used in radiotherapy guidance

Zachiu, Cornel; de Senneville, Baudouin Denis; Raaymakers, Bas W; Ries, Mario (IOP Publishing Ltd., 2020-01-10)

Image-guided radiation therapy (IGRT) allows radiation dose deposition with a high degree of geometric accuracy. Previous studies have demonstrated that such therapies may benefit from the employment of deformable image ...

Now showing items 19861-19880 of 40729